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Cyclic AMP-Dependent Protein Kinases

More information in Books or onNLM PubMed
Definition: A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.  DF: CAMP PROTEIN KINASES   
Examples Cyclic AMP-Dependent Protein Kinase Type I; Cyclic AMP-Dependent Protein Kinase Type II 		Other names cAMP-Dependent Protein Kinases; Adenosine Cyclic Monophosphate-Dependent Protein K; Protein Kinase A; cAMP Dependent Protein Kinases; cAMP Dependent Protein Kinase; Protein Kinases, cAMP-Dependent; Protein Kinase, cAMP-Dependent; Cyclic AMP Dependent Protein Kinases; Cyclic AMP Dependent Protein Kinase; Adenosine Cyclic Monophosphate Dependent Protein K; cAMP-Dependent Protein Kinase; Cyclic AMP-Dependent Protein Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo(1,2,3-fg-3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid hexyl ester  0   *Azocines Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Neurotox Res 2011 Jul;20(1):40-50
PRKX protein, mouse  EC 2.7.11.11.-   *Cyclic AMP-Dependent Protein Kinases. Kidney Int. 2009 Jul;76(1):54-62
ARC 1034  0   *Dipeptides Adenosine/*analogs & derivatives Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. J Med Chem 2009 Jan 22;52(2):308-21
cAMP-dependent protein kinase inhibitor gamma, mouse  0   *Intracellular Signaling Peptides and Proteins Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Int J Biochem Cell Biol 2006;38(12):2064-73
PkaB protein, Aspergillus nidulans  EC 2.7.1.37   *Fungal Proteins *Cyclic AMP-Dependent Protein Kinases. Eukaryot Cell 2005 Aug;4(8):1465-76
PKIA protein, human  0   *Adaptor Proteins, Signal Transducing Cyclic AMP-Dependent Protein Kinases.
Pkia protein, rat  0   *Carrier Proteins Cyclic AMP-Dependent Protein Kinases.
A-kinase anchor protein 140, rat  0   *A Kinase Anchor Proteins Cyclic AMP-Dependent Protein Kinases. Mol Cell Endocrinol 2002 Jun 28;192(1-2):105-13
ROPN1L protein, human  0   *Adaptor Proteins, Signal Transducing Spermatozoa Cyclic AMP-Dependent Protein Kinases. Biol Reprod. 2002 Jun;66(6):1755-61
TPK2 protein, S cerevisiae  EC 2.7.1.-   *Cyclic AMP-Dependent Protein Kinases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2002 Jun;22(12):3981-93
10''-deoxybalanol  0   *Azepines *Benzophenones Protein Kinase C Cyclic AMP-Dependent Protein Kinases. Mol Pharmacol 1999 Aug;56(2):377-82
HYB 165  0   *Oligonucleotides Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Clin Cancer Res 1999 Apr;5(4):875-81
EPK2 protein, Euglena gracilis  EC 2.7.10.-   *Protozoan Proteins *Cyclic AMP-Dependent Protein Kinases.
BARKct protein, recombinant  EC 2.7.1.-   *Peptide Fragments *Recombinant Proteins *Cyclic AMP-Dependent Protein Kinases. Arterioscler Thromb Vasc Biol 1998 Aug;18(8):1275-80
AKAP7 protein, human  0   *Membrane Proteins *A Kinase Anchor Proteins Cyclic AMP-Dependent Protein Kinases. EMBO J 1998 Apr 15;17(8):2261-72; Neuron 1998 May;20(5):1017-26
Pkia protein, mouse  0   *Intracellular Signaling Peptides and Proteins Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. J Biol Chem 1997 Aug 8;272(32):20021-9
PKIG protein, human  0   *Intracellular Signaling Peptides and Proteins Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. J Biol Chem 1997 Jul 18;272(29):18169-78
PKIB protein, human  0   *Intracellular Signaling Peptides and Proteins Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Proc Natl Acad Sci U S A 1991 Jun 15;88(12):5383-7
testis-specific A-kinase-anchoring-protein, rat  0   *Carrier Proteins Spermatozoa Cyclic AMP-Dependent Protein Kinases. Eur J Biochem 1997 Jun 1;246(2):425-32
8-bromoadenosine-3',5'-cyclic monophosphorothioate  0   *Thionucleotides 8-Bromo Cyclic Adenosine Monophosphate/*analogs & derivatives Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Biochem Biophys Res Commun 1997 Mar 27;232(3):626-30
robustic acid  5307-59-5   *Isoflavones Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Phytochemistry 1997 Mar 44(5):787-96
warangalone  4449-55-2   *Isoflavones Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Phytochemistry 1997 Mar;44(5):787-96
Walsh peptide  0   *Peptides Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Neuron 1993 Dec;11(6):1023-35
3-(N-acetylamino)-5-(N-decyl-N-methylamino)benzyl alcohol  103955-90-4   *Benzyl Alcohols Cyclic AMP-Dependent Protein Kinases/agonists. Carcinogenesis 1990;11(12):2123
KT 5720  108068-98-0   *Pyrroles *Carbazoles Protein Kinase C/antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Anti-Bacterial Agents ; Enzyme Inhibitors 		J Neurochem 1988;51(5):1565
N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide  84478-11-5   *Isoquinolines Protein Kinase C/antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Biochem Biophys Res Commun 1987;145(3):1315
N-(2-guanidinoethyl)-5-isoquinolinesulfonamide  91742-10-8   *Isoquinolines *Sulfonamides Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Calcium Channel Blockers ; Protein Kinase Inhibitors 		J Pharmacol Exp Ther 1984;231(1):141
adenosine-3',5'-cyclic phosphorothioate  23645-17-2   *Thionucleotides Cyclic AMP/*analogs & derivatives Stereoisomerism Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases/agonists.
Pharma Action Protein Kinase Inhibitors 		FEBS Lett 91(2):182;1978; J Biol Chem 1980;255(2):331; J Biol Chem l979;254(20):9959
protein kinase modulator  0   *Intracellular Signaling Peptides and Proteins Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Adv Cyclic Nucleotide Res 9:199;1978; Biochem Biophys Res Commun 65(4):1214;1975; Biochem Biophys Res Commun 88(2):462;1979; Endocrinology 101(5):1621;1977; Int J Biochem 9(5):331;1978; J Biol Chem 246:1977;1971; J Biol Chem 254(4):1241;1979
ophiocordin  63590-19-2 Benzoic acid, 4-(2-(((hexahydro-4-((4-hydroxybenzoyl)oxy)-1H-azepin-3-yl)amino)carbonyl)-6-hydroxybenzoyl)-3,5-dihydroxy  *Azepines *Hydroxybenzoic Acids Protein Kinase C/antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors. Arch Microbiol 113(1/2):121;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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