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Helix-Turn-Helix Motifs

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Definition: The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)  do not confuse with HELIX-LOOP-HELIX MOTIFS    Other names Motifs, Helix Turn Helix; Motifs, HTH; Motif, Helix-Turn-Helix; Motif, HTH; Helix-Turn-Helix Motif; Helix Turn Helix Motifs; HTH Motif; Motifs, Helix-Turn-Helix; HTH Motifs
 
SubstanceCAS Registry & nameCategoriesSource
BOLA1 protein, human  0   *Proteins Helix-Turn-Helix Motifs. Mol Cell Biochem 2008 Oct;317(1-2):61-8
MBR-1 protein, C elegans  0   *Transcription Factors *Caenorhabditis elegans Proteins Helix-Turn-Helix Motifs. Curr Biol 2005 Sep 6;15(17):1554-9
IRF6 protein, zebrafish  0   *Zebrafish Proteins *Interferon Regulatory Factors DNA-Binding Proteins Helix-Turn-Helix Motifs. Gene Expr Patterns 2005 Jun;5(5):629-38
FOXD3 protein, human  0   *Forkhead Transcription Factors Trans-Activators Helix-Turn-Helix Motifs. J Invest Dermatol 2005 Aug;125(2):388-91
LrpA protein, bacteria  0   *Bacterial Proteins *Leucine-Responsive Regulatory Protein Helix-Turn-Helix Motifs.
ZntR protein, E coli  0   *Transcription Factors *Escherichia coli Proteins Helix-Turn-Helix Motifs.
Foxd3 protein, rat  0   *Repressor Proteins *Forkhead Transcription Factors Helix-Turn-Helix Motifs.
PDRG1 protein, human  0   *DNA-Binding Proteins Helix-Turn-Helix Motifs. Oncogene 2003 Oct 16;22(46);7247-57
SarU protein, Staphylococcus aureus  0   *DNA-Binding Proteins Helix-Turn-Helix Motifs. Infect Immun 2003 Jan;71(1):343-53
MtaN protein, Bacillus subtilis  0   *Bacterial Proteins *Trans-Activators Helix-Turn-Helix Motifs. J Biol Chem 2001 Dec 14;276(50):47178-84
MrpJ protein, Proteus mirabilis  0   *Bacterial Proteins *Repressor Proteins Helix-Turn-Helix Motifs. Infect Immun 1999 Jun;67(6):2822-33
IdiB protein, Synechococcus  0   *Bacterial Proteins *Transcription Factors Helix-Turn-Helix Motifs. Microbiology 1999 Jun;145( Pt 6):1473-84
PsrA protein, Pseudomonas  0   *Bacterial Proteins *DNA-Binding Proteins *Transcription Factors Helix-Turn-Helix Motifs. J Bacteriol 2001 Jun;183(12):3712-20
PikD protein, Streptomyces venezuelae  0   *Bacterial Proteins *DNA-Binding Proteins *Transcription Factors Helix-Turn-Helix Motifs. J Bacteriol 2001 Jun;183(11):3468-75
Ptr2 protein, Methanococcus jannaschii  0   *DNA-Binding Proteins *Archaeal Proteins Helix-Turn-Helix Motifs. EMBO J 2001 Jan 15;20(1-2):146-56
Ptr1 protein, Methanococcus jannaschii  0   *DNA-Binding Proteins *Archaeal Proteins Helix-Turn-Helix Motifs. EMBO J 2001 Jan 15;20(1-2):146-56
MatR protein, Rhizobium leguminosarum  0   *Bacterial Proteins *Transcription Factors Helix-Turn-Helix Motifs. Eur J Biochem 2000 Dec;267(24):7224-29
LrpA protein, Pyrococcus furiosus  0   *Archaeal Proteins *Leucine-Responsive Regulatory Protein Helix-Turn-Helix Motifs. J Biol Chem 2000 Dec 8;275(49):38160-9
BldM protein, Streptomyces coelicolor  0   *Bacterial Proteins *DNA-Binding Proteins Helix-Turn-Helix Motifs. Mol Microbiol 2000 Jun;36(6):1265-78
devH protein, Nostoc  0   *Bacterial Proteins *DNA-Binding Proteins Helix-Turn-Helix Motifs. J Bacteriol 2000 Jun;182(12):3572-81
PhlF protein, Pseudomonas fluorescens  0   *Bacterial Proteins *Repressor Proteins Helix-Turn-Helix Motifs. Microbiology 2000 Feb;146( Pt 2):537-46
chnR protein, Acinetobacter  0   *Bacterial Proteins *Trans-Activators Helix-Turn-Helix Motifs. Appl Environ Microbiol 1999 Nov;65(11):5158-62
SkgA protein, Caulobacter crescentus  0   *Bacterial Proteins *Trans-Activators Bacterial Proteins Helix-Turn-Helix Motifs. J Bacteriol 1999 Oct;181(19):6152-9
HPr-response regulator, Clostridium acetobutylicum  0   *Bacterial Proteins *DNA-Binding Proteins *Transcription Factors Helix-Turn-Helix Motifs. Microbiology 1999 May;145( Pt 5):987-9
LicR protein, Bacillus subtilis  0   *Bacterial Proteins *Trans-Activators Helix-Turn-Helix Motifs. J Bacteriol 1997 Jan;179(2):496-506
ClyR protein, Leuconostoc mesenteroides  0   *Bacterial Proteins Helix-Turn-Helix Motifs. J Bacteriol 1999 Jul;181(14):4411-6
AphB protein, Vibrio cholerae  0   *Bacterial Proteins *Trans-Activators Helix-Turn-Helix Motifs. J Bacteriol 1999 Jul;181(14):4250-6
UreR protein, bacteria  0   *Bacterial Proteins *Trans-Activators Helix-Turn-Helix Motifs. J Bacteriol 1993 Jun;175(11):3459-67
DnrE protein, Pseudomonas stutzeri  0   *Bacterial Proteins *Transcription Factors Bacterial Proteins Helix-Turn-Helix Motifs. Mol Microbiol 1999 Mar;31(6):1681-94
ZntR protein, bacteria  0   *Bacterial Proteins *Transcription Factors Helix-Turn-Helix Motifs. Mol Microbiol 1999 Feb;31(3):893-902
PrhJ protein, Ralstonia solanacearum  0   *Bacterial Proteins *Transcription Factors Signal Transduction Helix-Turn-Helix Motifs. Mol Microbiol 1999 Jan;31(1):237-51
CtsR protein, bacteria  0   *Bacterial Proteins *Repressor Proteins Helix-Turn-Helix Motifs. Mol Microbiol 1999 Jan;31(1):117-31
Lrs14 protein, Sulfolobus solfataricus  0   *DNA-Binding Proteins *Transcription Factors *Archaeal Proteins Helix-Turn-Helix Motifs. J Bacteriol 1999 Mar;181(5):1474-80
StgU protein, Streptomyces lipmanii  0   *Bacterial Proteins Helix-Turn-Helix Motifs. Mol Gen Genet 1998 Sep;259(5):475-83
StgR protein, Streptomyces alboniger  0   *Bacterial Proteins *Repressor Proteins Helix-Turn-Helix Motifs. Mol Gen Genet 1998 Sep;259(5):475-83
BldB protein, Streptomyces coelicolor  0   *Bacterial Proteins Helix-Turn-Helix Motifs. J Bacteriol 1998 Mar;180(6):1556-62
BldD protein, Streptomyces coelicolor  0   *Bacterial Proteins *DNA-Binding Proteins *Transcription Factors Helix-Turn-Helix Motifs. J Bacteriol 1998 Mar;180(6):1549-55
Foxd3 protein, mouse  0   *Repressor Proteins *Forkhead Transcription Factors Helix-Turn-Helix Motifs. J Biol Chem 1996 Sep 20;271(38):23126-33
Roi protein, Bacteriophage HK022  0   *DNA-Binding Proteins *Viral Proteins Helix-Turn-Helix Motifs. J Bacteriol 1996 Jul;178(14):4077-83
stonewall protein, Drosophila  0   *DNA-Binding Proteins *Transcription Factors *Drosophila Proteins Helix-Turn-Helix Motifs. Development 1996 Mar;122(3):937-50

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