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Disintegrins

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Definition: A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.  polypeptides from snake venom; platelet aggregation inhib   
Pharmacological Action Platelet Aggregation Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
insularin, Bothrops insularis  0   *Crotalid Venoms *Disintegrins. Toxicon. 2011 Jan;57(1):125-33
mojastin protein, Crotalus scutulatus  0   *Disintegrins. Toxicol Appl Pharmacol 2006 Apr 1;212(1):59-68
jerdostatin, Protobothrops jerdonii  0   *Disintegrins Platelet Aggregation Inhibitors Recombinant Proteins. Toxicon. 2010 Nov;56(6):1052-8
acurhagin-C protein, Agkistrodon acutus  0   *Peptide Fragments *Disintegrins Crotalid Venoms. Br J Pharmacol 2010 Jul;160(6):1338-51
vicrostatin  0   *Disintegrins. Pathophysiol Haemost Thromb 2005;34(4-5):177-83
cumanastatin 1, Crotalus durissus cumanensis  0   *Crotalid Venoms *Disintegrins. Thromb Res 2009 Mar;123(5):731-9
stejnin protein, Trimeresurus stejnegeri  0   *Viper Venoms *Disintegrins. Protein Pept Lett 2007;14(5):437-41
bitisgabonin-2  0   *Viper Venoms *Disintegrins. J Proteome Res 2007 Jan;6(1):326-36
bitisgabonin-1  0   *Viper Venoms *Disintegrins. J Proteome Res 2007 Jan;6(1):326-36
bothrostatin, Bothrops jararaca  EC 3.4.-   *Disintegrins *Metalloproteases. Biochem Biophys Res Commun 2005 Apr 8;329(2):457-64
ADAM3A protein, human  EC 3.4.24.-   *ADAM Proteins Disintegrins.
Adam33 protein, mouse  EC 3.4.24.-   *ADAM Proteins Zinc Fingers Disintegrins.
adinbitor protein, Agkistrodon halys brevicaudus stejneger  0   *Crotalid Venoms *Disintegrins. Acta Biochim Biophys Sin (Shanghai) 2004 Jun;36(6):425-9
Adam3 protein, mouse  EC 3.4.24.-   *Membrane Glycoproteins *ADAM Proteins Disintegrins.
jerdonin  0   *Disintegrins Venoms. Toxicon. 2004 Jan;43(1):69-75
alternagin-C  0   *Disintegrins. Eur J Biochem. 2003 Dec;270(24):4799-808
trimestatin protein, Trimeresurus flavoviridis  0   *Disintegrins Viper Venoms. J Mol Biol 2003 Oct 3;332(5):1115-22
UNC-71 protein, C elegans  EC 3.4.24.-   *Metalloendopeptidases *Caenorhabditis elegans Proteins Disintegrins. Development 2003 Jul;130(14):3147-61
ADAM32 protein, human  EC 3.4.24.-   *ADAM Proteins Disintegrins. Gene 2003 Jan 30;304:151-62
saxatilin  0   *Disintegrins. Biochem Biophys Res Commun 2002 Apr 26;293(1):530-6
acostatin  0   *Disintegrins Snake Venoms. Acta Crystallogr D Biol Crystallogr 2002 Jan;58(Pt 1):145-7
ADAM33 protein, human  EC 3.4.24.-   *ADAM Proteins Zinc Fingers Disintegrins. Gene 2002 Jan 9;282(1-2):227-36
ocellatusin  0   *Viper Venoms *Disintegrins. FEBS Lett 2002 Feb 13;512(1-3):111-5
piscivostatin  0   *Disintegrins. J Biochem (Tokyo) 2001 Sep;130(3):407-15
EC6 protein, Echis carinatus sochureki  0   *Viper Venoms *Disintegrins. J Biol Chem 2000 Oct 13;275(41):31930-7
ADAM19 protein, human  EC 3.4.24.-   *ADAM Proteins Biological Markers Disintegrins. Blood 2000 Jul 15;96(2):732-9
MIG-17 protein, C elegans  0   *Metalloendopeptidases *Disintegrins *Caenorhabditis elegans Proteins Muscle Proteins. Science 2000 Jun 23;288(5474):2205-8
ADAM28 protein, human  EC 3.4.24.-   *ADAM Proteins Membrane Glycoproteins Disintegrins. Biochem J 2000 May 15;348 Pt 1;21-7; Mol Hum Reprod 1999 Dec;5(12):1127-34
contortrostatin  0   *Disintegrins. Biochem Biophys Res Commun 2000 Jan 7;267(1):350-5
ADAM30 protein, human  EC 3.4.24.-   *ADAM Proteins Membrane Proteins Disintegrins. Biochem Biophys Res Commun 1999 Oct 5;263(3):810-5
ADAM29 protein, human  EC 3.4.24.-   *ADAM Proteins Membrane Proteins Disintegrins. Biochem Biophys Res Commun 1999 Oct 5;263(3):810-5
EMF10 protein, Eristocophis macmahoni  0   *Viper Venoms *Disintegrins Receptors, Fibronectin/antagonists & inhibitors. Biochemistry 1999 Oct 5;38(40):13302-9
jarastatin  0   *Disintegrins Crotalid Venoms. Exp Cell Res 1999 Sep 15;251(2):379-87
Adam18 protein, mouse  EC 3.4.24.-   *Membrane Glycoproteins *ADAM Proteins Disintegrins. Gene 1999 Jul 8;234(2):227-37
Adam26a protein, mouse  EC 3.4.24.-   *Membrane Glycoproteins *ADAM Proteins Disintegrins. Gene 1999 Jul 8;234(2):227-37
Adam25 protein, mouse  EC 3.4.24.-   *Membrane Glycoproteins *ADAM Proteins Disintegrins. Gene 1999 Jul 8;234(2):227-37
Adam24 protein, mouse  EC 3.4.24.-   *Membrane Glycoproteins *ADAM Proteins Disintegrins. Gene 1999 Jul 8;234(2):227-37
EC3 protein, Echis carinatus  0   *Viper Venoms *Disintegrins. J Biol Chem 1999 Apr 30;274(18):12468-73
ussuristatin 2 protein, Gloydius ussuriensis  0   *Viper Venoms *Disintegrins. J Biochem (Tokyo) 1999 Jan;125(1):31-5
ussuristatin 1 protein, Gloydius ussuriensis  0   *Viper Venoms *Disintegrins. J Biochem (Tokyo) 1999 Jan;125(1):31-5
accutin  0   *Crotalid Venoms *Disintegrins Apoptosis. Blood 1998 Nov 1;92(9):3268-76
flavorodin  0   *Disintegrins. Blood 1998 Nov 1;92(9):3240-9
ADAM23 protein, human  EC 3.4.24.-   *ADAM Proteins Disintegrins. Biochem J 1998 Aug 15;334(Pt 1):93-6
decysin  EC 3.4.24.-   *Metalloendopeptidases Disintegrins. J Exp Med 1997 Aug 29;186(5):655-63
ADM-1 protein, C elegans  EC 3.4.24   *Metalloendopeptidases *Caenorhabditis elegans Proteins Disintegrins. Mol Biol Cell 1996 Dec;7(12):1877-93
ADAM 12 protein  EC 3.4.24.-   *Membrane Proteins *ADAM Proteins Disintegrins. Biochem Biophys Res Commun 1997 Jan 13;230(2):335-9
flavostatin  0   *Disintegrins Crotalid Venoms. Biochimie 1996;78(4):245-52
kuzbanian protein, Drosophila  EC 3.4.24.-   *Metalloendopeptidases *Disintegrins *Drosophila Proteins. Science 1996 Aug 30;273(5279):1227-31
kistrin  0   *Peptides Crotalid Venoms Platelet Aggregation Receptors, Vitronectin/antagonists & inhibitors Disintegrins.
Pharma Action Fibrinolytic Agents 		Circulation 1991;83(3):1038
Agkistrodon venoms  0   *Crotalid Venoms Metalloendopeptidases Disintegrins. Toxicon 1981(19)(2):334

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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