Proto-Oncogene Proteins c-kit (definition)

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Proto-Oncogene Proteins c-kit

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Definition: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

See Also Piebaldism

Other names p145c kit; p145 c kit; kit Proto Oncogene Protein; c-kit, p145; c-kit, Proto-Oncogene Proteins; c-kit, Proto-Oncogene Protein; c kit Receptor; c kit Protein; Proto-Oncogene Protein, kit; Proto Oncogene Proteins c kit; Proto Oncogene Protein kit; Proto Oncogene Protein c kit; p145c-kit; p145 c-kit; SCF Receptor; Proto-Oncogene Protein kit; Proto-Oncogene Protein c-kit; CD117 Antigen; p145(c-kit); kit Proto-Oncogene Protein

Substance	CAS Registry & name	Categories	Source
N3-(4-(4-morpholinocyclohexyl)phenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine	0	Morpholines Triazoles Proto-Oncogene Proteins c-kit/antagonists & inhibitors.	J Med Chem. 2011 Oct 27;54(20):7184-92.
4-t-butylphenyl-N-(4-imidazol-1-ylphenyl)sulfonamide	0	Imidazoles Sulfonamides Proto-Oncogene Proteins c-kit.	Biochem Pharmacol 2007 Sep 1;74(5):780-6
2B8-BM monoclonal antibody	0	*Antibodies, Monoclonal Proto-Oncogene Proteins c-kit.	J Immunol Methods. 2007 Apr 10;321(1-2):70-9
motesanib diphosphate	857876-30-3	Indoles Niacinamide/analogs & derivatives Proto-Oncogene Proteins c-kit.	Clin Colorectal Cancer 2006 Nov;6 Suppl 1:S30-4
xkrk1 protein, Xenopus	EC 2.7.11.-	Proto-Oncogene Proteins c-kit Xenopus Proteins.	Dev Biol 2001 Nov 15;239(2):270-80

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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