Definition: Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
POLYMORPHISM, SINGLE NUCLEOTIDE is also available
Other names Polymorphisms, Single-Stranded Conformational; Polymorphism, Single Stranded Conformational; Conformational Polymorphisms, Single-Stranded; Conformational Polymorphism, Single-Stranded; Single-Stranded Conformational Polymorphisms; Single Stranded Conformational Polymorphism; Single-Stranded Conformational Polymorphism; SSCP
