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Receptors, Oxytocin

More information in Books or onNLM PubMed
Definition: Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.  DF: RECEPT OXYTOCIN    Other names Oxytocin Receptors; Receptor, Oxytocin; Oxytocin Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
OXTR protein, human  0   *Receptors, Oxytocin. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19937-42
4-(3,5-dihydroxybenzyl)-N-(2-methyl-4-((1-methyl-4,10-dihydropyrazolo(3,4-b)(1,5)benzodiazepin-5(1H)-yl)carbonyl)benzyl)piperazine-1-carboxamide  0   *Benzodiazepines *Pyrazoles Receptors, Oxytocin/agonists. Neuropharmacology 2010 Jan;58(1):69-77
barusiban  0   *Oligopeptides Receptors, Oxytocin/antagonists & inhibitors. Biol Reprod 2006 Nov;75(5):809-14
3-(4-((4-chloro(2-oxo-2-(2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino)ethyl)anilino)sulfonyl)phenyl)-N-(3-(dimethylamino)propyl)propanamide  0   *Hydrazines *Sulfonamides Receptors, Oxytocin/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7882-905
N-(2-hydroxy-2-phenylethyl)-4-(methoxyimino)-1-((2'-methyl(1,1'-biphenyl)-4-yl)carbonyl)-2-pyrrolidinecarboxamide  0   *Imines *Pyrrolidines Receptors, Oxytocin/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Jul;306(1):253-61
L 372662  0   *Oxazines *Pyridines Receptors, Oxytocin/antagonists & inhibitors. J Med Chem 1998 Jun 4;41(12):2146-63
penicilide  0   *Lactones Receptors, Oxytocin/antagonists & inhibitors. J Recept Signal Transduct Res 1995 Jan-Mar;15(1-4):703-13

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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