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Platelet Glycoprotein GPIIb-IIIa Complex

More information in Books or onNLM PubMed
Definition: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.     
See Also Thrombasthenia 		Other names beta-3, Integrin alpha-IIb; alphaIIbbeta3, Integrin; Receptors, GPIIb-IIIa; Platelet Glycoprotein GPIIb IIIa Complex; Integrin alpha IIb beta 3; Glycoproteins IIb IIIa; GPIIb IIIa Receptors; Integrin alpha-IIb beta-3; Glycoproteins IIb-IIIa; Integrin alphaIIbbeta3; GPIIb-IIIa Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tablysin-15, Tabanus yao  0   *Salivary Proteins and Peptides *Insect Proteins Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors Integrin alphaVbeta3/antagonists & inhibitors.
EP 224283  0   *Oligosaccharides Biotin/*analogs & derivatives Factor XI/antagonists & inhibitors Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Pharmacol Exp Ther 2011 Aug;338(2):412-20
batifiban  0   *Peptides, Cyclic Platelet Aggregation Inhibitors Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):12-8
CP-4715  0   *Piperidines *Pyrimidines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors Integrin alphaVbeta3/antagonists & inhibitors. Cardiovasc Res 2005 Jun 1;66(3):552-61
3-((2-(4-(N-hydroxycarbamimidoyl)phenyl)-1-oxo-2,8-diazaspiro(4,5)decane-8-carbonyl)amino)propionic acid ethyl ester  0   *Hydroxylamines *Spiro Compounds Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):2037-61
CRL 42796  0   *Dipeptides *Sulfonamides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Br J Pharmacol 2002 Jul;136(6):927-37
TAK 024  0   *Guanidines *Piperazines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 2001 Jul 19;44(15):2438-50
ethyl 3-(2-(4-(4-aminoiminomethylphenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetylamino)-3-phenylpropionate  0   *Imidazoles *Propionates Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 2001 Apr 12;44(8):1158-76
RGD891  0   *Oligopeptides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Clin Pharmacol 2000 Nov;40(11):1245-56
2-benzenesulfonylamino-3-(4-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)benzoylamino)propionic acid  0   *Naphthyridines *Sulfonamides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 2000 Oct 5;43(20):3736-45
lotrafiban  171049-14-2   *Benzodiazepines *Piperidines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Circulation 2000 Aug 15;102(7):728-35
DMP 444  0   *Oligopeptides *Organotechnetium Compounds Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Eur J Nucl Med 2000 Apr;27(4):392-9
TS 943  0   *Amidines *Thiazoles Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Clin Pharmacol ther 2000 May;67(5):489-97
6-((4-amidinobenzoyl)amino)tetralone-2-acetic acid  0   *Acetic Acids *Amidines *Tetralones Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Bioorg Med Chem Lett 2000 Feb 21;10(4):385-9
klerval  0   *Oligopeptides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Int J Pharm 1999 Nov 10;190(1):1-11
2-(N-(3-pyridylsulfonyl)amino)-3-((2-carbonyl-5-(2-(piperidin-4-yl)ethyl)thieno(2,3-b)thiopheneyl)amino)propionic acid  0   *Sulfonamides *Thiophenes Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 1999 Jul 1;42(13):2409-21
roxifiban  176022-59-6   *Amidines *Isoxazoles Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Pharm Sci 1999 Mar;88(3):297-301
3-(4-(aminoiminomethyl)phenyl)-5-((((2-carboxy-2-((3-methylphenyl)sulfonamido)ethyl)amino)carbonyl)methyl)-2-methylisoxazole  0   *Isoxazoles *Sulfonamides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Jan 4;9(1):55-8
ME 3277  0   *Amides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Ann Plast Surg 1998 Oct;41(4):452-3
DMP 755  0   *Amino Acids *Isoxazoles Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Thromb Res 1998 Nov 1;92(3):115-24
MS 180  0   *Acetic Acids *Morpholines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):4036-52
DMP 802  0   *Isoxazoles *Sulfonamides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Cardiovasc Pharmacol 1998 Aug;32(2):169-76
ethyl N-(3-(2-fluoro-4-(thiazolidin-3-yl(imino)methyl)benzoyl)amino-2,2-dimethylpentanoyl)piperidine-4-acetate  0   *Benzamidines *Piperidines *Thiazolidines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 1998 Jun 18;41(13):2345-60
SM 20302  0   *Benzene Derivatives Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Arterioscler Thromb Vasc Biol 1998 Jun;18(6):954-60
XR 300  0   *Isoxazoles Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Cardiovasc Pharmacol 1998 Mar;31(3):441-8
Ro 48-3656  0   *Heterocyclic Compounds *Oximes Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Chromatogr B Biomed Sci Appl 1997 19;704(1-2):231-42
orotyl-seryl-arginyl-glycyl-aspartyl-tryptophane  0   *Oligopeptides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Thromb Res 1997 Oct 1;88(1):27-40
L 767679  0   *Piperazines beta-Alanine/*analogs & derivatives Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Drug Metab Dispos 1997 Aug;25(8):979-84
lefradafiban  149503-79-7   *Pyrrolidines *Biphenyl Compounds Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Circulation 1997 Aug 19;96(4):1130-8
fradafiban  148396-36-5   *Biphenyl Compounds *Pyrrolidines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Circulation 1997 Aug 19;96(4):1130-8
XU 063  0   *Isoxazoles Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Thromb Res 1997 May 1;86(3):221-32
platelet glycoprotein (GP)IIIa 49-66  0   *Peptide Fragments *Platelet Glycoprotein GPIIb-IIIa Complex. Proc Natl Acad Sci U S A 1997 Jul 8;94(14):7589-94
SR 121566  0   *Benzylamines *Piperidines *Thiazoles Platelet Aggregation Inhibitors Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Blood Coagul Fibrinolysis 1997 Apr;8(3):206-7
L 742998  0   *Pyridines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Drug Metab Dispos 1996 Nov;24(11):1263-71
XV 459  0   *Amino Acids *Isoxazoles Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Coron Artery Dis 1996 Oct;7(10):767-74
DMP 754  0   *Amino Acids *Isoxazoles Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Coron Artery Dis 1996 Oct;7(10):767-74
sibrafiban  0   *Oximes *Piperidines Prodrugs Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors.
Pharma Action Platelet Aggregation Inhibitors 		J Med Chem 1996 Aug 2;39(16):3139-47
Ro 44-3888  0   *Amidines *Piperidines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Med Chem 1996 Aug 2;39(16):3139-47
SDZ GPI 562  0   *Benzylamines Platelet Aggregation Inhibitors Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Clin Invest. 1998 Oct 1;102(7):1301-10; Transplant Proc 1996 Apr;28(2):703
TAK 029  0   *Guanidines *Pyrazines Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Pharmacol Exp Ther 1996 Apr;277(1):502-10
eptifibatide  0   *Peptides Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors.
Pharma Action Platelet Aggregation Inhibitors 		Am J Med 1994 Mar;96(3):300INTEGRILIN
abciximab  143653-53-6   *Antibodies, Monoclonal *Immunoglobulin Fab Fragments Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors.
Pharma Action Anticoagulants ; Platelet Aggregation Inhibitors 		Circulation 1994 Feb;89(2):596-603REOPRO
tirofiban  144494-65-5   Tyrosine/*analogs & derivatives Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors.
Pharma Action Fibrinolytic Agents ; Platelet Aggregation Inhibitors 		J Med Chem 1992 Nov 27;35(24):4640-2AGGRASTAT

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