Receptors (definition)

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Receptors, Cytoplasmic and Nuclear

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Definition: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.

general or unspecified; prefer specifics; for hormone receptors, see note at RECEPTORS, CELL SURFACE
Examples Hepatocyte Nuclear Factor 4; Orphan Nuclear Receptors; Peroxisome Proliferator-Activated Receptors; Receptors, Calcitriol; Receptors, Melatonin; Receptors, Retinoic Acid; Receptors, Steroid; Receptors, Thyroid Hormone; Steroidogenic Factor 1

Other names Receptors, Nuclear Hormone; Receptors, Cytoplasmic Hormone; Membrane Receptors, Intracellular; Receptors, Nuclear and Cytoplasmic; Receptors, Nuclear; Receptors, Intracellular Membrane; Receptors, Cytosolic and Nuclear; Receptors, Cytosol and Nuclear; Receptors, Cytoplasmic; Nuclear Receptors; Nuclear Hormone Receptors; Intracellular Membrane Receptors; Cytosol and Nuclear Receptors; Cytoplasmic Receptors; Nuclear and Cytoplasmic Receptors; Hormone Receptors, Nuclear; Hormone Receptors, Cytoplasmic; Cytosolic and Nuclear Receptors; Cytoplasmic and Nuclear Receptors; Cytoplasmic Hormone Receptors

Substance	CAS Registry & name	Categories	Source
FBXO22 protein, human	0	Receptors, Cytoplasmic and Nuclear F-Box Proteins.	Mol Cell Biol 2011 Sep;31(18):3687-99
NHR-80 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	PLoS Biol 2011 Mar;9(3):e1000599
Lpr2 protein, Drosophila	0	Receptors, Cytoplasmic and Nuclear Drosophila Proteins.	PLoS Genet 2011;7(2):e1001297
Lpr1 protein, Drosophila	0	Receptors, Cytoplasmic and Nuclear Drosophila Proteins.	PLoS Genet 2009 Jun;5(6):e1000532
RACK-1 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	PLoS Genet 2010;6(11):e1001215
Rer1 protein, mouse	0	*Receptors, Cytoplasmic and Nuclear.	Proc Natl Acad Sci U S A 2011 Jan 11;108(2):621-5
NHR-64 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	PLoS One 2010;5(3):e9869
TLX protein, rat	0	*Receptors, Cytoplasmic and Nuclear.	Mol Cell Neurosci 2010 Oct;45(2):121-31
Atg34 protein, S cerevisiae	0	Receptors, Cytoplasmic and Nuclear Saccharomyces cerevisiae Proteins Vesicular Transport Proteins.	J Biol Chem 2010 Sep 24;285(39):30019-25
XPO1A protein, Arabidopsis	0	Receptors, Cytoplasmic and Nuclear Karyopherins *Arabidopsis Proteins.	New Phytol. 2010 Jun;186(4):833-42
Fsn protein, Drosophila	0	Receptors, Cytoplasmic and Nuclear Drosophila Proteins.	Mol Cell Biol 2010 Apr;30(7):1769-82
TSPO2 protein, mouse	0	*Receptors, Cytoplasmic and Nuclear.	J Biol Chem 2009 Oct 30;284(44):30484-97
TSPO2 protein, human	0	*Receptors, Cytoplasmic and Nuclear.	J Biol Chem 2009 Oct 30;284(44):30484-97
NHR-31 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	PLoS Genet 2009 Jul;5(7):e1000593
Atg32 protein, S cerevisiae	0	Receptors, Cytoplasmic and Nuclear Saccharomyces cerevisiae Proteins Mitochondrial Proteins.	Dev Cell 2009 Jul;17(1):87-97
NR2E3 protein, Drosophila	0	Receptors, Cytoplasmic and Nuclear Drosophila Proteins.	Dev Dyn 2009 Jan;238(1):171-82
SPDL-1 protein, C elegans	0	Cell Cycle Proteins Caenorhabditis elegans Proteins Receptors, Cytoplasmic and Nuclear.	Genes Dev 2008 Sep 1;22(17):2385-99
Nhr-40 protein, C elegans	0	*Receptors, Cytoplasmic and Nuclear Transcription Factors Zinc Fingers.	Biochem Biophys Res Commun 2008 Sep 12;374(1):49-54
ribosome receptor p180, human	0	*Receptors, Cytoplasmic and Nuclear Microtubule Proteins.	Cell Biol Int 2008 May;32(5):473-83
Pex5R protein, human	0	*Receptors, Cytoplasmic and Nuclear.	Biochim Biophys Acta 2008 May;1783(5):849-63864-73
VSR3 protein, Arabidopsis	0	Receptors, Cytoplasmic and Nuclear Arabidopsis Proteins.	J Exp Bot 2008;59(6):1149-61
C1orf85 protein, human	0	*Receptors, Cytoplasmic and Nuclear.	BMC Mol Biol 2007;8(dup#74);106
Nhr-6 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	Dev Biol 2008 Jan 15;313(2):767-86
RACK1 protein, Drosophila	0	Drosophila Proteins Receptors, Cytoplasmic and Nuclear.	Dev Dyn 2007 Aug;236(8):2207-15
NHR-60 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	Folia Biol (Praha) 2007;53(3):85-96
Nr2e3 protein, Xenopus	0	Receptors, Cytoplasmic and Nuclear Xenopus Proteins Eye Proteins.	Int J Dev Biol 2007;51(3):235-40
RORC protein, zebrafish	0	Receptors, Cytoplasmic and Nuclear Zebrafish Proteins Transcription Factors.	Gene Expr Patterns 2007 Apr;7(5):535-43
RORA protein, zebrafish	0	Receptors, Cytoplasmic and Nuclear Zebrafish Proteins Transcription Factors.	Gene Expr Patterns 2007 Apr;7(5):535-43
Nhr-67 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins Zinc Fingers.	PLoS Genet 2007 Apr 27;3(4):e69
Nr2e3 protein, zebrafish	0	Receptors, Cytoplasmic and Nuclear Zebrafish Proteins.	Gene Expr Patterns 2007 Feb;7(4):521-8
Nr2e1 protein, zebrafish	0	Receptors, Cytoplasmic and Nuclear Zebrafish Proteins.	Gene Expr Patterns 2007 Feb;7(4):521-8
RPN-10 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	Mol Biol Cell 2006 Dec;17(12):5356-71
ERGIC-53 protein, mouse	0	Membrane Proteins Mannose-Binding Lectins Receptors, Cytoplasmic and Nuclear.	Nat Cell Biol 1999 Oct;1(6):330-4
NR5A2 protein, zebrafish	0	Receptors, Cytoplasmic and Nuclear Zebrafish Proteins.
matefin protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	Proc Natl Acad Sci U S A 2006 Sep 5;103(36):13397-402
Kel-8 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins Nerve Tissue Proteins.	Mol Biol Cell 2006 Mar;17(3):1250-60
INP2 protein, S cerevisiae	0	Membrane Proteins Receptors, Cytoplasmic and Nuclear *Saccharomyces cerevisiae Proteins.	Dev Cell 2006 May;10(5):587-600
Tom20 protein, rat	0	Receptors, Cytoplasmic and Nuclear Mitochondrial Proteins.	J Cell Sci. 2005 Sep 1;118(Pt 17):3985-95
NHR-49 protein, C elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins.	Proc Natl Acad Sci U S A 2005 Sep 20;102(38):13496-501
HR4 protein, Drosophila	0	Receptors, Cytoplasmic and Nuclear Drosophila Proteins.	Cell 2005 Jun 3;121(5):773-84
Nvj1 protein, S cerevisiae	0	Receptors, Cytoplasmic and Nuclear Saccharomyces cerevisiae Proteins.	J Cell Sci 2004 Oct 1;117(Pt 21):4959-68
Nr1d2 protein, mouse	0	Repressor Proteins Receptors, Cytoplasmic and Nuclear DNA-Binding Proteins.	J Biol Chem 2005 Mar 11;280(10):8651-9
Xtll protein, Xenopus	0	Receptors, Cytoplasmic and Nuclear Xenopus Proteins.
Nr2e1 protein, mouse	0	*Receptors, Cytoplasmic and Nuclear.
ING2 protein, Xenopus	0	Receptors, Cytoplasmic and Nuclear Homeodomain Proteins Tumor Suppressor Proteins Xenopus Proteins.
PSE1 protein, S cerevisiae	0	Receptors, Cytoplasmic and Nuclear Membrane Transport Proteins *Saccharomyces cerevisiae Proteins.	J Cell Sci 1992 Mar;101( Pt 3):709-19
TRN1 protein, Arabidopsis	0	Receptors, Cytoplasmic and Nuclear Arabidopsis Proteins.	Plant Mol Biol 2003 Sep;53(1-2):201-12
Dnajc7 protein, mouse	0	*Receptors, Cytoplasmic and Nuclear.	Mol Pharmacol. 2003 Nov;64(5):1069-75
TBL1XR1 protein, human	0	Nuclear Proteins Repressor Proteins *Receptors, Cytoplasmic and Nuclear.	EMBO J 2003 Mar 17;22(6):1336-46
TOM70 protein, rat	0	Receptors, Cytoplasmic and Nuclear Mitochondrial Proteins.	J Cell Sci 2002 May 1;115(Pt 9):1895-905
IPO7 protein, human	0	Karyopherins Receptors, Cytoplasmic and Nuclear.	J Biol Chem 2002 Sep 6;277(36):32480-9
Hse1 protein, S cerevisiae	0	Receptors, Cytoplasmic and Nuclear Saccharomyces cerevisiae Proteins *Endosomal Sorting Complexes Required for Transport.	Nat Cell Biol 2002 Jul;4(7):534-9
farnesoid X receptor-like orphan receptor, Xenopus	0	Receptors, Cytoplasmic and Nuclear Xenopus Proteins.	J Biol Chem 2002 May 17;277(20):17836-44
SmRXR-1 protein, Schistosoma mansoni	0	Helminth Proteins Receptors, Cytoplasmic and Nuclear.	J Parasitol 2002 Feb;88(1):3-13
NHR-7 protein, Dirofilaria immitis	0	Helminth Proteins Receptors, Cytoplasmic and Nuclear.	Mol Biochem Parasitol 2002 Feb;119(2):169-77
mammalian p180	0	*Receptors, Cytoplasmic and Nuclear.	Traffic 2001 Oct;2(10):705-16
ING2 protein, human	0	Receptors, Cytoplasmic and Nuclear Homeodomain Proteins *Tumor Suppressor Proteins.	Cell. 2003 Jul 11;114(1):99-111; J Biol Chem 2001 Dec 14;276(50):47013-20
nhr-8 protein, C-elegans	0	Receptors, Cytoplasmic and Nuclear Caenorhabditis elegans Proteins Transcription Factors.	Curr Biol 2001 Jun 5;11(11):864-8
PNRC2 protein, human	0	Trans-Activators Receptors, Cytoplasmic and Nuclear.	Nucleic Acids Res 2001 Oct 1;29(19):3939-48
soluble guanylyl cyclase	EC 4.6.1.2	Guanylate Cyclase Receptors, Cytoplasmic and Nuclear.	Brain Res 2001 Jul 13;907(1-2):54-60

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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