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Receptors, Purinergic P1

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Definition: A class of cell surface receptors that prefer ADENOSINE to other endogenous PURINES. Purinergic P1 receptors are widespread in the body including the cardiovascular, respiratory, immune, and nervous systems. There are at least two pharmacologically distinguishable types (A1 and A2, or Ri and Ra).  general or unspecified; prefer specifics   
Examples Receptor, Adenosine A1; Receptors, Adenosine A2; Receptor, Adenosine A3 		Other names Receptor, Adenosine; Purinoceptors, P1; Purinoceptor, P1; Purinergic P1 Receptor; Receptors, Adenosine; Purinergic P1 Receptors; P1 Purinoceptors; Adenosine Receptors; P1 Receptors, Purinergic; P1 Receptor, Purinergic; Receptor, Purinergic P1; P1 Purinoceptor; Adenosine Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N(6)-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. J Med Chem 2003 Apr 10;46(8):1492-503
(2-amino-4,5,6,7-tetrahydrobenzo(b)thiophen-3-yl)(4-iodonaphthalen-1-yl)methanone  0   *Naphthalenes *Thiophenes Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2003 Feb 27;46(5):794-809
(2-amino-4,5,6,7-tetrahydrobenzo(b)thiophen-3-yl)(4-chloronaphthalen-1-yl)methanone  0   *Naphthalenes *Thiophenes Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2003 Feb 27;46(5):794-809
8-cyclopenta-3-(3-fluoropropyl)-1-propylxanthine  0   *Xanthines Fluorine Radioisotopes Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2002 Nov 7;45(23):5150-6
1-((7-methyl-2-phenylimidazo(1,2-a)(1,3,5)triazin-4-yl)amino)acetone  0   *Imidazoles *Triazines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2002 Nov 7;45(23):5030-6
5-(((4-pyridyl)amino)carbonyl)amino-8-methyl-2-(2-furyl)pyrazolo(4,3-e)1,2,4-triazolo(1,5-c)pyrimdiine  0   *Pyrimidines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2002 Aug 15;45(17):3579-82
1-benzyl-3-propyl-1H,3H-pyrido(2,1-f)purine-2,4-dione  0   *Purinones Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2002 Aug 1;45(16):3337-44
4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo(3,4-b)pyridine-5-carboxylic acid ethyl ester  0   *Pyrazoles *Pyridines Receptors, Purinergic P1. Bioorg Med Chem Lett 2001 Sep 17;11(18):2529-31
KMCP 98  0   *Xanthines Receptors, Purinergic P1/agonists. Gen Pharmacol 2000 Jul;35(1):47-57
VUF 5455  0   *Benzamides *Indoles Receptors, Purinergic P1/agonists. Mol Pharmacol 2001 Nov;60(5):1057-63
5'-O-ethyl-N-(3-iodobenzyl)adenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. J Med Chem 2001 Aug 30;44(18):2966-75
N-(3-iodobenzyl)-5'-O-methyladenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. J Med Chem 2001 Aug 30;44(18):2966-75
5-(((4-fluorosulfonylphenyl)amino)carbonyl)amino-8-n-propyl-2-(2-furyl)pyrazolol(4,3-e)1,2,4-triazolo(1,5-c)pyrimidine  0   *Heterocyclic Compounds, 3-Ring *Phenylurea Compounds Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2001 Aug 16;44(17):2735-42
VUF 5472  0   *Cyclohexylamines *Thiadiazoles Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2001 Mar 1;44(5):749-62
8-cyclopentyl-3-(3-(4-fluorosulfonylbenzamido)propyl)-1-propylxanthine  0   *Xanthines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2000 Dec 28;43(26):4973-80
2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate  0   *Pyridines Receptors, Purinergic P1/antagonists & inhibitors. J Membr Biol 2000 Nov 15;178(2):108-13
CVT 2759  0   *Purines Receptors, Purinergic P1/agonists. Am J Physiol Heart Circ Physiol 2001 Jan;280(1):H334-43
MRS 1741  0   Adenosine/*analogs & derivatives Thiourea/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors. J Biol Chem 2000 Sep 29;275(39):30272-9
MRS 1740  0   Adenosine/*analogs & derivatives Thiourea/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors. J Biol Chem 2000 Sep 29;275(39):30272-9
N(6)-benzyl-5'-N-ethylcarboxamidoadenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Eur J Pharmacol 2000 Apr 21;395(1):47-50
MRS 1595  0   *Xanthines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2000 Mar 23;43(6):1165-72
MRS 1204  0   *Xanthines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 2000 Mar 23;43(6):1165-72
MRE 3008-F20  0   *Phenylurea Compounds *Triazoles Receptors, Purinergic P1/antagonists & inhibitors. Bioorg Med Chem Lett 2000 Feb 7;10(3):209-11
2-((1-phenylpropyl)amino)adenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Nucleosides Nucleotides 1999 Oct;18(10):2175-91
2-((phenylisopropyl)amino)adenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Nucleosides Nucleotides 1999 Oct;18(10):2175-91
2,4-diethyl-1-methyl-3-(ethylsulfanylcarbonyl)-5-ethyloxycarbonyl-6-phenylpyridinium  0   *Pyridinium Compounds Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1999 Oct 7;42(20):4232-8
N-(3-tetrahydrofuranyl)-6-aminopurine riboside  0   *Furans Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Br J Pharmacol 1999 Jan;126(1):137-46
4-amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo(4,3-a)-quinoxalin-1-one  0   *Quinoxalines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors. Arch Pharm (Weinheim) 1999 Feb;332(2):39-41
propyl 1-ethyl-8-oxo-3-phenyl-5,6,7,8-tetrahydro-7-thiaisoquinoline-4-carboxylate  0   *Bicyclo Compounds, Heterocyclic Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1999 Feb 25;42(4):706-21
XH-14  0   *Benzofurans Guaiacol/*analogs & derivatives Receptors, Purinergic P1. Bioorg Med Chem 1998 Sep;6(9):1517-24
8-butylamino-N(6)-cyclopentyladenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Biochem Pharmacol 1998 Dec 1;56(11):1437-45
VUF 8504  0   *Isoquinolines *Pyridines Ligands Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):3994-4000
N-(3-(2-pyridinyl)isoquinolin-1-yl)benzamidine  0   *Benzamidines *Isoquinolines Ligands Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):3987-93
FSPTP pyrimidine  0   *Pyrimidines *Triazoles Receptors, Purinergic P1/antagonists & inhibitors. Circulation 1998 Aug 18;98(7):711-8
MSX 2 compound  0   *Xanthines Receptors, Purinergic P1/antagonists & inhibitors. Neuroreport 1998 Jun 1;9(8):1803-6
2-(3-hydroxy-3-phenyl-1-propyn-1-yl)-5'-N-ethylcarboxamidoadenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Bioorg Med Chem 1997 Dec;5(12):2267-75
3,6-dichloro-2'-isopropyloxy-4'-methylflavone  0   *Flavonoids Receptors, Purinergic P1/antagonists & inhibitors. Neuropharmacology 1997 Sep;36(9):1157-65
N(6)-(4-sulfophenyl)adenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Br J Pharmacol 1997 Oct;122(3):525-33
N6-(4-(((4-((((2-((((isothiocyanatophenyl)amino)thiocarbonyl)amino)ethyl)amino)carbonyl)methyl)anilino)carbonyl)methyl)phenyl)adenosine  0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Mol Pharmacol 1997 Sep;52(3):491-8
8-dipropyl-8-cyclopentylxanthine  0   *Xanthines Receptors, Purinergic P1/antagonists & inhibitors. Pharmacol 1997 Jun;80(6):295-300
8-cyclohexylcaffeine  0   Caffeine/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors. Pharmacol Toxicol 1997 Jun;80(6):295-300
KF 17387  0   *Xanthines Receptors, Purinergic P1/antagonists & inhibitors. Eur J Pharmacol 1996 Oct 17;313(3):237-42
8-butylaminoadenosine  65456-84-0   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. J Pharmacol Exp Ther 1996 Dec;279(3):1439-46
2-(cyclohexylmethylidenehydrazino)adenosine  144348-08-3   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Circulation 1996 Oct 1;94(7):1726-32
alpha-((4-(methylamino)-1-phenylpyrazolo(3,4-d)pyrimidin-6-yl)thio)hexanamide  0   *Pyrazoles *Pyrimidines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1996 Oct 11;39(21):4156-61
alpha-((4-amino-1-phenylpyrazolo(3,4-d)pyrimidin-6-yl)thio)hexanamide  0   *Pyrazoles *Pyrimidines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1996 Oct 11;39(21):4156-61
MRS 1097  0   *Dihydropyridines Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1996 Jul 19;39(15):2980-9
2-(2-phenylethoxy)adenosine  131865-79-7   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Naunyn Schmiedebergs Arch Pharmacol 1996 Feb;353(3):250-60
2-hexyloxyadenosine  50257-95-9   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Naunyn Schmiedebergs Arch Pharmacol 1996 Feb;353(3):250-60
WRC 0571  0   *Norbornanes Adenine/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors. J Pharmacol Exp Ther 1996 Feb;276(2):490
RS 74513-000  0   *Thiophenes Receptors, Purinergic P1/agonists. Naunyn Schmiedebergs Arch Pharmacol 1995 Aug;352(2):206-12
uniblue A  34293-80-6   *Anthraquinones *Sulfonic Acids Receptors, Purinergic P1/antagonists & inhibitors Receptors, Purinergic P2/antagonists & inhibitors. Br J Pharmacol 1995 Jun;115(3):427-32
2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide  163042-96-4   Adenosine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors Receptors, Purinergic P1/agonists. J Med Chem 1994 Oct 14;37(21):3614-21
N-((1S,trans)-2-hydroxycyclopentyl)adenosine  124555-18-6 Adenosine, N-(2-hydroxycyclopentyl)-, (1S-trans)  Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists.
Pharma Action Hypolipidemic Agents 		Clin Sci (Colch) 1993 Jun;84(6):663-9
KFM 19  133058-72-7   *Xanthines Receptors, Purinergic P1/antagonists & inhibitors. Neurosci Lett 1993 Feb 19;150(2):191-4
KF 20274  143394-68-7   *Imidazoles Adamantane/*analogs & derivatives Receptors, Purinergic P1/antagonists & inhibitors. J Med Chem 1992 Sep 18;35(19):3578-81
purinoceptor RDC7  0   *Receptors, Purinergic P1. Brain Res 1990;519(1-2):333
purinoceptor RDC8  0   *Receptors, Purinergic P1. Brain Res 1990;519(1-2):333
N(6)-cyclopentyladenosine  41552-82-3   Adenosine/*analogs & derivatives Receptors, Purinergic P1/agonists. Naunyn Schmiedebergs Arch Pharmacol 1986;332(2):179

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