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Receptors, Calcitriol

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Definition: Proteins, usually found in the cytoplasm, that specifically bind calcitriol, migrate to the nucleus, and regulate transcription of specific segments of DNA with the participation of D receptor interacting proteins (called DRIP). Vitamin D is converted in the liver and kidney to calcitriol and ultimately acts through these receptors.  DF: RECEPT CALCITRIOL    Other names Vitamin D Receptors; Vitamin D 3 Receptors; Receptors, Vitamin D; Cholecalciferol Receptors; Calcitriol Receptors; Receptors, 1,25-Dihydroxyvitamin D3; Receptors, 1,25-Dihydroxycholecalciferol; Receptor, Vitamin D3; Receptor, Vitamin D; Receptor, 1,25-Dihydroxyvitamin D3; Receptor, 1,25-Dihydroxycholecalciferol; Receptor, Calcitriol; D3 Receptors, Vitamin; D3 Receptors, 1,25-Dihydroxyvitamin; D3 Receptor, Vitamin; D3 Receptor, 1,25-Dihydroxyvitamin; D Receptors, Vitamin; D Receptor, Vitamin; 1,25 Dihydroxyvitamin D3 Receptors; 1,25 Dihydroxyvitamin D3 Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(2-aminophenyl)-6-(4-(2-(3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-4-methylhepta-2,4-dienamide  0   *Anilides Calcitriol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors. J Med Chem 2010 Oct 28;53(20):7461-5
CH 5036249  0   *Benzhydryl Compounds *Pyridines Receptors, Calcitriol/agonists. J Steroid Biochem Mol Biol 2010 Jul;121(1-2):204-7
1,25-dihydroxy-6-methylvitamin D3  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors. J Steroid Biochem Mol Biol 2010 Jul;121(1-2):29-33
22-butyl-1,24-dihydroxy-24,25,26-trinorvitamin D3  0   Cholecalciferol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors Receptors, Calcitriol/agonists. J Med Chem 2009 Mar 12;52(5):1438-49
22-butyl-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/agonists. J Med Chem 2007 Mar 8;50(5):932-9
22-ethyl-1,25-dihydroxyvitamin D3  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/agonists. J Med Chem 2007 Mar 8;50(5):932-9
2-(3-hydroxypropoxy)-24-propylvitamin D3-26,23-lactone  0   Cholecalciferol/*analogs & derivatives Receptors, Calcitriol. J Med Chem 2006 Nov 30;49(24):7063-75
Ro43 83582  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/agonists. J Biol Chem 2006 Apr 14;281(15):10516-26
LY 2109866  0   *Acetic Acids *Thiophenes Receptors, Calcitriol/agonists. J Clin Invest 2006 Apr;116(4):892-904
LY 2108491  0   *Arylsulfonates *Thiophenes Receptors, Calcitriol/agonists. J Clin Invest 2006 Apr;116(4):892-904
lithocholic acid acetate  0   Lithocholic Acid/*analogs & derivatives Receptors, Calcitriol/agonists. J Lipid Res 2005 Jan;46(1):46-57
ZK 191732  0   *Thiazoles Receptors, Calcitriol/antagonists & inhibitors. Biochem Biophys Res Commun 2001 Nov 2;288(3):690-6
ZK 168281  0   Calcitriol/*analogs & derivatives Receptors, Calcitriol/antagonists & inhibitors. Chem Biol 2000 Nov;7(11):885-94
CD 2809  0   *Receptors, Calcitriol Ligands. Biochem Pharmacol 1998 Mar 15;55(6):767-73
1,24-dihydroxycholecalciferol receptor  0   *Receptors, Calcitriol Dihydroxycholecalciferols. Steroids 1982;39(1):53
24,25-dihydroxycholecalciferol receptor  0   *Receptors, Calcitriol. Biochem Biophys Res Commun 1981;100(2):551
25-hydroxycholecalciferol receptor  0   *Receptors, Calcitriol. Methods Enzymol 1980;67:479

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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