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Glycyrrhizic Acid

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Definition: A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.  do not confuse with GLYCYRRHETINIC ACID   
Pharmacological Action Anti-Inflammatory Agents 		Other names Glycyrrhizinate, Dipotassium; Glycyrrhizinate, Diammonium; Glycyrrhizate, Zinc; Acid, Glycyrrhizinic; Acid, Glycyrrhizic; Zinc Glycyrrhizate; Glycyrrhizinic Acid; Dipotassium Glycyrrhizinate; Diammonium Glycyrrhizinate; Glycyrrhizin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Viusid  0   *Zinc *Ascorbic Acid *Glycyrrhizic Acid Hepatitis C, Chronic/drug therapy. World J Gastroenterol. 2010 Jun 7;16(21):2638-47
simvaglyzin  0   *Glycyrrhizic Acid *Simvastatin. Biomed Khim. 2008 May-Jun;54(3):301-13
alaglyzin  0   *Glycyrrhizic Acid Aconitine/*analogs & derivatives. Eksp Klin Farmakol 2005 Jul-Aug;68(4):24-7
Phosphogliv  0   *Phosphatidylcholines *Glycyrrhizic Acid Drug Combinations. Biomed Khim. 2003 Sep-Oct;49(5):484-90
glycyrrhizic acid penta-O-nicotinate  0   Niacin/*analogs & derivatives Glycyrrhizic Acid/*analogs & derivatives. Vestn Ross Akad Med Nauk. 2004;(11):42-6
phospholiv  0   *Phosphatidylcholines Drug Combinations Glycyrrhizic Acid/*analogs & derivatives. Vopr Med Khim 1998 Nov-Dec;44(6):537-43
glycyrrhizic acid methyl ester  104191-95-9   Glycyrrhizic Acid/*analogs & derivatives. Bioorg Khim 1989;15(3):392

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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