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Chloride Channels

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Definition: Cell membrane glycoproteins that form channels to selectively pass chloride ions. Nonselective blockers include FENAMATES; ETHACRYNIC ACID; and TAMOXIFEN.  DF: CL CHANNELS   
Examples Cystic Fibrosis Transmembrane Conductance Regulator; Receptors, GABA-A; Receptors, Glycine 		Other names Ion Channels, Chloride; Chloride Ion Channel; Chloride Channels, Calcium-Activated; Channels, Chlorine; Channels, Chloride Ion; Channels, Chloride; Channels, Calcium-Activated Chloride; Channel, Chloride Ion; Channel, Chloride; Calcium Activated Chloride Channels; Ion Channel, Chloride; Chlorine Channels; Chloride Ion Channels; Chloride Channel; Calcium-Activated Chloride Channels
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
glutamate-gated chloride channel 1, C elegans  0   *Chloride Channels *Caenorhabditis elegans Proteins. Science. 2012 Feb 3;335(6068):574-8
bestrophin-2 protein, rat  0   *Chloride Channels. J Comp Neurol. 2009 Aug 10;515(5):585-99.
bestrophin-3 protein, rat  0   *Chloride Channels. Circ Res. 2008 Oct 10;103(8):864-72.
xANO2 protein, Xenopus  0   *Chloride Channels. Biochem Biophys Res Commun 2011 May 20;408(4):559-65
CLCc protein, Arabidopsis  0   *Chloride Channels *Arabidopsis Proteins. Plant J 2010 Nov;64(4):563-76
TTYH3 protein, mouse  0   *Chloride Channels. J Cyst Fibros 2010 Sep;9(5):351-64
ANO1 protein, rat  0   *Chloride Channels. J Physiol 2010 Jul 1;588(Pt 13):2305-14
ANO5 protein, human  0   *Chloride Channels. Am J Hum Genet 2010 Feb 12;86(2):213-21
CLIC1 protein, rat  0   *Chloride Channels. Bone. 2009 Dec;45(6):1175-85
ClCe protein, Arabidopsis  0   *Chloride Channels *Arabidopsis Proteins. New Phytol 2009;183(1):88-94
Clca4 protein, rat  0   *Chloride Channels. Biol Reprod 2009 Apr;80(4):788-94
TMEM16B protein, mouse  0   *Chloride Channels. Cell 2008 Sep 19;134(6):1019-29
TMEM16A protein, Xenopus  0   *Chloride Channels *Xenopus Proteins. Cell 2008 Sep 19;134(6):1019-29
CLCA4 protein, mouse  0   *Chloride Channels. Am J Physiol Cell Physiol 2008 Jul;295(1):C279-87
TMEM16A protein, mouse  0   *Chloride Channels Biological Markers. Dev Biol 2008 Sep 1;321(1):141-9
TTYH3 protein, human  0   *Chloride Channels. Biochem J 2008 May 15;412(1):45-55
CLIC protein, Drosophila  0   *Chloride Channels *Drosophila Proteins. Proteins 2008 Apr;71(1):364-78
bestrophin-3, Drosophila  0   *Chloride Channels *Drosophila Proteins. J Gen Physiol 2006 Sep;128(3):247-59
bestrophin-2, Drosophila  0   *Chloride Channels *Drosophila Proteins. J Gen Physiol 2006 Sep;128(3):247-59
bestrophin-1, Drosophila  0   *Chloride Channels *Drosophila Proteins. J Gen Physiol 2006 Sep;128(3):247-59
CLIC5 protein, mouse  0   *Chloride Channels. J Neurosci 2006 Oct 4;26(40):10188-98
Best4 protein, mouse  0   *Chloride Channels. FEBS Lett 2006 Apr 3;580(8):2141-6
bestrophin-1 protein, rat  0   *Chloride Channels. Invest Ophthalmol Vis Sci 2004 Oct;45(10):3733-9
ClC protein, E coli  0   *Chloride Channels *Escherichia coli Proteins. EMBO J 2006 Jan 11;25(1):24-33
lubiprostone  0 7-((1R,4R,6R,9R)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo(4.3.0)non-9-yl)heptanoic acid  Alprostadil/*analogs & derivatives Chloride Channels. Drugs R D 2005;6(4):245-8AMITIZA
CLCA protein, rat  0   *Chloride Channels. Biochem Biophys Res Commun 2005 Aug 26;334(2):569-76
Mclc protein, rat  0   *Chloride Channels.
Clcc1 protein, mouse  0   *Chloride Channels.
CLIC1 protein, Xenopus  0   *Chloride Channels.
Clic1 protein, mouse  0   *Chloride Channels.
CLIC1 protein, human  0   *Chloride Channels.
N-(3-bromophenyl)-N'-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)urea  0   *Phenylurea Compounds *Tetrazoles Chloride Channels/antagonists & inhibitors. Am J Pathol 2005 Feb;166(2):467-76
N-(3,5-dichlorophenyl)-N'-(2-(1H-tetrazol-5-yl)biphenyl-4-yl-4'-carboxylic acid dimethylamide)urea  0   *Tetrazoles *Phenylurea Compounds Chloride Channels/antagonists & inhibitors. Am J Pathol 2005 Feb;166(2):467-76
Best-2 protein, mouse  0   *Chloride Channels. J Gen Physiol. 2004 Oct;124(4):371-82
CLCA4 protein, human  0   *Chloride Channels Cystic Fibrosis. Hum Genet. 2004 Nov;115(6):483-91
Clca6 protein, mouse  0   *Chloride Channels. J Biol Chem 2004 Oct 1;279(40):41792-800
CLCA5 protein, mouse  0   *Chloride Channels. J Biol Chem 2004 Oct 1;279(40):41634-41
Clca2 protein, mouse  0   *Chloride Channels.
CLCA1 protein, human  0   *Chloride Channels.
Vmd2L1 protein, mouse  0   *Eye Proteins *Chloride Channels. Cytogenet Genome Res 2004;105(1):107-14
Clcn7 protein, mouse  0   *Chloride Channels.
Clcn7 protein, rat  0   *Chloride Channels.
CLC-6 protein, rat  0   *Chloride Channels.
Clcn6 protein, mouse  0   *Chloride Channels.
clh-6 protein, C elegans  0   *Chloride Channels *Caenorhabditis elegans Proteins.
clcnka protein, Xenopus  0   *Chloride Channels *Xenopus Proteins.
Clcnka protein, mouse  0   *Chloride Channels.
CLCNKA protein, human  0   *Chloride Channels.
Clcnkb protein, mouse  0   *Chloride Channels *Anion Transport Proteins.
Clcnkb protein, rat  0   *Chloride Channels *Anion Transport Proteins.
CLCN4 protein, human  0   *Chloride Channels.
CLIC6 protein, mouse  0   *Chloride Channels. Gene 2003 Nov 27;320:31-40
CLIC6 protein, human  0   *Chloride Channels. Gene 2003 Nov 27;320:31-40
EXC-4 protein, C elegans  0   *Chloride Channels *Caenorhabditis elegans Proteins. Science 2003 Dec 19;302(5653):2134-7
CLIC protein, mouse  0   *Chloride Channels *Mitochondrial Proteins. J Biol Chem 1999 Dec 17;274(51):36488-97
CLIC6 protein, rat  0   *Chloride Channels. Brain Res Mol Brain Res. 2003 Sep 10;117(1):47-57
ANO1 protein, human  0   *Neoplasm Proteins *Chloride Channels. Int J Oncol 2003 Jun;22(6);1375-81
CLC5 protein, mouse  0   *Chloride Channels. Genomics 1999 Jun 15;58(3):281-92
Clic4 protein, rat  0   *Chloride Channels. FEBS Lett 1996 Jul 22;390(2):207-10; J Biol Chem 1997 Sep 19;272(38):23880-6
BEST3 protein, human  0   *Muscle Proteins *Chloride Channels. Eur J Hum Genet 2002 Apr;10(4):281-4
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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