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Receptors, Glucagon

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Definition: Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.  DF: RECEPT GLUCAGON   
See Also Glucagon 		Other names Glucagon Receptors; Receptor, Glucagon; Glucagon Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LY 2189265  0   *Immunoglobulin Fc Fragments *Recombinant Fusion Proteins Glucagon-Like Peptides Receptors, Glucagon. Diabetes Metab Res Rev. 2010 May;26(4):287-96
AKHR protein, Drosophila  0   *Receptors, Glucagon *Drosophila Proteins. J Exp Biol 2008 Oct;211(Pt 19):3103-10
3-(tert-butylamino)-6,7-dichloro-2-(methylsulfonyl)quinoxaline  0   *Quinoxalines *Sulfones Receptors, Glucagon/agonists. Proc Natl Acad Sci U S A 2007 Jan 16;104(3):937-42
2-(2'-methyl)thiadiazolylsulfanyl-3-trifluoromethyl-6,7-dichloroquinoxaline  0   *Quinoxalines *Thiadiazoles Receptors, Glucagon/agonists. Proc Natl Acad Sci U S A 2007 Jan 16;104(3):937-42
GLP-2 receptor  0   *Receptors, Glucagon Glucagon-Like Peptides Glucagon-Like Peptide 1.
(1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene)hydrazide  0   *Hydrazines *Indoles Receptors, Glucagon/antagonists & inhibitors. J Med Chem 2002 Dec 19;45(26):5755-75
Bay 27-9955  0   *Biphenyl Compounds Receptors, Glucagon/antagonists & inhibitors. Diabetologiia 2001 Nov;44(11):2018-24
3-chloro-4-hydroxy-N'-((4-hydroxy-1-naphthyl)methylidene)benzohydrazide  0   *Benzamides *Hydrazones Receptors, Glucagon/antagonists & inhibitors. J Med Chem 2001 Sep 13;44(19):3141-9
L 168049  0   *Pyridines *Pyrroles Receptors, Glucagon/antagonists & inhibitors. J Biol Chem 1999 Mar 26;274(13):8694-7
2-(benzimidazo-2-ylthio)-1-(3,4-dihydroxyphenyl)-1-ethanone  0   *Benzimidazoles Receptors, Glucagon/antagonists & inhibitors. J Med Chem 1998 Dec 17;41(26):5150-7
glucagon-like peptide receptor  0   *Receptors, Glucagon Glucagon-Like Peptides Glucagon-Like Peptide 1. Endocrinology 1987;121(3):1076

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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