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Drug Resistance, Multiple

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Definition: Simultaneous resistance to several structurally and functionally distinct drugs.  DRUG RESISTANCE, MULTIPLE, BACTERIAL; DRUG RESISTANCE, MULTIPLE, VIRAL; and DRUG RESISTANCE, MULTIPLE, FUNGAL are also available   
See Also Genes, MDR; Multidrug Resistance-Associated Proteins; P-Glycoproteins
Examples Drug Resistance, Multiple, Bacterial; Drug Resistance, Multiple, Fungal; Drug Resistance, Multiple, Viral 		Other names Multidrug Resistance; Resistance, Multiple Drug; Multiple Drug Resistance; Multi-Drug Resistance
 
SubstanceCAS Registry & nameCategoriesSource
murucoidin V  0   *Glycosides Drug Resistance, Multiple/drug effects. J Nat Prod. 2012 Jan 27;75(1):93-7
small multidrug-resistance pump, Staphylococcus aureus  0   *Antiporters Drug Resistance, Multiple. J Biol Chem 1994 Nov 25;269(47):29998-30004
2-(N-(4-methoxyphenylethylaminocarbonyl))-5-hydroxychromone  0   *Chromones Drug Resistance, Multiple Drug Resistance, Neoplasm. J Med Chem 2005 Nov 17;48(23):7275-81
2-(N-(3,4-dimethoxyphenylethylaminocarbonyl))-5-hydroxychromone  0   *Chromones Drug Resistance, Multiple Drug Resistance, Neoplasm. J Med Chem 2005 Nov 17;48(23):7275-81
2-(4-n-butylpiperazin-1-ylcarbonyl)-5-hydroxychromone  0   *Chromones *Piperazines Drug Resistance, Multiple Drug Resistance, Neoplasm. J Med Chem 2005 Nov 17;48(23):7275-81
Abcc5 protein, mouse  0   *Multidrug Resistance-Associated Proteins Drug Resistance, Multiple.
ATMRP5 protein, Arabidopsis  0   *Multidrug Resistance-Associated Proteins *Arabidopsis Proteins Drug Resistance, Multiple.
Abcc4 protein, rat  0   *Multidrug Resistance-Associated Proteins Drug Resistance, Multiple.
ArpC protein, Pseudomonas putida  0   *Bacterial Proteins *Membrane Transport Proteins Drug Resistance, Multiple. Microbiology 2001 Jan;147(Pt 1):43-51
ArpB protein, Pseudomonas putida  0   *Bacterial Proteins *Membrane Transport Proteins Drug Resistance, Multiple. Microbiology 2001 Jan;147(Pt 1):43-51
ArpA protein, Pseudomonas putida  0   *Bacterial Proteins *Carrier Proteins Drug Resistance, Multiple. Microbiology 2001 Jan;147(Pt 1):43-51
TtgI protein, Pseudomonas putida  0   *Bacterial Proteins *Membrane Transport Proteins Drug Resistance, Multiple. J Bacteriol 2001 Jul;183(13):3967-73
POHL protein, marine sponge  0   *Trans-Activators Drug Resistance, Multiple. Environ Toxicol Chem 2001 Jan;20(1):198-204
multidrug resistance-associated protein 1  0   *Multidrug Resistance-Associated Proteins Drug Resistance, Multiple.
4-deacetoxyagosterol  0   *Sterols Drug Resistance, Multiple. Bioorg Med Chem Lett 2000 Nov 20;10(22):2521-4
7-O-benzoylpyripyropene A  0   *Pyridones *Sesquiterpenes Drug Resistance, Multiple. J Antibiot (Tokyo) 2000 Oct;53(10):1201-6
FLU1 protein, Candida albicans  0   *Fungal Proteins *Drug Resistance, Multiple *ATP-Binding Cassette Transporters. Microbiology 2000 Nov;146 ( Pt 11):2743-54
RAB6C protein, human  EC 3.6.1.-   *rab GTP-Binding Proteins Drug Resistance, Multiple. Gene 2000 Oct 17;257(1):67-75
R 101933  0   *Benzazepines *Quinolines Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Clin Cancer Res 2000 Apr;6(4):1365-71
OC 144-093  0   *Imidazoles Drug Resistance, Multiple. Cancer Res 2000 Jun 1;60(11):2964-72
doxorubicin-gallium-transferrin conjugate  0   *Doxorubicin *Organometallic Compounds *Transferrin Gallium Drug Resistance, Multiple. Anticancer Res 2000 Mar-Apr;20(2A):799-808
MEF1 protein, human  0   *DNA-Binding Proteins *Transcription Factors Genes, MDR Drug Resistance, Multiple. Biochemistry 2000 Jan 11;39(1):194-204
CP 147673  0   *Piperazines Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Biochemistry 2000 Jan 11;39(1):75-85
CP 172732  0   *Piperazines *Thiazoles Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Biochemistry 2000 Jan 11;39(1):75-85
CP 162398  0   *Piperazines *Quinolines Drug Resistance, Multiple P-Glycoprotein/antagonists & inhibitors. Biochemistry 2000 Jan 11;39(1):75-85
MexXY protein, Pseudomonas aeruginosa  0   *Bacterial Proteins Drug Resistance, Multiple. Antimicrob Agents Chemother 1999 Nov;43(11):2624-8
LY 329146  0   *Sulfonamides *Thiophenes Drug Resistance, Multiple. Bioorg Med Chem Lett 1999 Dec 6;9(23):3381-6
B 4121  0   Clofazimine/*analogs & derivatives Drug Resistance, Multiple. Oncol Rep 2000 Jan-Feb;7(1):193-5
tariquidar  206873-63-4   *Quinolines Drug Resistance, Multiple. Br J Pharmacol 1999 Sep;128(2):403-11
ABCC5 protein, human  0   *Multidrug Resistance-Associated Proteins Drug Resistance, Multiple. Cancer Res 1997 Aug 15;57(16):3537-47
9-hydroxy-2-(2-(dimethylamino)ethyl)-6-((2-(dimethylamino)ethyl)amino)-2,3-dihydro-1H,7H-pyrimido(5,6,1-de)acridine-1,3,7-trione  0   *Acridines *Pyrimidinones Drug Resistance, Multiple Drug Resistance, Neoplasm. J Med Chem 1999 Jul 15;42(14):2535-41
9-amino-2-(2-(dimethylamino)ethyl)-6-((2-(dimethylamino)ethyl)amino)-2,3-dihydro-1H,7H-pyrimido(5,6,1-de)acridine-1,3,7-trione  0   *Acridines *Pyrimidinones Drug Resistance, Multiple Drug Resistance, Neoplasm. J Med Chem 1999 Jul 15;42(14):2535-41
6-((2-aminoethyl)amino)-2-(2-(dimethylamino)ethyl)-2,3-dihydro-1H,7H-pyrimido(5,6,1-de)acridine-1,3,7-trione  0   *Acridines *Pyrimidinones Drug Resistance, Multiple Drug Resistance, Neoplasm. J Med Chem 1999 Jul 15;42(14):2535-41
reversin 205  0   *Oligopeptides Drug Resistance, Multiple. Biochem Pharmacol 1999 Aug 15;58(4):571-86
reversin 121  0   *Oligopeptides Drug Resistance, Multiple. Biochem Pharmacol 1999 Aug 15;58(4):571-86
MM 36  0   *Anisoles *Nitriles Drug Resistance, Multiple Drug Resistance, Neoplasm. J Med Chem 1999 May 20;42(10):1687-97
multidrug resistance-associated protein 2  0   *Multidrug Resistance-Associated Proteins Jaundice, Chronic Idiopathic Drug Resistance, Multiple. Mol Pharmacol 1999 May;55(5):929-37
MexA protein, Pseudomonas aeruginosa  0   *Bacterial Outer Membrane Proteins *Membrane Transport Proteins Drug Resistance, Multiple. J Bacteriol 1993 Nov;175(22):7363-72
MexB protein, Pseudomonas aeruginosa  0   *Bacterial Outer Membrane Proteins *Membrane Transport Proteins Drug Resistance, Multiple. J Bacteriol 1993 Nov;175(22):7363-72
GP-88, propafenone-type MDR-modulator  0   *Phenyl Ethers *Propanols Drug Resistance, Multiple. Bioorg Med Chem Lett 1998 Apr 7;8(7):829-32
ABCG2 protein, human  0   *Neoplasm Proteins *ATP-Binding Cassette Transporters Drug Resistance, Multiple. Biochem Pharmacol. 2005 Jun 23; Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15665-70
Tap protein, Mycobacterium  0   *Bacterial Proteins *Membrane Transport Proteins Drug Resistance, Microbial Drug Resistance, Multiple. J Bacteriol 1998 Nov;180(22):5836-43
Pmr1 protein, bacteria  0   *Bacterial Proteins *ATP-Binding Cassette Transporters Drug Resistance, Multiple. Appl Environ Microbiol 1998 Oct;64(10):3983-8
multidrug resistance-associated protein 3  0   *Multidrug Resistance-Associated Proteins Drug Resistance, Multiple. FEBS Lett 1998 Aug 14;433(1-2):149-52
ATPGP2 protein, Arabidopsis  0   *ATP-Binding Cassette Transporters *Arabidopsis Proteins Drug Resistance, Multiple. Methods Enzymol 1998;292:162-73
ATPGP1 protein, Arabidopsis  0   *ATP-Binding Cassette Transporters *Arabidopsis Proteins Drug Resistance, Multiple. Methods Enzymol 1998;292:162-73
qacH protein, Staphylococcus saprophyticus  0   *Bacterial Proteins *Membrane Transport Proteins Drug Resistance, Multiple. FEMS Microbiol Lett 1998 Jan 1;163(1):49-56
hapalosin  159542-04-8   *Lactams *Lactones *Depsipeptides Drug Resistance, Multiple. J Med Chem 1998 Mar 12;41(6):981-7
MDR1 protein, Filobasidiella neoformans  0   *Fungal Proteins *ATP-Binding Cassette Transporters Cryptococcus neoformans Drug Resistance, Multiple. Gene 1997 Nov 12;201(1-2):21-9
HIPK3 protein, human  EC 2.7.11.1   *Protein-Serine-Threonine Kinases *Intracellular Signaling Peptides and Proteins Drug Resistance, Multiple. Gene 1997 Oct 24;200(1-2):35-43; J Biol Chem 1998 Oct 2;273(40):25875-9
AadB protein, Acinetobacter sp. SUN  0   *Bacterial Proteins Drug Resistance, Multiple. FEMS Microbiol Lett 1997 Aug 15;153(2):321-6
VA 033  0   *Vinca Alkaloids Drug Resistance, Multiple. Eur J Pharmacol 1997 May 30;327(2-3):239-46
VX 710  0   *Piperidines *Pyridines Drug Resistance, Multiple. Anticancer Drugs 1997 Feb;8(2):125-40
LmrA protein, Lactococcus lactis  0   *Bacterial Proteins *Multidrug Resistance-Associated Proteins Drug Resistance, Multiple. Proc Natl Acad Sci U S A 1996 Oct 1;93(20):10668-72
QacB protein, Staphylococcus aureus  0   *Bacterial Proteins *Membrane Transport Proteins Drug Resistance, Multiple. Proc Natl Acad Sci U S A 1996 Apr 16;93(8):3630-5
BmrR protein, bacteria  0   *Bacterial Proteins *Trans-Activators DNA-Binding Proteins Drug Resistance, Microbial Drug Resistance, Multiple. J Biol Chem 1994 Nov 11;269(45):28506-13
LfrA protein, Mycobacterium smegmatis  0   *Bacterial Proteins *Antiporters Drug Resistance, Multiple. Proc Natl Acad Sci U S A 1996 Jan 9;93(1):362-6
RamA protein, Klebsiella  0   *Bacterial Proteins Drug Resistance, Multiple. Microbiology 1995 Aug;141( Pt 8):1909-20
zosuquidar trihydrochloride  0   *Dibenzocycloheptenes *Quinolines Drug Resistance, Multiple. Anticancer Res 1995 May-Jun;15(3):811-4
multidrug resistance protein 3  0   *P-Glycoproteins Drug Resistance, Multiple. Hematol Oncol Clin North Am 1995 Apr;9(2):239-49
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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