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Receptors, Thrombin

More information in Books or onNLM PubMed
Definition: A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.  DF: RECEPT THROMBIN   
Examples Platelet Glycoprotein GPIb-IX Complex; Receptor, PAR-1; Thrombomodulin 		Other names Thrombin Receptors; Receptor, Thrombin; Peptide, TRAP; Thrombin Receptor Activator Peptide; Thrombin Receptor Activating Peptides; Thrombin Receptor Activating Peptide Ligand; Thrombin Receptor; TRAP Peptide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
solulin protein  0   *Recombinant Proteins *Receptors, Thrombin. Thromb Haemost 2011 Feb 1;105(2):302-12
E 5555  0   *Imines *Pyridines Receptors, Thrombin/antagonists & inhibitors. Recent Pat Cardiovasc Drug Discov 2009 Jan;4(1):55-60
vorapaxar  0   *Lactones *Pyridines Receptors, Thrombin/antagonists & inhibitors Receptor, PAR-1/antagonists & inhibitors. J Med Chem 2008 Jun 12;51(11):3061-4
decahydro-7-hydroxy-3-methyl-4-(2-(5-(3-(trifluoromethyl)phenyl)-2-pyridinyl)ethenyl)naphtho(2,3-c)furan-1(3H)-one  0   *Heterocyclic Compounds, 3-Ring *Pyridines Receptors, Thrombin/antagonists & inhibitors. J Med Chem 2007 Jan 11;50(1):129-38
4-(5-(3-trifluoromethylphenyl)pyridin-2-yl)ethenyl-3-methyldecahydronaphtho(2,3-c)furan-1(3H)-one  0   *Heterocyclic Compounds, 3-Ring *Pyridines Receptors, Thrombin/antagonists & inhibitors. Proc Natl Acad Sci U S A 2005 Sep 20;102(38):5884-7
N-cinnamoyl-4-fluorophenylalanyl-4-guanidinophenylalanyl-leucyl-arginyl-argininamide  0   *Guanidines *Oligopeptides Receptors, Thrombin/antagonists & inhibitors. J Med Chem 1996 Dec 6;39(25):4879-87
5-(3-(hexahydroazepin-1-yl)propyl)(benzodioxol-5-yl)amino-3-(3,5-difluorophenyl)isoxazole  0   *Azepines *Isoxazoles Receptors, Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 2002 Feb 11;12(3):319-23
RWJ-56110  0   *Indazoles Urea/*analogs & derivatives Receptors, Thrombin. Bioorg Med Chem Lett 2001 Aug 20;11(16):2105-9
RWJ-53052  0   *Indazoles Urea/*analogs & derivatives Receptors, Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Aug 20;11(16):2105-9
RWJ 58259  0   *Indazoles Urea/*analogs & derivatives Receptors, Thrombin/antagonists & inhibitors. J Med Chem 2001 Mar 29;44(7):1021-4
eryloside F  0   *Saponins Receptors, Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 2000 Apr 3;10(7):661-4
FR 171113  0   *Benzamides *Thiazolidines Receptors, Thrombin/antagonists & inhibitors. Eur J Pharmacol 1999 Nov 19;384(2-3):197-202
N-cinnamoyl-p-fluorophenylalanyl-p-guanidinophenylalanyl-leucyl-argininamide  0   *Guanidines *Oligopeptides Receptors, Thrombin/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jan 18;9(2):279-84
SFLLRNPND  0   *Peptide Fragments Receptors, Thrombin. Br J Pharmacol 1999 Jan;126(2):478-84
1-(6-guanidohexanoyl)-4-(phenylacetylaminomethyl)piperidine  0   *Piperidines Receptors, Thrombin/antagonists & inhibitors. Amino Acids 1998;15(3):211-20
1-phenylacetyl-4-(6-guanidohexanoyl)piperazine  0   *Piperazines Receptors, Thrombin/antagonists & inhibitors. Amino Acids 1998;15(3):211-20
protease-activated receptor 4  0   *Receptors, Thrombin. Proc Natl Acad Sci U S A 1998 Jun 9;95(12):6642-6
thrombin receptor peptide (1-41)  0   *Peptide Fragments Receptors, Thrombin. Pro Natl Acad Sci U S A 1998 Mar 17;95(6):3082-7
protease-activated receptor 3  0   *Receptors, Thrombin. Nature 1997 Apr 3;386(6624):502-6
seryl-leucyl-isoleucyl-glycyl-arginyl-leucine  0   *Oligopeptides Receptors, Thrombin. Circ Res 1996 Apr;78(4):581-8
thrombin receptor-activating peptide SFLLRNPNDKY  0   *Oligopeptides Receptors, Thrombin. J Am Cell Cardiol 1995 Dec;26(7):1665-71
aplysillin A  0   *Phenols *Sulfuric Acid Esters Receptors, Thrombin/antagonists & inhibitors. J Nat Prod 1995 Jun;58(6):954-7
thrombin receptor peptide 14  0   *Peptide Fragments Receptors, Thrombin. J Cell Physiol 1994 Sep;160(3):573-84
seryl-phenylalanyl-phenylalanyl-leucyl-arginyl-asparaginyl-proline  140436-66-4   *Oligopeptides Receptors, Thrombin. Am J Physiol 1994 Aug;267(2 Pt 1):L113-9
thrombin receptor peptide (42-47)  0   *Peptide Fragments Receptors, Thrombin. Biochem J 1993 Aug 15;294(Pt 1):253-60
thrombin receptor peptide (42-55)  137339-65-2   *Peptide Fragments Receptors, Thrombin. Biochem Biophys Res Commun 1991;181(2):636

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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