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Peptidylprolyl Isomerase

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Definition: An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8.     
Examples Immunophilins 		Other names cis-trans-Isomerase, Peptidyl-Prolyl; Rotamase, Proline; Peptidyl Prolyl cis trans Isomerase; Isomerase, Prolyl; Isomerase, Proline; Isomerase, Peptidylprolyl; Proline Rotamase; Proline Isomerase; Prolyl Isomerase; Peptidyl-Prolyl cis-trans-Isomerase; PPIase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cysteinyl-arginyl-tyrosyl-prolyl-glutamyl-valyl-glutamyl-isoleucyl-cysteine (1-9) disulfide  0   *Peptides, Cyclic Peptidylprolyl Isomerase/antagonists & inhibitors. J Med Chem 2011 Jun 9;54(11):3854-65
2-(3-chloro-4-fluorophenyl)isothiazol-3-one  0   *Thiazoles Peptidylprolyl Isomerase/antagonists & inhibitors Cyclophilins/antagonists & inhibitors. Biochem Biophys Res Commun 2011 Mar 18;406(3):439-43
diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate  0   *Phenanthrolines Peptidylprolyl Isomerase/antagonists & inhibitors. Chem Biol 2003 Jan;10(1):15-24
PrsA2 protein, Listeria monocytogenes  EC 5.2.1.8   *Peptidylprolyl Isomerase. Infect Immun 2009 Jul;77(7):2612-23
dipentamethylene thiuram monosulfide  0   *Piperidines Thiram/*analogs & derivatives Peptidylprolyl Isomerase/antagonists & inhibitors. Biochem Biophys Res Commun 2009 Jul 3;384(3):394-8
PpiD protein, E coli  EC 5.2.1.-   *Peptidylprolyl Isomerase *Escherichia coli Proteins. FEBS J 2008 Jul;275(13):3470-9
acetyl-phenylalanyl-phosphothreonyl-piperidine-2-carboxylic acid-2-naphthylalanyl-glutaminamide  0   *Oligopeptides Peptidylprolyl Isomerase/antagonists & inhibitors. Biol Chem 2007 Oct;388(10):1103-11
Pin1 protein, Xenopus  EC 5.2.18   *Peptidylprolyl Isomerase *Xenopus Proteins. Biol Chem 2007 Oct;388(10):1103-11
XC2699 protein, Xanthomonas campestris  EC 5.2.1.-   *Bacterial Proteins *Peptidylprolyl Isomerase. Mol Plant Microbe Interact 2007 Jan;20(1):21-30
Mip protein, Legionella pneumophila  EC 5.2.1.8   *Bacterial Proteins *Peptidylprolyl Isomerase.
PPIL1 protein, human  EC 5.2.1.8   *Peptidylprolyl Isomerase. J Biol Chem 2006 Jun 9;281(23):15900-8
SlrA protein, Streptococcus pneumoniae  EC 5.2.1.8   *Peptidylprolyl Isomerase. J Biol Chem 2006 Jan 13;281(2):968-76
Par10 protein, E coli  EC 5.2.1.8   *Peptidylprolyl Isomerase *Escherichia coli Proteins. Protein Sci 2004 Sep;13(9):2378-87
SurA protein, E coli  EC 5.2.1.-   *Carrier Proteins *Peptidylprolyl Isomerase *Escherichia coli Proteins.
RRD1 protein, S cerevisiae  EC 5.2.1.8   *Peptidylprolyl Isomerase *Saccharomyces cerevisiae Proteins *Intracellular Signaling Peptides and Proteins.
cyclophilin H, human  EC 5.2.1.-   *Peptidylprolyl Isomerase Cyclophilins. J Mol Biol. 2003 Aug 1;331(1):45-56
KIN241 protein, Paramecium tetraurelia  EC 5.2.1.8   *Nuclear Proteins *Protozoan Proteins *RNA-Binding Proteins Peptidylprolyl Isomerase. Mol Microbiol 2001 Oct;42(1):257-67
DlPar13 protein, Digitalis lanata  EC 5.2.1.-   *Plant Proteins *Peptidylprolyl Isomerase. J Biol Chem 2001 Apr 27;276(17):13524-9
Pin1 protein, Malus domestica  EC 5.2.1.-   *Peptidylprolyl Isomerase. J Biol Chem 2001 Apr 27;276(17):13517-23
peptidyl-prolyl cis-trans isomerase b  EC 5.2.1.-   *Peptidylprolyl Isomerase Isoenzymes. J Biomol NMR 2000 Sep;18(1):75-6
trigger factor, E coli  EC 5.2.1.-   *Peptidylprolyl Isomerase *Escherichia coli Proteins. Protein Sci 2000 Jun;9(6):1254-61
pimecrolimus  0   Tacrolimus/*analogs & derivatives Peptidylprolyl Isomerase/antagonists & inhibitors Calcineurin/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Dermatologic Agents ; Immunosuppressive Agents 		J Pharmacol Exp Ther 1999 Feb;288(2):653-9ELIDEL
cyproase 1  EC 3.4.99.-   *Endopeptidases *Peptidylprolyl Isomerase. Nature 1998 Jan 15;391(6664):301-4
ILPA protein, Aeromonas hydrophila  EC 5.2.1.8   *Bacterial Proteins *Peptidylprolyl Isomerase. J Bacteriol 1997 Jun;179(11):3397-403
NIMA-interacting peptidylprolyl isomerase  0   *Peptidylprolyl Isomerase Arabidopsis Proteins Saccharomyces cerevisiae Proteins Escherichia coli Proteins. Nature 1996 Apr 11;380(6574):544-7
periplasmic peptidylprolyl cis-trans isomerase  EC 5.2.1.-   *Carrier Proteins *Peptidylprolyl Isomerase. J Bacteriol 1996 Mar;178(6):1770-3
Dodo protein, Drosophila  EC 5.2.1.8   *Peptidylprolyl Isomerase *Drosophila Proteins. Proc Natl Acad Sci U S A 1996 Jan 9;93(1):447-51
SlyD protein, E coli  0   *Peptidylprolyl Isomerase *Escherichia coli Proteins. J Biol Chem 1994 Jan 28;269(4):2902-10
FkpA protein, E coli  EC 5.2.1.8.   *Membrane Proteins *Peptidylprolyl Isomerase *Escherichia coli Proteins. Mol Microbiol 1991;5(1):109
juglone  481-39-0 5-hydroxy-1,4- naphthalenedione  *Naphthoquinones Pigments, Biological Potassium Channels/antagonists & inhibitors Peptidylprolyl Isomerase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Cytotoxins ; Enzyme Inhibitors ; Food Preservatives 		Biochem Pharmacol 25(6):669;1976; J Biochem (Tokyo) 79(1-2):146;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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