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Antigens, CD40

More information in Books or onNLM PubMed
Definition: A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.     
See Also CD40 Ligand
Other names Receptor, TNFRSF5; Antigen, CDw40; Antigen, CD40; TNFRSF5 Receptor; CDw40 Antigen; CD40 Antigen; Tumor Necrosis Factor Receptor Superfamily, Member; CD40 Antigens
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CD40LIg fusion protein  0   *Recombinant Fusion Proteins Immunoglobulin Variable Region Antigens, CD40. Transplant Proc 2007 Dec;39(10):3436-7
CD40Ig protein, recombinant  0   *Recombinant Fusion Proteins Immunoglobulins Antigens, CD40. Mol Ther 2004 Oct;10(4):688-96
TRAF3 protein, human  0   *TNF Receptor-Associated Factor 3 Antigens, CD40. J Biol Chem 1994 Dec 2;269(48):30069-72

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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