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Cyclic GMP-Dependent Protein Kinases

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Definition: A group of enzymes that are dependent on cyclic GMP and catalyzes the phosphorylation of serine or threonine residues of proteins.      Other names cGMP-Dependent Protein Kinases; Guanosine Cyclic Monophosphate-Dependent Protein K; cGMP Dependent Protein Kinases; Protein Kinases, cGMP-Dependent; Guanosine Cyclic Monophosphate Dependent Protein K; Guanosine Cyclic 3',5' Phosphate Dependent Protein; Cyclic GMP Dependent Protein Kinases; Cyclic GMP Dependent Protein Kinase; Kinases, cGMP-Dependent Protein; Protein Kinase G; Guanosine Cyclic 3',5'-Phosphate-Dependent Protein; Cyclic GMP-Dependent Protein Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DT-3 peptide  0   *Peptides Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. Vascul Pharmacol 2010 Nov-Dec;53(5-6):215-22
foraging protein, Drosophila  EC 2.7.1.37   *Cyclic GMP-Dependent Protein Kinases *Drosophila Proteins. Learn Mem 2008;15(3):133-42
9-fluorenylmethoxycarbonyl-prolyl-pyrrolidine-2-nitrile  0   *Nitriles Proline/*analogs & derivatives Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. Hypertension 2004 May;43(5):1140-5
EGL-4 protein, C elegans  EC 2.7.1.37   *Cyclic GMP-Dependent Protein Kinases *Caenorhabditis elegans Proteins. Neuron 2002 Dec 19;36(6):1079-89
cGMP-dependent protein kinase II  EC 2.7.11.12   *Cyclic GMP-Dependent Protein Kinases. J Clin Invest 1998 Oct 15;102(8):1576-2
Rp-8-bromoguanosine 3',5'-cyclic monophosphorothioate  0   Cyclic GMP/*analogs & derivatives Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. J Vasc Res 1996 Sep-Oct;33(5):386-94
8-bromo-beta-phenyl-1,N(2)-ethenoguanosine 3',5'-cyclic monophosphorothioate  172806-21-2   *Thionucleotides Cyclic GMP/*analogs & derivatives Stereoisomerism Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. Br J Pharmacol 1995 Dec;116(8):3110
8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate  0   *Thionucleotides Cyclic GMP/*analogs & derivatives Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Proc Natl Acad Sci U S A 1994 Dec 6;91(25):12086-90
cGMP-dependent protein kinase I  EC 2.7.11.12   *Cyclic GMP-Dependent Protein Kinases. Eur J Biochem 1994 Apr 1;221(1):581-93
KT 5823  126643-37-6 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester, (9R-(9alpha,10beta,12alpha))  *Carbazoles Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Protein Kinase Inhibitors 		Res Commun Chem Pathol Pharmacol 1991 Oct;74(1):3-14
8-bromocyclic GMP  31356-94-2 8-bromoguanosine, cyclic 3',5'-(hydrogen phosphate)  Cyclic GMP/*analogs & derivatives Cyclic GMP-Dependent Protein Kinases/antagonists & inhibitors. Brain Res 166(1):113;1979; Endocrine Res Commun 4(6):329;1978; Exp Eye Res 27(4):387;1978; J Biol Chem 1980;255(4):1235; J Biol Chem 254(12):5321;1979; J Biol Chem 254(17):8554;1979; J Mol Cel Cardiol 10(6):573;1978; JPn J Pharmacol 1979;29(3):423; Klin Wochenschr 56(Suppl 1):51;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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