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Immediate-Early Proteins

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Definition: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.  proteins coded by immed-early genes: read MeSH definition for history of "immediate-early"   
Examples Adenovirus E1 Proteins; Butyrate Response Factor 1; Early Growth Response Transcription Factors; Tristetraprolin 		Other names Proteins, Immediate-Early; Proteins, Immediate Early; Immediate Early Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
UL54 protein, herpes simplex virus type II  0   *Viral Proteins *Immediate-Early Proteins. Int J Dermatol. 2011 Mar;50(3):362-6
BICP0 protein, Bovine herpesvirus 5  0   *Viral Proteins *Immediate-Early Proteins. Vet Microbiol. 2010 Jun 16;143(1):37-44
ETR101 protein, human  0   *Trans-Activators *Immediate-Early Proteins. Biosci Biotechnol Biochem 2009 Jul;73(7):1653-60
Nr4a1 protein, rat  0   *Nuclear Receptor Subfamily 4, Group A, Member 1 Immediate-Early Proteins.
Ier2 protein, zebrafish  0   *Immediate-Early Proteins *Zebrafish Proteins. Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2230-5
IE2 protein, human herpesvirus 6A  0   *Immediate-Early Proteins. J Neuroimmune Pharmacol 2008 Jun;3(2):105-16
US1 protein, human herpesvirus 2  0   *Immediate-Early Proteins. J Clin Microbiol 2008 Feb;46(2):780-4
U95 protein, human herpesvirus 6B  0   *Immediate-Early Proteins. J Virol 2008 Jan;82(2):1011-20
BTG2 protein, rat  0   *Immediate-Early Proteins *Tumor Suppressor Proteins Cell Cycle Proteins. Proc Natl Acad Sci U S A 1991 Apr 15;88(8):3353-7
IEX-1 protein, mouse  0   *Immediate-Early Proteins. Birth Defects Res A Clin Mol Teratol 2005 Apr;73(4):5468-77
MI-ER1 protein, mouse  0   *Immediate-Early Proteins. DNA Seq 2005 Jun;16(3):237-40
Sgk2 protein, mouse  EC 2.7.1.37   *Protein-Serine-Threonine Kinases *Immediate-Early Proteins. J Neurosci 2005 Feb 23;25(8):1935-42
Ifrd2 protein, rat  0   *Membrane Proteins *Immediate-Early Proteins.
ORF45 protein, murine gammaherpesvirus 68  0   *Immediate-Early Proteins. J Virol 2005 Apr;79(8):5129-41
Rhpn2 protein, mouse  0   *Immediate-Early Proteins *Adaptor Proteins, Signal Transducing. Mol Cell Biol 2005 Apr;25(7):2846-52
Rnf39 protein, mouse  0   *Immediate-Early Proteins Zinc Fingers.
Rnf39 protein, rat  0   *Immediate-Early Proteins Zinc Fingers.
Ras-like protein, mouse  0   *Repressor Proteins *Immediate-Early Proteins. Biochem J 2004 Oct 1;383(Pt 1):187-99
nephroblastoma overexpressed protein, rat  0   *Immediate-Early Proteins *Intercellular Signaling Peptides and Proteins. Biochem Pharmacol. 2004 Oct 1;68(7):1391-400
Ptp4a1 protein, rat  EC 3.1.3.48   *Protein Tyrosine Phosphatases *Immediate-Early Proteins.
IFRD1 protein, human  0   *Immediate-Early Proteins Genes, Tumor Suppressor.
Ifrd1 protein, mouse  0   *Membrane Proteins *Immediate-Early Proteins Genes, Tumor Suppressor.
Ifrd2 protein, mouse  0   *Membrane Proteins *Immediate-Early Proteins.
Btg2 protein, mouse  0   *Immediate-Early Proteins *Tumor Suppressor Proteins Cell Cycle Proteins.
verge protein, rat  0   *Immediate-Early Proteins. J Neurosci 2004 Apr 21;24(16):4092-103
Ier5 protein, rat  0   *Nuclear Proteins *Immediate-Early Proteins.
Ier5 protein, mouse  0   *Nuclear Proteins *Immediate-Early Proteins.
Laptm5 protein, mouse  0   *Membrane Proteins *Immediate-Early Proteins.
IE1-pp65 recombinant protein, Human cytomegalovirus  0   *Phosphoproteins *Viral Matrix Proteins *Immediate-Early Proteins Recombinant Proteins. Cytotherapy 2002;4(1):11-9
peptide IE1 (354-363)  0   *Peptide Fragments *Immediate-Early Proteins Cytomegalovirus. Virology 2002 Apr 10;295(2):208-16
immediate-early 1 protein, human herpesvirus 6  0   *Phosphoproteins *Immediate-Early Proteins. J Biol Chem 2002 May 31;277(22):19679-87
ORF45 protein, Kaposi's sarcoma-associated herpesvirus  0   *Immediate-Early Proteins. J Virol 1999 Jul;73(7):5556-67
IE19 protein, human cytomegalovirus  0   *Immediate-Early Proteins. J Virol 2002 Apr;76(7):3158-67
ie0 protein, baculovirus  0   *Trans-Activators *Immediate-Early Proteins. Virology 2001 Nov 25;290(2):211-23
RNF39 protein, human  0   *Immediate-Early Proteins Zinc Fingers. Biochem Biophys Res Commun 2001 Nov 30;289(2):479-84
Dub2a protein, mouse  EC 3.4.-   *Endopeptidases *Immediate-Early Proteins Blood Proteins. Blood 2001 Aug 1;98(3):636-42
UL37 protein, Human herpesvirus 5  0   *Immediate-Early Proteins. Virology. 2001 Jan 5;279(1):233-40
Rta protein, Human herpesvirus 8  0   *Trans-Activators *Immediate-Early Proteins Herpesvirus 8, Human. J Gen Virol. 2000 Dec;81 Pt 120:3043-8
K5 protein, Human herpesvirus 8  0   *Immediate-Early Proteins Zinc Fingers. J Virol 2000 Mar;74(6):2867-75
gene 50 protein, gammaherpesvirus 68  0   *Trans-Activators *Immediate-Early Proteins Viral Proteins. J Virol 2000 Feb;74(4):2029-37
IER5 protein, human  0   *Nuclear Proteins *Immediate-Early Proteins. Genomics 1999 Feb 1;55(3):327-34
ORF 50 transactivator  0   *Trans-Activators Immediate-Early Proteins. Virology 1998 Dec 20;252(2):301-12
milk protein, Xenopus  0   *Immediate-Early Proteins *Homeodomain Proteins *Xenopus Proteins. Development 1998 Jul;125(14):2577-85
Ptp4a3 protein, mouse  0   *Protein Tyrosine Phosphatases *Immediate-Early Proteins. Biochem Biophys Res Commun 1998 Mar 17;244(2):421-7
Ptp4a2 protein, mouse  0   *Protein Tyrosine Phosphatases *Immediate-Early Proteins. Biochem Biophys Res Commun 1998 Mar 17;244(2):421-7
Ac-PNK-PNL protein, Autographa californica nucleopolyhedrovirus  0   *Immediate-Early Proteins. J Gen Virol 1998 Mar;79(Pt 3):629-37
IU12 protein, Xenopus  0   *Membrane Proteins *Immediate-Early Proteins. Cell Res 1997 Dec;7(2):179-93
ER1 protein, Xenopus  0   *Nuclear Proteins *Immediate-Early Proteins *Xenopus Proteins Trans-Activators. J Biol Chem 1997 Oct 10;272(41):25591-5
Scfd1 protein, rat  0   *Immediate-Early Proteins *Munc18 Proteins. J Biol Chem 1997 Jun 27;272(26):16438-44
ICP47 protein, Herpes simplex virus  0   *Immediate-Early Proteins. J Exp Med 1997 May 5;185(9):1565-72
Homer protein  0   *Carrier Proteins Transcription Factors Immediate-Early Proteins. Nature 1997 Mar 20;286(6622):284-8
Dub2 protein, mouse  EC 3.4.-   *Endopeptidases *Immediate-Early Proteins. J Biol Chem 1997 Jan 3;272(1):51-7
IE03 protein, herpes simplex virus 6  0   *Immediate-Early Proteins Antigens, Viral. Virus Res 1996 Apr;41(2):193-200
SQSTM1 protein, human  0   *Adaptor Proteins, Signal Transducing Carrier Proteins Immediate-Early Proteins. Am J Hum Genet 2002 Jun;70(6):1582-8; Proc Natl Acad Sci U S A 1996 Jun 11;93(12):5991-5
Dub1 protein, mouse  EC 3.4.-   *Endopeptidases *Immediate-Early Proteins. Proc Natl Acad Sci U S A 1996 Apr 16;93(8):3275-9
BICP27 protein, Bovine herpesvirus 1  0   *Phosphoproteins *Immediate-Early Proteins. J Gen Virol 1996 Apr;77( Pt 4):615-25
US3 protein, cytomegalovirus  0   *Glycoproteins *Membrane Proteins *Immediate-Early Proteins Trans-Activators. J Virol 1995 Sep;69(9):5362-7
UL98 protein, cytomegalovirus  0   *Immediate-Early Proteins. J Virology 1995 Sep;69(9):5304-10
Ac-PE38 protein, Autographa californica nucleopolyhedrovirus  0   *Trans-Activators *Immediate-Early Proteins DNA-Binding Proteins Zinc Fingers. J Virol 1995 Sep;69(9):5287-93
IE-1 protein, murine cytomegalovirus  0   *Trans-Activators *Immediate-Early Proteins. J Infect Dis 1995 Aug;172(2):371-9
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