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Superantigens

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Definition: Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.  coordinate IM with specific microbe /immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics   
See Also Apoptosis; Clonal Anergy; Receptors, Antigen, T-Cell, alpha-beta
Examples Minor Lymphocyte Stimulatory Antigens
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
toxic shock syndrome toxin 2, Staphylococcus aureus  0   *Superantigens. Infect Immun 1986 Aug;53(2):441-4
SEIP protein, Staphylococcus aureus  0   *Enterotoxins *Superantigens. Infect Immun 2005 Sep;73(9):5540-6
enterotoxin A E-120, Staphylococcal  0   *Enterotoxins Superantigens. J Mol Biol 2003 Nov 7;333(5):893-905
SEQ protein, Staphylococcus aureus  0   *Superantigens. Biochemistry 2002 Nov 26;41(47):14033-40
SpeM protein, Streptococcus pyogenes  0   *Superantigens Zinc Fingers. Infect Immun 2002 Dec;70(12):7095-104
PfiT protein, Pseudomonas fluorescens  0   *Superantigens. Infect Immun 2002 Dec;70(12):6567-75
GR protein, mouse mammary tumor virus  0   *Antigens, Viral *Superantigens. J Virol 2002 Nov;76(21):11172-5
speL protein, Streptococcus pyogenes  0   *Bacterial Proteins *Superantigens. Infect Immun 2002 Jun;70(6):3227-33
SpeJ protein, Streptococcus pyogenes  0   *Bacterial Proteins *Exotoxins *Superantigens. Infect Immun 2001 Mar;69(3):1381-8
enterotoxin I, staphylococcal  0   *Enterotoxins *Superantigens. Infect Immun 1998 Jul;66(7):3337-48
enterotoxin G, staphylococcal  0   *Enterotoxins *Superantigens. Infect Immun 1998 Jul;66(7):3337-48
SEGv enterotoxin  0   *Exotoxins Enterotoxins Superantigens. Microbiol Immunol 2000;44(2):79-88
Staphylococcal enterotoxin H  0   *Enterotoxins Superantigens. J Immunol 1999 Dec 15;163(12):6686-93
ypmB protein, Yersinia pseudotuberculosis  0   *Bacterial Proteins Mitogens Superantigens. FEBS Lett 1997 Aug 11;413(1):174-6
Streptococcus pyogenes mitogen-2  0   *Bacterial Proteins Antigens, Bacterial Mitogens Superantigens. Immunology 1997 Jul;91(3):406-13
IDDMK1,2 22 superantigen, human  0   *Membrane Proteins *Superantigens Diabetes Mellitus, Type 1. Cell 1997 Jul 25;90(2):303-13
Mtv29 protein, mouse  0   *Viral Envelope Proteins Superantigens. Immunogenetics 1997;46(2):163-6
MTV-48 protein, mouse mammary tumor virus  0   *Antigens, Viral *Viral Envelope Proteins Superantigens. Immunogenetics 1996;44(4):319-20
MTV-51 protein, mouse mammary tumour virus  0   *Antigens, Viral *Viral Envelope Proteins Superantigens. Immunogenetics 1996;44(4):319-20
Mtv-7 superantigen, Mouse mammary tumor virus  0   *Antigens, Viral *Membrane Glycoproteins Superantigens. Cell Immunol 1995 Sep;164(2):217-26
Yersinia pseudotuberculosis-derived mitogen  0   *Bacterial Proteins Antigens, Bacterial Mitogens Superantigens. J Immunol 1995 May 15;154(10):5228-34
Mtv-50 protein, Mouse mammary tumor virus  0   *Membrane Glycoproteins *Viral Envelope Proteins Antigens, Viral Minor Lymphocyte Stimulatory Antigens Superantigens. Immunogenetics 1994;40(4):312
M12 protein, Mouse mammary tumor virus  0   *Membrane Glycoproteins *Viral Envelope Proteins Antigens, Viral Mammary Tumor Virus, Mouse Superantigens. J Immunol 1994 Jan 1;152(1):65-71
viral superantigen 23, Mouse mammary tumor virus  0   *Membrane Glycoproteins *Viral Envelope Proteins Antigens, Viral Mammary Tumor Virus, Mouse Superantigens. J Immunol 1994 Jan 1;152(1):65-71
Mycoplasma arthritidis mitogen  0   *Antigens, Bacterial *Superantigens Mitogens Superantigens. J Immunol 1987;139(3):927
enterotoxin E, Staphylococcal  0   *Enterotoxins Staphylococcus aureus Superantigens. Appl Environ Microbiol 1986;51(5):885
stinging nettle lectin  0   *Plant Lectins Superantigens Urtica dioica. Arch Biochem Biophys 1986;249(1):215
enterotoxin C, staphylococcal  39424-54-9   *Enterotoxins Staphylococcus aureus Superantigens. Methods Enzymol 1982;84:254
enterotoxin B, staphylococcal  39424-53-8   *Enterotoxins Staphylococcus aureus Superantigens. Infect Immun 1981;33(2):450
enterotoxin F, Staphylococcal  0   *Bacterial Toxins *Enterotoxins *Superantigens. Lancet 1981;1(8228):1017
erythrogenic toxin  0   *Bacterial Proteins *Exotoxins Cysteine Endopeptidases Pyrogens Superantigens. Pharmacol Ther 1980;11(3):661
enterotoxin A, Staphylococcal  37337-57-8   *Enterotoxins Staphylococcus aureus Superantigens.
Pharma Action Interferon Inducers 		Appl Environ Microbiol 1980;39(6):1134

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