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GABA Antagonists

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Definition: Drugs that bind to but do not activate GABA RECEPTORS, thereby blocking the actions of endogenous GAMMA-AMINOBUTYRIC ACID and GABA RECEPTOR AGONISTS.  note specifics; do not confuse with GABA AGONISTS   
Examples GABA-A Receptor Antagonists; GABA-B Receptor Antagonists 		Other names gamma Aminobutyric Acid Antagonists; Receptor Antagonists, GABA; Antagonists, gamma-Aminobutyric Acid; Antagonists, GABA Receptor; Antagonists, GABA; Antagonist, GABA; Acid Antagonists, gamma-Aminobutyric; GABA Receptor Antagonists; GABA Antagonist; gamma-Aminobutyric Acid Antagonists
Substances having this pharmacologic action: bicuculline methochloride; RU 5135; 2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; FG 7142; ZK 93426; Picrotoxin; Clozapine; Pentylenetetrazole; Allylglycine; (3-aminopropyl)(n-butyl)phosphinic acid; NNC 711; saclofen; CGP 55845A; CGP 35348; gabazine; phaclofen
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tutin  2571-22-4 (1aS-(1a alpha,1b beta,2 beta,5 beta,6 alpha,6a beta,7 beta,7a alpha,8S*))-hexahydro-1b,6-dihydroxy- 6a-methyl-8-(1-methylethenyl)spiro(2,5-methano-7H- oxireno(3,4)cyclopent(1,2-d)oxepin-7,2'-oxiran)- 3(2 alpha H)-one  *Sesquiterpenes Picrotoxin/*analogs & derivatives GABA Antagonists.
7-oxodehydroepiandrosterone  566-19-8 3 beta-hydroxyandrost-5-ene-7,17-dione  Dehydroepiandrosterone/*analogs & derivatives Receptors, GABA-A GABA Antagonists. Steroid Lipid Res 3(2):170;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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