Definition: A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
DF: HMWK
Other names Kininogens, High-Molecular-Weight; Kininogen, High Molecular Weight; Kininogens, High Molecular Weight; High-Molecular-Weight Kininogens; High Molecular Weight Kininogens; High Molecular Weight Kininogen; HMWK; Fitzgerald Factor; High-Molecular-Weight Kininogen
