encyclopedia of medical concepts
ψ 
ψ 

Thrombospondins

More information in Books or onNLM PubMed
Definition: A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.  membrane glycoproteins; THROMBOSPONDIN 1 is also available   
Examples Thrombospondin 1 		Other names Thrombospondin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
THSD7B protein, human  0   *Thrombospondins. J Psychiatr Res. 2011 Nov;45(11):1419-25
thrombospondin type I domain containing 7A, zebrafish  0   *Thrombospondins *Zebrafish Proteins Nerve Tissue Proteins. Dev Dyn 2011 Jun;240(6):1412-21
thrombospondin type I domain containing 7A protein, human  0   *Thrombospondins. J Cell Physiol. 2010 Mar;222(3):685-94
R-spondin 3 protein, Xenopus  0   *Thrombospondins *Xenopus Proteins. Development. 2008 Nov;135(22):3655-64
FIG-1 protein, C elegans  0   *Thrombospondins *Caenorhabditis elegans Proteins. Science. 2008 Oct 31;322(5902):744-7
RSPO4 protein, mouse  0   *Thrombospondins. Gene Expr Patterns 2007 Jan;7(3):306-12
RSPO2 protein, mouse  0   *Thrombospondins. Gene Expr Patterns 2007 Jan;7(3):306-12
RSPO1 protein, mouse  0   *Thrombospondins. Biochim Biophys Acta 2004 Jan 5;1676(1):51-62
R-spondin3 protein, mouse  0   *Thrombospondins Pregnancy Proteins. Dev Biol 2007 Jan 1;301(1):218-26
RSPO4 protein, human  0   *Thrombospondins. Nat Genet 2006 Nov;38(11):1245-7
Tmtsp protein, mouse  0   *Thrombospondins. Blood 2006 Jun 1;107(11):4317-25
THSD1 protein, human  0   *Thrombospondins. Blood 2006 Jun 1;107(11):4317-25
SPATR protein, Plasmodium knowlesi  0   *Antigens, Protozoan Thrombospondins. Infect Immun 2005 Sep;73(9):5402-9
RSPO1 protein, human  0   *Thrombospondins. Science. 2005 Aug 19;309(5738):1256-9
ISM2 protein, human  0   *Thrombospondins. Gene 2004 Jun 23;335:101-8
ADAMTSL4 protein, human  0   *Thrombospondins.
SPATR protein, Plasmodium falciparum  0   *Protozoan Proteins Thrombospondins. J Biol Chem 2003 Jul 11;278(28):25977-81
RSPO3 protein, human  0   *Thrombospondins. Mol Biol Rep 2002 Sep;29(3):287-92
Tsrc1 protein, mouse  0   *Thrombospondins. Gene 2003 Mar 27;307:23-30
GMP-33 protein, human  0   *Peptide Fragments *Thrombospondins. Thromb Haemost 2001 Sep;86(3):887-93
thrombospondin 4  0   *Thrombospondins Cell Adhesion Molecules.
thrombospondin 3  0   *Thrombospondins Cell Adhesion Molecules.
thrombospondin 2  0   *Thrombospondins Cell Adhesion Molecules.
thrombospondin-related adhesive protein, protozoan  120300-02-9   *Protozoan Proteins Plasmodium Cell Adhesion Molecules Thrombospondins. Proc R Soc Lond (Biol) 1990;242(1305):205

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy