encyclopedia of medical concepts
ψ 
ψ 
ψ 

Endothelin-1

More information in Books or onNLM PubMed
Definition: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)  /drug eff permitted    Other names Proendothelin 1 Precursor; Preproendothelin 1; Precursor, Proendothelin-1; Endothelin-1, Big; Endothelin 1; Big Endothelin 1; Proendothelin-1 Precursor; Proendothelin (1-38); Preproendothelin-1; Preproendothelin; Endothelin, Big; Endothelin Type 1; ET-1 (Endothelin-1); Big Endothelin-1; Big Endothelin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
C-terminal proendothelin-1  0   *Peptide Fragments *Endothelin-1. Am Heart J 2007 Oct;154(4):736-42
atrasentan  0 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxo-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, (2R,3R,4S)  *Pyrrolidines Endothelin-1/antagonists & inhibitors. JAMA 2001 Jul 4;286(1):34
endothelin-1 (1-21)  0   *Peptide Fragments Endothelin-1/*analogs & derivatives. FEBS Lett 2000 Dec 29;487(2):194-8
edn1 protein, zebrafish  0   *Endothelin-1 *Zebrafish Proteins. Development 2000 Sep;127(17):3815-28
endothelin-1, (Aib(1,3,11,15),Nle(7))  0   Endothelin-1/*analogs & derivatives. Neurochem Int 1999 Jul;35(1):35-45
endothelin-1 (1-21), (Cys,Acm(1,15),Aib(3,11),Leu(7))  0   *Peptide Fragments *Endothelin-1. J Pept Res 1999 Mar;53(3):223-33
ET-1(Cys(Acm)(1,15)-Ala(3)-Leu(7)-dAsp(8)-Aib(11))  0   Endothelin-1/*analogs & derivatives. J Biomol Struct Dyn 1998 Oct;16(2):425-35
(Sec(3)-Sec(11)-Nle(7))-endothelin-1  0   Endothelin-1/*analogs & derivatives. J Mol Biol 1998 Dec 4;284(3):779-92
endothelin-1 (1-31)  0   *Peptide Fragments Endothelin-1/*analogs & derivatives. Eur J Pharmacol 1998 May 8;348(2-3):305-9
endothelin-1, Cys(Acm)(1,15)-Ala(3)-Leu(7)-Aib(11)  0   Endothelin-1/*analogs & derivatives Receptors, Endothelin/agonists. FEBS Lett 1998 Mar 27;425(2):234-8
endothelin-1, Thr(18)-Leu(19)  0   Endothelin-1/*analogs & derivatives Receptors, Endothelin/antagonists & inhibitors. Eur J Pharmacol 1997 May 1;325(2-3):263-70
endothelin-1, Thr(18)-Cha(19)  0   Endothelin-1/*analogs & derivatives Receptors, Endothelin/antagonists & inhibitors. Eur J Pharmacol 1997 May 1;325(2-3):263-70
CGS 26061  0   *Pyrimidinones *Thiazines Endothelin-1/antagonists & inhibitors. Biochem Biophys Res Commun 1996 Oct 3;227(1):176-81
endothelin-1, Ala(10)  0   Endothelin-1/*analogs & derivatives Receptors, Endothelin/antagonists & inhibitors. Eur J Pharmacol 1995 May 15;278(2):103-9
proendothelin 1  0   *Protein Precursors *Endothelin-1. FEBS Lett 1995 Apr 10;362(3):276-80
endothelin-1, lysyl(-2)-arginyl(-1)  0   Endothelin-1/*analogs & derivatives. Biochemistry 1995 Apr 11;34(14):4546-61
endothelin-1, Pen(1,11)-Nle(7)-Ala(18)  0   Endothelin-1/*analogs & derivatives. Bioorg Med Chem 1993 Jul;1(1):59-65
endothelin-1, Pen(1,11)-Nle(7)-Asn(18)  0   Endothelin-1/*analogs & derivatives. Bioorg Med Chem 1993 Jul;1(1):59-65
endothelin-1, Aba(1,15)  153094-75-8   Endothelin-1/*analogs & derivatives. J Med Chem 1994 Mar 4;37(5):656-64
endothelin-1, formylTrp(21)  0   Endothelin-1/*analogs & derivatives. Br J Pharmacol 1993 Jul;109(3):880-6
endothelin-1, Phe(16)  0   Endothelin-1/*analogs & derivatives. Biochem Biophys Res Commun 1992 Mar 16;183(2):572-6

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy