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NADPH Oxidase

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Definition: A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.     
See Also Granulomatous Disease, Chronic 		Other names Oxidase, NADPH; NAD(P)H oxidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
respiratory burst oxidase homolog D, Arabidopsis  EC 1.6.-   *NADPH Oxidase *Arabidopsis Proteins. FEBS Lett. 2011 Oct 3;585(19):3006-10.
2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo(4,3-c)pyridine-3,6(2H,5H)-dione  0   *Pyrazoles *Pyridones NADPH Oxidase/antagonists & inhibitors. Am J Physiol Renal Physiol 2010 Dec;299(6):F1348-58
3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine  0   *Pyrimidines *Triazoles NADPH Oxidase/antagonists & inhibitors. Br J Pharmacol 2010 Oct;161(4):885-98
DUOX1 protein, C elegans  EC 1.6.3.1   *NADPH Oxidase *Caenorhabditis elegans Proteins. J Biol Chem. 2009 Jul 10;284(28):18634-43
dual oxidase protein, Zebrafish  0   *NADPH Oxidase *Zebrafish Proteins. Nature. 2009 Jun 18;459(7249):996-9
Nox3 protein, rat  EC 1.6.-   *NADPH Oxidase. J Neurosci 2008 Dec 3;28(49):13056-65
PG-L-1 compound  0   Prodigiosin/*analogs & derivatives NADPH Oxidase/antagonists & inhibitors. J Biochem 2008 Jan;143(1):107-15
NCF2 protein, human  EC 1.6.3.1   *NADPH Oxidase. Am J Hematol 2008 Feb;83(2):172
Duox1 protein, rat  EC 1.6.3.1   *NADPH Oxidase. Exp Cell Res 2007 Nov 1;313(18):3892-901
Nox protein, Drosophila  EC 1.6.3.1   *NADPH Oxidase. Free Radic Biol Med 2007 Jul 1;43(1):31-8
Duox1 protein, mouse  EC 1.6.3.1   *NADPH Oxidase. J Endocrinol 2007 Mar;192(3):615-26
p22-phox protein, rat  EC 1.6.3.1   *NADPH Oxidase. Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1497-508
p22(phox) protein, mouse  EC 1.6.3.1   *Cytochrome b Group *NADPH Oxidase. Arterioscler Thromb Vasc Biol 2006 Dec;26(12):2638-43
Ncf2 protein, mouse  EC 1.6.3.1   *NADPH Oxidase. J Immunol. 2006 Jun 1;176(11):6954-61
3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine  0   *Benzoxazoles *Triazoles NADPH Oxidase/antagonists & inhibitors. Biochem Biophys Res Commun 2006 May 26;344(1):200-5
dual oxidase, Drosophila  0   *NADPH Oxidase. Science 2005 Nov 4;310(5749):847-50
Cybb protein, rat  EC 1.6.-   *Membrane Glycoproteins *NADPH Oxidase. Arterioscler Thromb Vasc Biol 2000 Aug;20(8):1903-11
Nox4 protein, rat  EC 1.6.-   *NADPH Oxidase.
NOX4 protein, human  EC 1.6.3.-   *NADPH Oxidase.
dual oxidase Udx1, sea urchin  0   *NADPH Oxidase. Dev Cell 2004 Dec;7(6):801-14
Cybb protein, mouse  EC 1.6.3.1   *Membrane Glycoproteins *NADPH Oxidase. J Physiol 2003 Dec 15;553(Pt 3):833-41
Duox2 protein, rat  0   *Flavoproteins NADPH Oxidase.
Nox3 protein, mouse  EC 1.6.-   *NADPH Oxidase. Genes Dev 2004 Mar 1;18(5):486-91
Rhd2 protein, Arabidopsis  EC 1.6.-   *NADPH Oxidase *Arabidopsis Proteins. Nature 2003 Mar 27;422(6930):442-6
6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one  0   *Benzopyrans NADPH Oxidase/antagonists & inhibitors. Arterioscler Thromb Vasc Biol 2001 Oct;21(10):1577-84
NOX5 protein, human  EC 1.6.-   *Membrane Proteins *NADPH Oxidase. Gene 2001 May 16;269(1-2):131-40
Nox3 protein, human  EC 1.6.3.-   *Membrane Proteins *NADPH Oxidase. Gene 2001 May 16;269(1-2):131-40
DUOX2 protein, human  EC 1.6.3.1   *NADPH Oxidase. J Clin Endocrinol Metab 2001 Jul;86(7):3351-8
DUOX1 protein, human  EC 1.6.3.1   *NADPH Oxidase. J Cell Biol 2001 Aug 20;154(4):879-91; J Clin Endocrinol Metab 2001 Jul;86(7):3351-8
Nox4 protein, mouse  EC 1.6.-   *NADPH Oxidase. J Biol Chem 2001 Feb 23;276(8):5452-8
NOX1 protein, human  EC 1.6.3.-   *NADPH Oxidase Ion Channels. Science 2000 Jan 7;287(5450):138-42
NCF4 protein, human  EC 1.6.3.1   *NADPH Oxidase. Nat Med 1998 Jul;4(7):747-8
CYBA protein, human  EC 1.6.3.1   *NADPH Oxidase. Hum Genet 1994 Apr;93(4):437-42
neutrophil cytosol factor 67K  0   *Phosphoproteins NADH Dehydrogenase NADPH Dehydrogenase Neutrophils NADPH Oxidase. Biochem J 1993 Feb 15;290(Pt 1):173-8
neutrophil cytosolic factor 1  EC 1.6.3.1   *NADPH Oxidase Granulomatous Disease, Chronic. Science 1989;245(4916):409
CYBB protein, human  0   *Membrane Glycoproteins *NADPH Oxidase. Hematol Oncol Clin North Am 1988;2(2):225
cytochrome b558  9064-78-2 Cytochrome b 558  *Cytochrome b Group *NADPH Oxidase. J Bacteriol 1983;153(1):57
cytochrome b245  0   *Cytochrome b Group Granulomatous Disease, Chronic NADPH Oxidase. Biochem J 1982;204(2):479
oxophenylarsine  637-03-6   *Arsenicals NADPH Oxidase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Platelet Aggregation Inhibitors 		Biochemistry 1981;20(3):453
1-deaza-FAD  57818-88-9 adenosine 5'-(trihydrogen diphosphate), 5-5'-ester with 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxopyrimido(4,5-b)quinolin-10(2H)-yl)-D-ribitol  Flavin-Adenine Dinucleotide/*analogs & derivatives NADPH Oxidase/antagonists & inhibitors. Biochemistry 15(5):1043;1976; Biochemistry 16(6):3586;1977; J Biol Chem 1979;254(23):12145; J Biol Chem 1980;255(4):1420
superoxide-forming enzyme  EC 1.6.99.-   *NADPH Oxidase. J Clin Invest 63(1):21;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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