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Antineoplastic Agents, Hormonal

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Definition: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)  consider also NEOPLASMS, HORMONE-DEPENDENT /drug ther    Other names Hormonal Drugs, Antineoplastic; Drugs, Antineoplastic Hormonal; Agents, Antineoplastic Hormonal; Hormonal Antineoplastics; Hormonal Antineoplastic Drugs; Hormonal Agents, Antineoplastic; Antineoplastics, Hormonal; Antineoplastic Hormonal Drugs; Antineoplastic Hormonal Agents; Antineoplastic Drugs, Hormonal; Hormonal Antineoplastic Agents
Substances having this pharmacologic action: dienogest; anastrozole; fosfestrol; Chlorotrianisene; Prednisolone; Prednisone; Nafoxidine; Tamoxifen; Testolactone; Leuprolide; Medroxyprogesterone Acetate; Goserelin; Toremifene; Fadrozole; Triptorelin Pamoate; Octreotide; Megestrol Acetate; Medrogestone; Megestrol; Methylprednisolone Hemisuccinate; Methyltestosterone; Flutamide; Hexestrol; Mitotane; Estramustine; Aminoglutethimide; Dexamethasone; tibolone; fulvestrant; liarozole; leukoregulin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
9-fluoro-16alpha-methyl-11,17-dihydroxy-3-oxo-1,4-androstadiene-17beta-carboxylic acid  0   *Androstadienes Antineoplastic Agents, Hormonal. Ai Zheng. 2009 Mar;28(3):255-61
luprolide acetate gel depot  0   *Leuprolide Delayed-Action Preparations Antineoplastic Agents, Hormonal. Urology. 2003 Feb;61(2 Suppl 1):25-31ELIGARD
nomegestrol  58691-88-6 19-Norpregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl  Megestrol/*analogs & derivatives Antineoplastic Agents, Hormonal Progesterone Congeners. Rev Fr Gynecol Obstet 1985;80(10):757
nomegestrol acetate  58652-20-3   *Megestrol *Norpregnadienes Antineoplastic Agents, Hormonal Progesterone Congeners. Arzneimittelforsch 1983;33(5):710

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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