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Nitric Oxide Synthase

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Definition: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.  general; prefer specifics   
Examples Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III 		Other names Synthase, Nitric Oxide; Oxide Synthase, Nitric; Nitric Oxide Synthetase; Nitric-Oxide Synthetase; Nitric-Oxide Synthase; NO Synthase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NOA1 protein, Arabidopsis  EC 1.14.13.39   *Nitric Oxide Synthase *Arabidopsis Proteins. Science 2003 Oct 3;302(5642):100-3
N-((3-(aminomethyl)phenyl)methyl)ethanimidamide  0   *Imines Nitric Oxide Synthase/antagonists & inhibitors. Microcirculation. 2004 Sep;11(6):503-15
Nostrin protein, mouse  0   *DNA-Binding Proteins *Adaptor Proteins, Signal Transducing Nitric Oxide Synthase. Biochem Biophys Res Commun 2005 Jan 21;326(3):594-9
1-cyclopropanecarbonyl-3-(2-amino-5-methoxyphenyl)-4,5-dihydro-1H-pyrazole  0   *Aniline Compounds *Pyrazoles Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 2004 Nov 4;47(23):5641-50
1-cyclopropanecarbonyl-3-(2-amino-5-chlorophenyl)-4,5-dihydro-1H-pyrazole  0   *Aniline Compounds *Pyrazoles Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 2004 Nov 4;47(23):5641-50
AR C102222AA  0   *Quinazolines Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 2003 Mar 13;46(6):913-6
N-(4-(2-((3-chlorophenylmethyl)amino)ethyl)phenyl)-2-thiophenecarboxamide  0   *Amidines *Thiophenes Nitric Oxide Synthase/antagonists & inhibitors. Proc Natl Acad Sci U S A 2004 Apr 20; 101(16):5892-7
6-(4-(N,N-dimethylaminoethoxy)-5,6,7,8-tetrahydronaphthalen-1-yl)pyridin-2-ylamine  0   *Aminopyridines *Tetrahydronaphthalenes Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 2004 Mar 11;47(6):1575-86
5-fluoro-N6-(iminoethyl)lysine  0   Lysine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 2004 Feb 12;47(4):900-6
4-N-nitroarginyl-4-aminoprolinamide  0   *Dipeptides Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 2004 Jan 29;47(3):703-10
N-(6-bromo-7-hydroxycoumarin-4-yl)methoxycarbonyl-N-(3-(aminomethyl)benzyl)acetamide  0   *Amidines *Coumarins Nitric Oxide Synthase/antagonists & inhibitors. Bioorg Med Chem 2002 Jun;10(6):1919-27
NOSTRIN protein, human  0   *Intracellular Signaling Peptides and Proteins Nitric Oxide Synthase. Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17167-72
PPA 250  0   *Imidazoles *Pyridines Nitric Oxide Synthase/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Oct;303(1):52-7
N-(4-nitrophenacyl)-2-methylimidazole  0   *Imidazoles *Nitrobenzenes Nitric Oxide Synthase/antagonists & inhibitors. Blood 2001 May 15;97(10):32-8
N-(4-nitrophenacyl)imidazole  0   *Imidazoles *Nitrobenzenes Nitric Oxide Synthase/antagonists & inhibitors. Nitric Oxide 2001;5(1):32-8
aminoethyl-isothiourea  0   Thiourea/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. Crit Care Med 2000 Aug;28(8):2697-706
kikkanol D  0   *Sesquiterpenes Nitric Oxide Synthase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2000 May;48(5):651-6
kikkanol F  0   *Sesquiterpenes Nitric Oxide Synthase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2000 May;48(5):651-6
kikkanol E  0   *Sesquiterpenes Nitric Oxide Synthase/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 2000 May;48(5):651-6
GW 274150  0   *Sulfides Nitric Oxide Synthase/antagonists & inhibitors. Bioorg Med Chem Lett 2000 Mar 20;10(6):597-600
GW 273629  0   *Sulfones Nitric Oxide Synthase/antagonists & inhibitors. Bioorg Med Chem Lett 2000 Mar 20;10(6):597-600
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane  0   *Amidines Heterocyclic Compounds, 2-Ring Nitric Oxide Synthase/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Apr 13;270(2):663-7
cyclolinteinone  159934-16-4   *Cyclohexanones 4-Butyrolactone/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. Biochem J 2000 Mar 15;346( Pt 3):793-98
nepalolide A  0   *Anthracenes Nitric Oxide Synthase/antagonists & inhibitors. Br J Pharmacol 1999 Sep;128(2):345-56
fraxiden  0   *Coumarins Nitric Oxide Synthase/antagonists & inhibitors. Planta Med 1999 oct;65(7):656-8
alisol B monoacetate  0   *Cholestenones Nitric Oxide Synthase/antagonists & inhibitors. Biol Pharm Bull 1999 Oct;22(10):1147-9
N(delta)-(4,5-dihydrothiazol-2-yl)ornithine  0   *Thiazoles Ornithine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. Bioorg Med Chem 1999 Sep;7(9):1787-96
4,8-dimethoxy-1-vinylcarboline  0   *Carbolines Nitric Oxide Synthase/antagonists & inhibitors. Arch Pharm Res 1999 Aug;22(4):410-3
4-methoxy-1-vinylcarboline  0   *Carbolines Nitric Oxide Synthase/antagonists & inhibitors. Arch Pharm Res 1999 Aug;22(4):410-13
BN 80933  0   *Pyrazines *Thiophenes Nitric Oxide Synthase. Cell Mol Life Sci 1999 Jul;55(8-9):1029-35
N(omega)-nitroarginine-2,4-diaminobutryic amide  0   Nitroarginine Nitric Oxide Synthase. J Med Chem 1999 Aug 12;42(16):3147-53
S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea  0   Thiourea/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. Carcinogenesis 1999 Apr;20(4):641-4
yomogin  0   *Sesquiterpenes, Eudesmane Nitric Oxide Synthase/antagonists & inhibitors. Arch Pharm Res 1998 Aug;21(4):481-4
HMN 1180  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Pharmacol Exp Ther 1998 Dec;287(3):1063-7
4-methyl-5-pentylpyrrolidin-2-imine  0   *Imines *Pyrrolidines Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1998 Sep 10;41(19):3675-83
alpha-fluoro-N-(3-(amimomethyl)phenyl)acetamidine  0   *Amidines Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1998 Jul 16;41(15):2858-71
N-(3-(aminomethyl)phenyl)-2-furanylamidine  0   *Amidines *Furans Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1998 Jul 16;41(15):2858-71
7-(2-ethylbutyl)hexahydro-1H-azepin-2-imine  0   *Azepines *Imines Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1998 Apr 23;41(9):1361-6
hexahydro-7-propyl-1H-azepin-2-imine  0   *Azepines *Imines Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1998 Apr 23;41(9):1361-6
hexahydro-3-(2-propenyl)-1H-azepin-2-imine  0   *Azepines *Imines Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1998 Apr 23;41(9):1361-6
N(5)-(1-imino-3-butenyl)ornithine  0   Ornithine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Biol Chem 1998 Apr 10;273(15):8882-9
N-(5-amino-6,7-dihydroxyheptyl)ethanimidamide  0   *Fatty Alcohols *Imines Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1998 Mar 12;41(6):775-7
N(omega)-propylarginine  0   Arginine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1997 Nov 21;40(24):3869-70
N(omega)-hydroxy-N(omega)-propargylarginine  0   Arginine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. Bioorg Med Chem 1997 Aug;5(8):1601-8
N(omega)-propargylarginine  0   Arginine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. Bioorg Med Chem 1997 Aug;5(8):1601-8
pyrazole-1-carboxamidine  0   *Pyrazoles Nitric Oxide Synthase/antagonists & inhibitors. Biochem Pharmacol 1997 Aug 1;54(3):409-17
4-amino-tetrahydrobiopterin  0   Biopterin/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. Biochemistry 1997 Jul 8;36(27):8422-7
3-bromo-7-nitroindazole  0   *Indazoles Nitric Oxide Synthase/antagonists & inhibitors. Eur J Pharmacol 1997 Apr 11;324(1):11-20
S-ethyl N-(4-(trifluoromethyl)phenyl)isothiourea  163490-40-2   Thiourea/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1901-5
N-(3-(aminomethyl)benzyl)acetamidine  0   *Amidines *Benzylamines Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Biol Chem 1997 Feb 21;272(8):4959-63
6-nitroindazole  7597-18-4   *Indazoles Nitric Oxide Synthase/antagonists & inhibitors. Pain 1996 Aug;66(2-3):313-9
ARL 17477  0   *Amidines Nitric Oxide Synthase/antagonists & inhibitors. J Cereb Blood Flow Metab 1996 Jul;16(4):599-604
2-mercaptoethylguanidine  1190-74-5   *Guanidines Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
1-(2-trifluoromethylphenyl)imidazole  25371-96-4   *Imidazoles Nitric Oxide Synthase/antagonists & inhibitors. Br J Pharmacol 1995 Nov;116(5):2349-50
2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine  0   *Thiazines Nitric Oxide Synthase/antagonists & inhibitors. Mol Pharmacol 1995 Apr;47(4):831-4
N(G)-monomethylarginine acetate  0   Arginine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Pharmacol Exp Ther 1995 Mar;272(3):1011-5
N(6)-(1-iminoethyl)lysine  0   Lysine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Med Chem 1994 Nov 11;37(23):3886-8
S-ethylthiocitrulline  0   Citrulline/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Biol Chem 1994 Oct 28;269(43):26677-83
carboxyebselen  153871-75-1   *Organoselenium Compounds Nitric Oxide Synthase/antagonists & inhibitors. J Physiol Pharmacol 1994 Mar;45(1):55-67
S-methylthiocitrulline  156719-41-4 L-Ornithine, N5-(imino(methylthio)methyl)  Citrulline/*analogs & derivatives Thiourea/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Med Chem 1994 Apr 1;37(7):885-7
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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