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Matrix Metalloproteinase 3

More information in Books or onNLM PubMed
Definition: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)  /antag is permitted but TISSUE INHIBITOR OF METALLOPROTEINASE-3 is available    Other names Metalloproteinase, MMP3; Metalloproteinase, MMP-3; Metalloproteinase 3, Matrix; MMP 3 Metalloproteinase; Stromelysin; MMP3 Metalloproteinase; MMP-3 Metalloproteinase; Transin; Stromelysin 1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(diethyl((methylsulfinyl)methyl)phosphonate)(dimethylmalonato)platinum(II)  0   *Organoplatinum Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3434-41
dichloro(diethyl((methylsulfinyl)methyl)phosphonate)platinum(II)  0   *Organoplatinum Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 12/antagonists & inhibitors. J Med Chem 2007 Jul 26;50(15):3434-41
Mmp3 protein, mouse  EC 3.4.24.17   *Matrix Metalloproteinase 3.
MMP3 protein, human  EC 3.4.24.17   *Matrix Metalloproteinase 3.
SM 25453  0   *Hydroxamic Acids Lysine/*analogs & derivatives Matrix Metalloproteinase 3. Biochem Biophys Res Commun 2006 May 26;344(1):315-22
YLL 224  0   *Imines *Indoles Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 7/antagonists & inhibitors Matrix Metalloproteinase 8/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Aug 11;274(3):780-6
MAG 283  0   *Amides *Sulfhydryl Compounds Matrix Metalloproteinase 3/antagonists & inhibitors Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors Matrix Metalloproteinase 1/antagonists & inhibitors Matrix Metalloproteinase 7/antagonists & inhibitors Matrix Metalloproteinase 8/antagonists & inhibitors. Biochem Biophys Res Commun 2000 Aug 11;274(3):780-6
Ro 26-2812  0   *Aminobiphenyl Compounds Matrix Metalloproteinase 3/antagonists & inhibitors. Protein Eng. 2000 Jun;13(6):397-405
PD 166793  0   *Hydroxamic Acids *Oligopeptides Matrix Metalloproteinase 3/antagonists & inhibitors. Biochemistry 1999 Oct 12;38(41):13592-601
PD 180557  0   *Hydroxamic Acids *Oligopeptides Matrix Metalloproteinase 3/antagonists & inhibitors. Biochemistry 1999 Oct 12;38(41):13592-601
3-((benzyl)(methylaminocarbonyl)methylaminocarbonyl)N-hydroxy-5-methylhexanamide  108383-58-0   *Hydroxamic Acids Matrix Metalloproteinase 3/antagonists & inhibitors. J Protein Chem 1998 Oct;17(7):699-712
CT 1418  0   *Hydroxamic Acids *Sulfonamides Matrix Metalloproteinase 3/antagonists & inhibitors. J Protein Chem 1998 Oct;17(7):699-712
PNU 107859  0   *Thiadiazoles Urea/*analogs & derivatives Matrix Metalloproteinase 3/antagonists & inhibitors. Protein Sci 1998 Nov;7(11):2281-6
PNU 142372  0   *Thiadiazoles Urea/*analogs & derivatives Matrix Metalloproteinase 3/antagonists & inhibitors. Protein Sci 1998 Oct;7(10):2118-26
PNU 141803  0   *Thiadiazoles Matrix Metalloproteinase 3/antagonists & inhibitors. Protein Sci 1998 Oct;7(10):2118-26
CGS 27023  0   *Hydroxamic Acids Matrix Metalloproteinase 3/antagonists & inhibitors. Biochemistry 1998 Oct 6;37(40):14048-56
L 758354  0   *Dipeptides Matrix Metalloproteinase 3/antagonists & inhibitors. J Med Chem 1997 Mar 14;40(6):1026-40
GM 6001  0   *Dipeptides Metalloendopeptidases/antagonists & inhibitors Matrix Metalloproteinase 3/antagonists & inhibitors.
Pharma Action Protease Inhibitors 		Invest Ophthalmol Vis Sci 1992 Nov;33(12):3325-31

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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