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Receptors, Calcitonin Gene-Related Peptide

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Definition: Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.      Other names Receptors, CGRP; Calcitonin Gene-Related Peptide Receptors; CGRP Receptors; Receptors, Calcitonin Gene Related Peptide; Calcitonin Gene Related Peptide Receptors; Calcitonin Gene Related Peptide Receptor; Calcitonin-Gene Related Peptide Receptor; CGRP Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MK 2918  0   *Azepines *Imidazoles Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. Bioorg Med Chem Lett 2011 May 1;21(9):2683-6
2-(8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro(4.5)dec-9-yl)-N-(2'-oxo-1,1',2',3-tetrahydrospiro(indene-2,3'-pyrrolo(2,3-b)pyridin)-5-yl)acetamide  0   *Spiro Compounds *Bicyclo Compounds, Heterocyclic Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Apr;333(1):152-60
4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide  0   *Indazoles *Quinazolinones Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. J Med Chem 2008 Aug 28;51(16):4858-61
N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide  0   *Azepines *Imidazoles Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. J Med Chem 2007 Nov 15;50(23):5564-7
alpha-calcitonin gene-related peptide, ethylamide-Cys(2,7)  0   Calcitonin Gene-Related Peptide/*analogs & derivatives Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. Life Sci 2006 Jun 13;79(3):265-71
1-(N(2)-(3,4-dibromo-N-((4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl)carbonyl)tyrosyl)lysyl)-4-(4-pyridinyl)piperazine  0   *Dipeptides *Quinazolines Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. Proc Natl Acad Sci U S A 2005 Sep 20;102(38):5921-31
olcegepant  0   *Dipeptides *Quinazolines Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. Curr Opin Investig Drugs 2004 Jul;5(7):731-5
Crcp protein, mouse  0   *Receptors, Calcitonin Gene-Related Peptide.
Crcp protein, rat  0   *Receptors, Calcitonin Gene-Related Peptide.
4-(2-oxo-2,3-dihydrobenzimidazol-1-yl)piperidine-1-carboxylic acid (1-(3,5-dibromo-4-hydroxybenzyl)-2-oxo-2-(4-phenylpiperazin-1-yl)ethyl)amide  0   *Piperazines *Piperidines Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors. Eur J Pharmacol 2001 Mar 9;415(1):39-44
calcitonin gene-related peptide, (acetylmethoxy)cysteinyl(2,7)  0   Calcitonin Gene-Related Peptide/*analogs & derivatives Receptors, Calcitonin Gene-Related Peptide/agonists. Eur J Pharmacol 1999 Dec 3;385(2-3):147-54
RCP9 protein, human  0   *Receptors, Calcitonin Gene-Related Peptide. Proc Natl Acad Sci U S A 1996 Apr 16;93(8):3455-60
calcitonin gene-related peptide (8-37)  119911-68-1   *Peptide Fragments *Calcitonin Gene-Related Peptide Receptors, Calcitonin Gene-Related Peptide/antagonists & inhibitors.
Pharma Action Miotics 		Am J Physiol 1989;256(2 Pt 1):E331

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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