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Receptors, Corticotropin-Releasing Hormone

More information in Books or onNLM PubMed
Definition: Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.  DF: note short X ref    Other names Receptors, CRH; Corticotropin Releasing-Hormone Receptors; CRH Receptors; Releasing-Hormone Receptors, Corticotropin; Releasing-Hormone Receptor, Corticotropin; Releasing-Factor Receptors, Corticotropin; Receptors, Corticotropin Releasing-Hormone; Receptors, Corticotropin Releasing-Factor; Receptors, Corticotropin Releasing Hormone; Receptor, Corticotropin Releasing-Hormone; Receptor, CRH; Receptor, CRF; Hormone Receptors, Corticotropin-Releasing; Corticotropin-Releasing Hormone Receptors; Corticotropin Releasing Hormone Receptors; Corticotropin Releasing Hormone Receptor; Corticotropin Releasing Factor Receptors; Receptors, CRF; Corticotropin Releasing-Hormone Receptor; Corticotropin Releasing-Factor Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NBI 77860  0   *Oxadiazoles *Azabicyclo Compounds Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. Bioorg Med Chem Lett 2010 Dec 15;20(24):7259-64
4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile  0   *Pyrazines *Pyridines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2009 Dec 10;52(23):7653-68
(3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridin-4-yl)(1-ethylpropyl)amine  0   *Aminopyridines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1385-92
4-(1-ethylpropoxy)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)pyridine  0   *Pyridines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1377-84
astressin-2B  0   *Peptide Fragments *Peptides, Cyclic Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Neurosci 2008 Apr 9;28(15):3861-76
cyclo(31-34)(phenylalanyl(12)-norleucyl(21,28)-glutamyl(31)-lysyl(34))acetyl-corticotropin releasing factor (4-41)  0   *Peptides, Cyclic Corticotropin-Releasing Hormone/*analogs & derivatives Receptors, Corticotropin-Releasing Hormone/agonists. J Med Chem 2007 Apr 5;50(7):1668-74
2-(2,4-dichlorophenyl)-4-methyl-6-(1-propylbutyl)-2,6,7,8-tetrahydro-1,2,3,6-tetraazaacenaphthylene  0   *Acenaphthenes Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2005 Jun 16;48(12):4100-10
1-(2-chloro-4-methylphenyl)-7-methyl-5-(1-propylbutyl)-1,3,4,5-tetrahydro-1,5,8-triazaacenaphthylene  0   *Acenaphthenes Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2005 Jun 16;48(12):4100-10
corticotropin-releasing factor receptor type 2a, rat  0   *Receptors, Corticotropin-Releasing Hormone. Protein Sci 2004 Sep;13(9):2470-5
1-methyl-3-(N-(4-fluorophenylpentyl)-N-propyl)amino-5-(2-methoxy-4-dichlorophenyl)-1H-(1,2,4)triazole  0   *Triazoles Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2005 Mar 10;48(5):1540-9
8-(butylethylamino)-4-(2,6-dimethoxypyridin-3-yl)-6-methyl-3,4-dihydro-1H-pyrido(2,3-b)pyrazin-2-one  0   *Pyrazines *Pyridines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2004 Nov 4;47(23):5783-90
(N-(2-chloro-4,6-dimethylphenyl)-1-(1-methoxymethyl)-(2-methoxymethyl)-6-methyl-1H-1,2,3-triazolo(4,5-c)pyridin-4-amine) mesylate  0   *Pyridines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. Neuropsychopharmacology 2001 Oct;25(4):585-600
CRF receptor type 3  0   *Receptors, Corticotropin-Releasing Hormone. Endocrinology 2001 Jan;142(1):446-54
R 121919  0   *Pyrimidines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Psychiatr Res 2000 May-Jun;34(3):171-81
DMP 696  0   *Pyrazoles *Triazines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2000 Feb 10;43(3):449-56
oxo-7H-benzo(e)perimidine-4-carboxylic acid  0   *Carboxylic Acids *Quinazolines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Mar 8;9(5):765-70
CRA 1001  0   *Pyridines *Pyrimidines Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. J Pharmacol Exp Ther 1999 May;289(2):926-35
antisauvagine 30  0   *Peptide Fragments Receptors, Corticotropin-Releasing Hormone. Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15264-9
antalarmin  0   *Pyrimidines *Pyrroles Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. Endocrinology 1996 Dec;137(12):5747-50
CP 154526  0   *Pyrimidines *Pyrroles Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors. Proc Natl Acad Sci U S A 1996 Sep 17;93(19):10477-82
CRF receptor type 2  0   *Receptors, Corticotropin-Releasing Hormone. Peptides 1996;17(3):435-41
CRF receptor type 1  0   *Receptors, Corticotropin-Releasing Hormone. Peptides 1996;17(3):435-41
CRF(2alpha) receptor  0   *Receptors, Corticotropin-Releasing Hormone. Mol Pharmacol 1996 Sep;50(3):679-86
sauvagine  74434-59-6 Sauvagin  *Amphibian Proteins *Peptide Hormones Diuresis/drug effects Receptors, Corticotropin-Releasing Hormone/agonists. Pharmacol Res Commun 1980;12(3):185

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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