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Receptors, Neurokinin-2

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Definition: A class of cell surface receptors for tachykinins that prefers neurokinin A; (NKA, substance K, neurokinin alpha, neuromedin L), neuropeptide K; (NPK); or neuropeptide gamma over other tachykinins. Neurokinin-2 (NK-2) receptors have been cloned and are similar to other G-protein coupled receptors.  tachykinin receptors; DF: RECEPT NEUROKININ 2    Other names Substance K Receptors; Receptors, Substance K; Receptors, NK-2; Neurokinin-2 Receptors; Neurokinin A Receptors; SP-K Receptors; NK-2 Receptors; SP K Receptors; SP K Receptor; Receptors, SP-K; Receptors, Neurokinin A; Receptors, Neurokinin 2; Receptors, NK 2; Receptor, Substance K; Receptor, SP-K; Receptor, Neurokinin-2; Receptor, NK-2; Receptor Site, NK-2; Neurokinin 2 Receptors; Neurokinin 2 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AZD 2738  0   *Azetidines *Benzamides Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. Drug Dev Ind Pharm 2011 Jun;37(6):719-26
AZD 8081  0   *Azetidines *Benzamides Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. Drug Dev Ind Pharm 2011 Jun;37(6):702-13
ibodutant  0   *Dipeptides *Thiophenes Receptors, Neurokinin-2/antagonists & inhibitors. Neurogastroenterol Motil 2011 Jan;23(1):96-102,e10
6-methylbenzo(b)thiophene-2-carboxylic acid (1-(1-benzyl-4-(4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl)butylcarbamoyl)cyclopentyl)amide  0   *Amides *Thiophenes Receptors, Neurokinin-2/antagonists & inhibitors. J Med Chem 2010 May 27;53(10):4148-65
ZD 7944  0   *Piperidines *Sulfoxides Receptors, Neurokinin-2/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Oct 22;11(20):2769-73
SB 414240  0   *Piperidines *Quinolines Receptors, Neurokinin-2/antagonists & inhibitors Receptors, Neurokinin-3/antagonists & inhibitors. J Med Chem 2001 May 24;44(11):1675-89
SB 400238  0   *Morpholines *Quinolines Receptors, Neurokinin-2/antagonists & inhibitors Receptors, Neurokinin-3/antagonists & inhibitors. J Med Chem 2001 May 24;44(11):1675-89
SCH 378167  0   *Depsipeptides Receptors, Neurokinin-2/antagonists & inhibitors. J Antibiot (Tokyo) 2001 Feb;54(2):125-35
SCH 378199  0   *Depsipeptides Receptors, Neurokinin-2/antagonists & inhibitors. J Antibiot (Tokyo) 2001 Feb;54(2):125-35
SCH 217048  0   *Depsipeptides Receptors, Neurokinin-2/antagonists & inhibitors. J Antibiot (Tokyo) 2001 Feb;54(2):125-35
SCH 378161  0   *Depsipeptides Receptors, Neurokinin-2/antagonists & inhibitors. J Antibiot (Tokyo) 2001 Feb;54(2):125-35
4-(1-(2-(1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxo-3-piperidyl)ethyl)azetidin-3-yl)-1-piperazine sulfamide  0   *Azetidines *Piperazines Receptors, Neurokinin-2/antagonists & inhibitors. Xenobiotica 2000 Jun;30(6):627-42
MDL 103392  0   *Pyrroles *Pyrrolidines Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. Bioorg Med Chem 1999 Dec;7(12):2867-76
neuronorm, delta-Ala(1)  0   *Peptides, Cyclic Receptors, Neurokinin-2/antagonists & inhibitors. Bioorg Med Chem Lett 1998 May 19;8(10):1153-6
YM 35375  0   *Piperidines *Spiro Compounds Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1998 Feb;46(2):242-54
SR 144190  0   *Methylurea Compounds *Morpholines Receptors, Neurokinin-2/antagonists & inhibitors. Neuropeptides 1997 Oct;31(5):449-58
neurokinin A (4-10), Ala(5)  0   *Peptide Fragments Neurokinin A/*analogs & derivatives Receptors, Neurokinin-2/agonists. Neuropeptides 1997 Oct;31(5):399-402
MDL 105212A  0   *Piperidines *Pyrrolidines Stereoisomerism Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. J Pharmacol Exp Ther 1996 May;277(2):840
S 16474  0   *Oligopeptides Receptors, Neurokinin-1/antagonists & inhibitors Receptors, Neurokinin-2/antagonists & inhibitors. Eur J Pharmacol 1995 Dec 29;294(2-3):677-84
ZM 253270  0   *Pyrimidines *Pyrroles Receptors, Neurokinin-2/antagonists & inhibitors. J Pharmacol Exp Ther 1995 Sep;274(3):1216-21
3-benzyl-8-(2-(5-fluoro-1H-indol-3-yl)ethyl)-1-oxa-3,8-diazaspiro(4.5)decan-2-one  0   *Indoles *Spiro Compounds Receptors, Neurokinin-2/antagonists & inhibitors. J Med Chem 1995 Sep 15;38(19):3772-9
SR 48968  142001-63-6   *Benzamides *Piperidines Antidepressive Agents Receptors, Neurokinin-2/antagonists & inhibitors. Life Sci 1992;50(15):PL-101-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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