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Receptors, Kainic Acid

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Definition: A class of ionotropic glutamate receptors characterized by their affinity for KAINIC ACID.      Other names Receptors, Kainate; Kainic Acid Receptors; Kainate Receptors; Receptor, Kainic Acid; Receptor, Kainate; Kainic Acid Receptor; Kainate Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(9-iodophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid  0   *Phenanthrenes *Piperazines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem. 2012 Jan 12;55(1):327-41.
Grik4 protein, mouse  0   *Receptors, Kainic Acid. J Cell Biol 2008 Dec 29;183(7):1299-1313
tricholomic acid  0   *Isoxazoles Glycine/*analogs & derivatives Receptors, AMPA/agonists Receptors, Kainic Acid/agonists Receptors, Metabotropic Glutamate/agonists. J Med Chem 2008 Apr 10;51(7):2311-5
1-(2-amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-ylmethyl)-5-methylpyrimidine-2,4-dione  0   Alanine/*analogs & derivatives Uracil/*analogs & derivatives Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem 2007 Apr 5;50(7):1558-70
1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)pyrimidine-2,4-dione  0   Alanine/*analogs & derivatives Uracil/*analogs & derivatives Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem 2006 Apr 20;49(8):2579-92
GRIK4 protein, human  0   *Receptors, Kainic Acid. J Neurochem 1994 Jan;62(1):1-9
GRIK5 protein, human  0   *Receptors, Kainic Acid. J Neurosci 2006 Jun 28;26(26):7014-21
2-(2-amino-2-carboxyethyl)-hexahydrofuro(3,2-b)pyran-2-carboxylic acid  0   *Amino Acids *Bicyclo Compounds, Heterocyclic Receptors, Kainic Acid/antagonists & inhibitors. Mol Pharmacol 2006 Jun;69(6):1849-60
UBP 310  0   Alanine/*analogs & derivatives Thymine/*analogs & derivatives Receptors, Kainic Acid/antagonists & inhibitors. J Neurosci 2006 Mar 15;26(11):2852-61
1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione  0   Alanine/*analogs & derivatives Thymine/*analogs & derivatives Receptors, Kainic Acid/antagonists & inhibitors. J Neurosci 2006 Mar 15;26(11):2852-61
1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)-5-iodopyrimidine-2,4-dione  0   Alanine/*analogs & derivatives Uracil/*analogs & derivatives Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem 2005 Dec 1;48(24):7867-81
6-(4-carboxyimidazol-1-ylmethyl)decahydroisoquinoline-3-carboxylic acid  0   *Carboxylic Acids *Isoquinolines Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem 2002 Sep 26;45(20):4383-6
2-((4-aminophenyl)-(4-methylsemicarbazono)methyl)-4,5-methylenedioxyphenylacetic acid methyl ester  0   *Dioxoles *Semicarbazones Receptors, AMPA/antagonists & inhibitors Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem 2002 Sep 26;45(20):4433-42
ethyl 6-(4-ethoxycarbonylimidazol-1-ylmethyl)decahydroisoquinoline-3-carboxylic ester  0   *Isoquinolines Receptors, Kainic Acid/antagonists & inhibitors. J Med Chem 2002 Sep 26;45(20):4383-6
LY382884  0   *Isoquinolines Receptors, Kainic Acid/antagonists & inhibitors. Nature 1999 Nov 18;402(6759):297-301
3a,5,6,6a-tetrahydro-4H--pyrrolo(3,4-d)isoxazole-3,6-dicarboxylic acid  0   *Isoxazoles Proline/*analogs & derivatives Receptors, N-Methyl-D-Aspartate/agonists Receptors, Kainic Acid/agonists. J Med Chem 1999 Oct 7;42(20):4099-107
3a,5,6,6a-tetrahydro-4H-pyrrolo(3,4-d)isoxazole-3,4-dicarboxylic acid  0   *Isoxazoles *Pyrroles Receptors, AMPA/agonists Receptors, Kainic Acid/agonists. J Med Chem 1998 Sep 24;41(20):3759-62
IEM 1460  0   Adamantane/*analogs & derivatives Receptors, AMPA/antagonists & inhibitors Receptors, Kainic Acid/antagonists & inhibitors. J Physiol (Lond) 1997 Dec 15;505(Pt3):655-63
LY 294486  0   *Isoquinolines *Tetrazoles Receptors, Kainic Acid/antagonists & inhibitors. Nature 1997 Oct 9;389(6651):599-603
Gluk1 kainate receptor  0   *Receptors, Kainic Acid. Eur J Neurosci 1996 Nov;8(11):2379-87
Gluk2 kainate receptor  0   *Receptors, Kainic Acid. Proc Natl Acad Sci U S A 1995 Dec 19;92(26):12090-4
GluK3 kainate receptor  0   *Receptors, Kainic Acid. Receptors Channels 1994;2(4):315-26

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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