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1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine

More information in Books or onNLM PubMed
Definition: A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.  DF: IQSMP   
Pharmacological Action Enzyme Inhibitors 		Other names H 7; 1-(5-Isoquinolinylsulfonyl)-2-Methylpiperazine; H-7
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-methyl-hydroxyfasudil  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Carbon Radioisotopes. Appl Radiat Isot 2010 Feb;68(2):325-8
2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives. J Neurochem 2002 Apr;81(1):9-16
hydroxyfasudil  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives. J Cereb Blood Flow Metab 2001 Jul;21(7)876-85
HA 1100  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Protein Kinase Inhibitors. Eur J Pharmacol 1998 Nov 6;360(2-3):257-64
HMN 1180  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Nitric Oxide Synthase/antagonists & inhibitors. J Pharmacol Exp Ther 1998 Dec;287(3):1063-7
1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine  0   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Protein-Serine-Threonine Kinases/antagonists & inhibitors. FEBS Lett 1998 Feb 6;422(3):363-7
1-(5-isoquinolinylsulfonyl)-3-methylpiperazine  84477-73-6   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors.
Pharma Action Protein Kinase Inhibitors 		Biochem Biophys Res Commun 1993 Mar 31;191(3):928-36
KN 04  129695-80-3   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Protein Kinase Inhibitors. J Pharmacol Exp Ther 1990;254(2):598
KN 62  127191-97-3 5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester, (S)  1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Biol Chem 1990;265(8):4315
1-(5-isoquinolinesulfonyl)piperazine  84468-24-6   1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. J Biol Chem 1987;262(14):6643
fasudil  103745-39-7 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)  1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/*analogs & derivatives.
Pharma Action Calcium Channel Blockers ; Vasodilator Agents ; Protein Kinase Inhibitors 		J Neurosurg 1986;65(1):80

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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