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Macrolides

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Definition: A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.     
Examples Amphotericin B; Antimycin A; Brefeldin A; Bryostatins; Candicidin; Epothilones; Erythromycin; Filipin; Ivermectin; Josamycin; Leucomycins; Lucensomycin; Maytansine; Mepartricin; Miocamycin; Natamycin; Nystatin; Oleandomycin; Oligomycins; Sirolimus; Tacrolimus; Tylosin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
salarin C  0   *Macrolides Coloring Agents. Invest New Drugs. 2012 Feb;30(1):98-104.
ethylene dodecanedioate  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S212-8
omega-6-hexadecenlactone  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S207-11
oxacyclohexadecane-2,13-dione  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S202-6
omega-pentadecalactone  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S193-201
oxacycloheptadec-10-ene-2-one  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S189-92
hexadecanolide  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S183-8
12-oxahexadecanolide  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S168-73
11-oxahexadecanolide  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S163-7
10-oxahexadecanolide  0   *Macrolides. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S158-62
lyngbouilloside aglycon  0   *Lactones *Macrolides. Org Lett. 2012 Jan 6;14(1):314-7
pamamycin-649B  0   *Macrolides. Chemistry. 2011 Nov 18;17(47):13334-40
CP2-disorazole C1  0   *Oxazoles *Macrolides. Org Lett. 2011 Aug 5;13(15):4088-91
amphidinolactone A  0   *Macrolides. Org Biomol Chem. 2011 Aug 21;9(16):5630-2
chaxalactin C  0   *Macrolides. J Nat Prod. 2011 Sep 23;74(9):1965-71
chaxalactin B  0   *Macrolides. J Nat Prod. 2011 Sep 23;74(9):1965-71
chaxalactin A  0   *Macrolides. J Nat Prod. 2011 Sep 23;74(9):1965-71
des-methyl, des-amino pateamine A  0   *Epoxy Compounds *Thiazoles *Macrolides. Mol Cancer Ther. 2009 May;8(5):1250-60
macrolactin W  0   *Glycosides *Macrolides. Bioorg Med Chem Lett 2011 Jun 15;21(12):3832-5
3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione  0   *Macrolides. Mar Drugs 2011;9(5):844-51
(8R,9S)-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A  0   Erythromycin/*analogs & derivatives Macrolides. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3373-6
simplextone B  0   *Macrolides. Org Lett. 2011 Jun 17;13(12):3154-7
simplextone A  0   *Macrolides. Org Lett. 2011 Jun 17;13(12):3154-7
ent-pochonin J  0   *Macrolides. J Org Chem. 2011 May 20;76(10):3898-908
kabiramide K  0   *Oxazoles *Macrolides. J Nat Prod. 2011 May 27;74(5):1288-92
kabiramide J  0   *Oxazoles *Macrolides. J Nat Prod. 2011 May 27;74(5):1288-92
archazolid A-15-O-beta-D-glucopyranoside  0   *Glucosides *Thiazoles *Macrolides. J Nat Prod. 2011 May 27;74(5):1100-5
bafilomycin K  0   *Macrolides. J Antibiot (Tokyo) 2011 May;64(5):391-3
7-O-succinyl macrolactin A  0   *Macrolides. Arch Pharm Res 2011 Jan;34(1):147-52
azalomycin F5a  0   *Macrolides. Magn Reson Chem. 2011 Jan;49(1):30-7
azalomycin F4a  0   *Macrolides. Magn Reson Chem. 2011 Jan;49(1):30-7
azalomycin F3a  0   *Macrolides. Magn Reson Chem. 2011 Jan;49(1):30-7
12-hydroxy-4-methyldecahydro-1H-benzo(d)oxecine-2,9-dione  0   *Macrolides. Bioorg Med Chem Lett 2011 Apr 15;21(8):2451-9
leiodermatolide  0   *Macrolides. Angew Chem Int Ed Engl 2011 Mar 28;50(14):3219-23
elansolid B1  0   *Macrolides. Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3882-7
elansolid B3  0   *Macrolides. Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3882-7
elansolid B2  0   *Macrolides. Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3882-7
maklamicin  0   *Macrolides. J Nat Prod. 2011 Apr 25;74(4):670-4
stambomycin D  0   *Macrolides. Proc Natl Acad Sci U S A 2011 Apr 12;108(15):6258-63
stambomycin C  0   *Macrolides. Proc Natl Acad Sci U S A 2011 Apr 12;108(15):6258-63
stambomycin B  0   *Macrolides. Proc Natl Acad Sci U S A 2011 Apr 12;108(15):6258-63
stambomycin A  0   *Macrolides. Proc Natl Acad Sci U S A 2011 Apr 12;108(15):6258-63
de-O-methyllasiodiplodin  0   *Macrolides Lipase/antagonists & inhibitors Receptors, Mineralocorticoid/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Aug 15;16(16):4205-8
elansolid A  0   *Macrolides. Angew Chem Int Ed Engl. 2011 Jan 10;50(2):532-6
E 7107  0   *Epoxy Compounds *Macrolides. Genes Dev 2011 Mar 1;25(5):440-4
latrunculol A  0   *Macrolides *Thiazolidines. Anal Bioanal chem 2010 Mar;396(5):1741-4
roritoxin E  0   *Trichothecenes *Macrolides. Planta Med. 2010 Jul;76(10):1004-6
verticilactam  0   *Lactams *Macrolides. Org Lett. 2010 Oct 15;12(20):4564-7
amphidinolide C2  0   *Macrolides. Org Lett. 2010 Nov 5;12(21):4976-9
epoxyphomalin E  0   *Macrolides. J Nat Prod. 2010 Dec 27;73(12);2053-6
epoxyphomalin D  0   *Macrolides. J Nat Prod. 2010 Dec 27;73(12);2053-6
epoxyphomalin C  0   *Macrolides. J Nat Prod. 2010 Dec 27;73(12);2053-6
lytophilippine A  0   *Macrolides. Org Lett. 2010 Nov 19;12(22);5258-61
plasmocin  0   *Macrolides. PLoS One 2010;5(3):e9900
enigmazole A  0   *Organophosphorus Compounds *Oxazoles *Macrolides. J Am Chem Soc. 2010 Aug 4;132(30):10278-85
carolacton  0   *Macrolides. BMC Microbiol 2010;10:199
JBIR-100  0   *Macrolides. J Antibiot (Tokyo). 2010 Oct;63(10):627-9
alchivemycin A  0   *Macrolides Micrococcus luteus/drug effects. Org Lett. 2010 Aug 6;12(15):3402-5
gamithromycin  0 1-Oxa-7-azacyclopentadecan-15-one,13-((2,6-dideoy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy 3,5,8,10,12,14-hexamethyl-7-propyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-, ((2R*, 3S*,4R*,5S*  *Macrolides.
Pharma Action Anti-Bacterial Agents 		J Vet Pharmacol ther 2010 Jun 1;33(1):227-37
6-epi-16-desmethyl-25,26-dihydrodictyostatin  0   *Macrolides. J Am Chem Soc. 2010 Jul 7;132(26):9175-87
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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