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Telomerase

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Definition: An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.     
See Also Telomere Homeostasis 		Other names Transcriptase, Telomerase Reverse; Subunit, Telomerase Catalytic; Reverse Transcriptase, Telomerase; Catalytic Subunit, Telomerase; Telomerase Reverse Transcriptase Catalytic Subunit; Telomerase Reverse Transcriptase; Telomerase Catalytic Subunit
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
EST1 protein, S pombe  EC 2.7.7.49   *Telomerase *Schizosaccharomyces pombe Proteins Protein Subunits. Nat Struct Mol Biol. 2011 Dec;18(12):1408-13
2,2'-(1,3-phenylene)-bis-(5-(4-(2-hydroxyethyl)-1-piperazinyl)-1H-benzimidazole)  0   *Benzimidazoles *Piperazines Telomerase/antagonists & inhibitors. Bioconjug Chem 2010 Jul 21;21(7):1148-59
2,2'-(1,4-phenylene)-bis-(5-(4-(2-hydroxyethyl)-1-piperazinyl)-1H-benzimidazole)  0   *Benzimidazoles *Piperazines Telomerase/antagonists & inhibitors. Bioconjug Chem 2010 Jul 21;21(7):1148-59
5'-oleic-TAGGGTTAGACAA-3'  0   *Oligonucleotides Telomerase/antagonists & inhibitors. Breast Cancer Res Treat 20-09 Nov;118(1):21-32
telomerase Cajal body protein 1, human  EC 2.7.7.49   *Telomerase. Science. 2009 Jan 30;323(5914):644-8
TERT protein, Arabidopsis  EC 2.7.7.49   *Telomerase *Arabidopsis Proteins Protein Subunits. FEBS Lett 1999 Sep 3;457(3):465-9
hTERT mp30-38 peptide  EC 2.7.7.-   *Telomerase Peptide Fragments. Cancer Immunol Immunother 2007 Nov;56(11):1755-63
telomerase reverse transcriptase p572Y, human  EC 2.7.7.49   *Telomerase. J Clin Oncol 2007 Jul 1;25(19):2727-34
N'-(10H-indolo(3,2-b)quinolin-11-yl)-N,N-dimethylpropane-1,3-diamine  0   *Diamines *Quinolines Telomerase/antagonists & inhibitors. Leukemia 2007 Jun;21(6):1300-2
GV1001 peptide  EC 2.7.7.-   *Peptide Fragments *Telomerase. Cancer Immunol Immunother 2006 Dec;55(12):1553-64
SMG6 protein, human  EC 2.7.7.49   *Telomerase Protein Subunits. Curr Biol 2003 Apr 1;13(7):568-74
chrolactomycin  0   *Diterpenes Telomerase/antagonists & inhibitors. Curr Biol 2006 Feb;13(2):183-90
trt1 protein, S pombe  0   *Telomerase *Schizosaccharomyces pombe Proteins.
Tert protein, mouse  EC 2.7.7.49   *Telomerase.
TERT protein, human  EC 2.7.7.49   *Telomerase.
EST2 protein, S cerevisiae  EC 2.7.7.49   *Telomerase *Saccharomyces cerevisiae Proteins.
PIF1 protein, human  EC 5.99.-   *DNA Helicases Telomerase/antagonists & inhibitors. Nucleic Acids Res 2006;34(5):1393-404
GRN163L peptide  0   *Oligonucleotides Telomerase. Hepatology 2005 Nov;42(5):1127-36
Zap3 protein, mouse  0   *Nucleoproteins Telomerase/antagonists & inhibitors. Mech Dev 2004 Dec;121(12):1509-22
EST3 protein, S cerevisiae  EC 2.7.7.49   *Telomerase *Saccharomyces cerevisiae Proteins.
2,6-bis(3-(N-piperidino)propionamido)anthracene-9,10-dione  0   *Anthraquinones *Piperidines Telomerase/antagonists & inhibitors. Gastroenterology 2004 May;126(5):1337-46
BIBR 1532  0   *Aminobenzoic Acids *Naphthalenes Telomerase/antagonists & inhibitors. EMBO J. 2001 Dec 17;20(24):6958-68; J Biol Chem 2002 May 3;277(18):15566-72
BisA compound  0   *Acridines *Bridged Compounds Telomerase/antagonists & inhibitors. J Biomol Struct Dyn 2001 Dec;19(3):505-13
6-thio-7-deaza-2'-deoxyguanosine 5'-triphosphate  0   *Deoxyguanine Nucleotides Telomerase/antagonists & inhibitors. Bioorg Chem 2001 Feb;29(1):36-55
PINX1 protein, human  0   *Tumor Suppressor Proteins Telomerase/antagonists & inhibitors. Cell 2001 Nov 2;107(3):347-59
3,11-difluoro-6,8,13-trimethyl-8H-quino(4,3,2-kl)acridinium  0   *Acridines Telomerase/antagonists & inhibitors. Mol Pharmacol 2001 Nov;60(5):981-8
telomerase reverse transcriptase (540-548)  EC 2.7.7.-   *Peptide Fragments *Telomerase. Eur J Immunol 2001 Sep;31(9):2642-51
telomestatin  0   *Oxazoles Telomerase. J Am Chem Soc 2001 Feb 14;123(6):1262-3
telomerase RNA  0   *RNA *Telomerase. Gene 1998 Oct 9;221(1):51-58; J Biol Chem 2001 Feb 23;276(8):5856-65
p95 protein, Tetrahymena  0   *RNA-Binding Proteins *Telomere-Binding Proteins Telomerase. Cell 1995 Jun 2;81(5):677-86
FSU oligonucleotide  0   *Oligonucleotides Telomerase/antagonists & inhibitors. Anal Biochem 2000 Jun 15;282(1):80-8
protelomerase protein, Bacteriophage N15  EC 2.7.7.-   *Enzyme Precursors *Viral Proteins *Telomerase. Proc Natl Acad Sci U S A 2000 Jul 5;97(14):7721-6
2-(3-(trifluoromethyl)phenyl)-isothiazolin-3-one  0   *Thiazoles Telomerase/antagonists & inhibitors. Biochemistry 1999 Aug 31;38(35):11501-7
diazaphilonic acid  0   *Benzopyrans *Carboxylic Acids Telomerase. J Antibiotic (Tokyo) 1999 Apr;52(4):412-4
alterperylenol  0   Perylene/*analogs & derivatives Telomerase/antagonists & inhibitors. Oncol Res 1998;10(8):449-53
N,N'-bis(2-1(piperidino)-ethyl)-3,4,9,10-perylene-tetracarboxylic diimide  0   *Piperidines Perylene/*analogs & derivatives Telomerase/antagonists & inhibitors. Nat Med 1998 Dec;4(12):1366-7
hTR RNA  0   *Telomerase *RNA, Untranslated. Curr Biol 1998 Jan 29;8(3):177-80
TEP1 protein, human  0   *Carrier Proteins Telomerase Vault Ribonucleoprotein Particles. Science 1997 Feb 14;275(5302):973-7
EST1 protein, S cerevisiae  EC 2.7.7.49   *Telomerase *Saccharomyces cerevisiae Proteins. Cell 1989 May 19;57(4):633-43
gamma-rubromycin  27267-71-6 Spiro(benzo(1,2-b:5,4-c')dipyran-2(3H),2'(3'H)-naphtho(2,3-b)furan)-7-carboxylic acid, 4,5',8',9-tetrahydro-4',9',10-trihydroxy-7'-methoxy-5',8',9-trioxo-, methyl ester  *Quinones Telomerase/antagonists & inhibitors. Mol Pharmacol 1990;38(1):20
beta-rubromycin  27267-70-5 Spiro(benzo(1,2-b:5,4-c')dipyran-2(3H),2'(3'H)-naphtho(1,2-b)furan)-7-carboxylic acid, 4,4',5',9-tetrahydro-6',10-dihydroxy-7',9'-dimethoxy-4',5',9-trioxo-, methyl ester  *Quinones Telomerase/antagonists & inhibitors. Mol Pharmacol 1990;38(1):20
alpha-rubromycin  27267-69-2 1H-2-Benzopyran-3-carboxylic acid, 6-(2-(4,9-dihydro-8-hydroxy-5,7-dimethoxy-4,9-dioxonaphtho(2,3-b)furan-2-yl)ethyl)-7,8-dihydroxy-1-oxo-, methyl ester  *Quinones Telomerase/antagonists & inhibitors. Mol Pharmacol 1990;38(1);20
tetra(4-N-methylpyridyl)porphine  38673-65-3 (4,4',4'',4'''-(21H,23H)-porphine-5,10,15,20- tetrayl)tetrakis(1-methylpyridinium)  *Porphyrins Telomerase/antagonists & inhibitors.
Pharma Action Anti-Infective Agents ; Enzyme Inhibitors ; Photosensitizing Agents ; Angiogenesis Inhibitors 		Nucleic Acids Res 6(9):3093;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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