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Opioid Peptides

More information in Books or onNLM PubMed
Definition: The endogenous peptides with opiate-like activity. The three major classes currently recognized are the ENKEPHALINS, the DYNORPHINS, and the ENDORPHINS. Each of these families derives from different precursors, proenkephalin, prodynorphin, and PRO-OPIOMELANOCORTIN, respectively. There are also at least three classes of OPIOID RECEPTORS, but the peptide families do not map to the receptors in a simple way.     
Pharmacological Action Neurotransmitter Agents
See Also Receptors, Opioid
Examples Dynorphins; Endorphins; Enkephalins 		Other names Peptides, Opioid; Peptides, Opiate; Peptide, Opioid; Opioid Peptide; Opiate Peptides; Endogenous Opiates; Opiates, Endogenous
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
nociceptin(1-13)NH2, Orn(9)  0   *Peptide Fragments *Opioid Peptides. Cell Biochem Funct 2009 Jun;27(4):243-50
nociceptin-amide, Nphe(1)-(pF)Phe(4)-Aib(7)-Arg(14)-Lys(15)  0   *Opioid Peptides. Peptides 2007 Oct;28(10):1974-81
cyclo(Cys(7,14))nociceptin (1-13) amide  0   *Peptides, Cyclic *Opioid Peptides. Naunyn Schmiedebergs Arch Pharmacol 2007 Aug;375(6):369-76
nociceptin-amide, Nphe(1)-(pF)Phe(4)-Aib(7,11)-Arg(14)-Lys(15)  0   *Opioid Peptides. Regul Pept 2006 May 15;134(2-3):75-81
nociceptin-amide, (pF)Phe(4)-Aib(7,11)-Arg(14)-Lys(15)  0   *Opioid Peptides. Regul Pept 2006 May 15;134(2-3):75-81
nociceptin (1-17)amide, Arg(14)-Lys(DTPA)(15)  0   *Peptide Fragments *Opioid Peptides. Peptides 2005 Jul;26(7):1159-66
nociceptin-orphanin FQ-amide, phenylalanyl(1)-psi(CH2NH)-glycyl(2)-4-fluorophenylalanyl(4)-arginyl(14)-lysyl(15)  0   *Opioid Peptides Ligands. J Med Chem 2005 Mar 10;48(5):1421-7
UFP-102  0   *Opioid Peptides. J Pharmacol Exp Ther. 2005 Mar;312(3):1114-23
(Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)  0   *Opioid Peptides. Naunyn Schmiedebergs Arch Pharmacol 2003 Feb;367(2):183-7
nociceptin (1-13), Phe(1)psi(CH2-O)Gly(2)  0   *Peptide Fragments *Opioid Peptides. Neurosci Lett. 2003 Aug 7;346(3):145-8
nociceptin orphanin FQ(1-17)OH  0   *Peptide Fragments *Opioid Peptides Ligands. Neurosci Lett;2002 Aug 2;328(1):5-8
prepro-orphanin FQ (154-181)  0   *Peptide Fragments *Opioid Peptides. J Pharmacol Exp Ther 2002 Jan;300(1):257-64
nociceptin, Arg(14)-Lys(15)  0   *Opioid Peptides. J Pharmacol Exp Ther 2002 Jan;300(1):57-63
cyclo(Cys(10,14))nociceptin (1-13) amide  0   *Peptides, Cyclic *Opioid Peptides. J Med Chem 2001 Nov 8;44(23):4015-8
nociceptin (1-13) amide  0   *Peptide Fragments *Opioid Peptides. J Med Chem 2001 Nov 8;44(23):3956-64
FE 200666  0   *Opioid Peptides. Anesthesiology 2001 Jun;94(6):1034-44
FE 200665  0   *Opioid Peptides. Anesthesiology 2001 Jun;94(6):1034-44
dermorphin-saporin  0   *Opioid Peptides *Ribosome Inactivating Proteins, Type 1. J Neurosci 2001 Jul 15;21(14):5281-8
prepro-orphanin FQ(160-187)  0   *Peptide Fragments *Opioid Peptides. Brain Res 2001 Mar 23;895(1-2):89-94
(F-G)NOC oFQ(1-13)-NH2  0   *Peptide Fragments *Opioid Peptides. Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2188-95
phylloxin  0   *Peptides Protein Precursors Opioid Peptides. Eur J Biochem 2000 Jan;267(2):370-8
nociceptin (1-17)-NH2, Phe(1)-psi(CH2NH)-Gly(2)  0   *Peptide Fragments *Opioid Peptides. Neurosci Lett 2000 Jan 7;278(1-2):109-12
nociceptin-(1-13)-NH2, NPhe(1)  0   *Peptide Fragments *Opioid Peptides. Eur J Pharmacol 1999 Dec 3;385(2-3):R3-R5
nociceptin (1-11)  0   *Peptide Fragments *Opioid Peptides. Peptides 1999;20(2):239-47
nociceptin (1-6)  0   *Peptide Fragments *Opioid Peptides. Peptides 1999;20(2):239-47
proorphanin  0   *Protein Precursors *Opioid Peptides. Gen Comp Endocrinol 1999 Feb;113(2):169-86
nociceptin (1-13)-NH2, Phe(1)-psi(CH2-NH)-Gly(2)  0   *Peptide Fragments *Opioid Peptides Receptors, Opioid/antagonists & inhibitors Receptors, Opioid/agonists. Eur J Pharmacol 1998 May 15;349(1):R5-R6
exorphin C  0   *Hemoglobins *Peptide Fragments Glutens Opioid Peptides. Biull Eksp Biol Med 1998 Feb;125(2):153-7
nocistatin  0   *Opioid Peptides.
Pharma Action Analgesics, Opioid 		Nature 1998 Mar 19;392(6673):286-9
nociceptin, Tyr(1)  0   *Opioid Peptides Receptors, Opioid/agonists. Biochem Biophys Res Commun 1997 May 19;234(2):309-12
nociceptin  0   *Opioid Peptides Receptors, Opioid/agonists Excitatory Amino Acids/agonists.
Pharma Action Vasodilator Agents 		Nature 1995 Oct 12;377(6549):476; Science 1995 Nov 3;270(5237):792-4
opiomelanin  0   *Melanins *Opioid Peptides. Biochim Biophys Acta 1995 Jan 18;1243(1):71-7
acetyl-arginyl-phenylalanyl-tryptophyl-isoleucyl-asparaginyl-lysine  0   *Opioid Peptides. Science 1994 Dec 23;266(5193):2019-22
deltorphin, Leu(2)  154722-68-6   *Opioid Peptides. Peptides 1994;15(2):199-202
hemorphin 7  152685-85-3 L-Phenylalanine, N-(N2-(N2-(N-(N-(1-L-tyrosyl-L-prolyl)-L-tryptophyl)-L-threonyl)-L-glutaminyl)-L-arginyl)  *Hemoglobins *Peptide Fragments Opioid Peptides. Regul Pept 1993 Nov 19;49(1):9-18
spinorphin  137201-62-8 L-Threonine, N-(N-(1-(N-(N-(N-L-leucyl-L-valyl)-L-valyl)-L-tyrosyl)-L-prolyl)-L-tryptophyl)  *Oligopeptides Neprilysin/antagonists & inhibitors Opioid Peptides. Biochem Biophys Res Commun 1993 Jul 30;194(2):713-9
LVV-hemorphin 6  0   *Hemoglobins *Peptide Fragments Peptidyl-Dipeptidase A/antagonists & inhibitors Opioid Peptides. FEBS Lett 1991;287(1-2):39
hemorphin 6  0   *Hemoglobins *Peptide Fragments Opioid Peptides. FEBS Lett 1991;287(1-2):39
cyclo(tyrosyl-ornithyl-phenylalanyl-aspartamide)  96382-72-8   *Peptides, Cyclic *Opioid Peptides. Biopolymers 1987;26(8):1431
dermorphin  77614-16-5 Dermorphin  *Opioid Peptides.
Pharma Action Analgesics, Opioid 		Int J Pept Protein Res 1981;17(2):263
exorphins  69989-30-6   *Peptides Glutens Opioid Peptides. J Biol Chem 254(7):2446;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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