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Calcineurin

More information in Books or onNLM PubMed
Definition: A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.      Other names Protein Phosphatase 2B; Phosphatase 3, Protein; Protein Phosphatase 3 Regulatory Subunit; Protein Phosphatase 3 Catalytic Subunit; Protein Phosphatase 3; Protein Phosphatase-2B; Calcineurin B; Calcineurin A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PBO-1 protein, C elegans  0   *Calcineurin *Caenorhabditis elegans Proteins. Am J Physiol Cell Physiol. 2011 Dec;301(6):C1389-403
protein phosphatase 3, catalytic subunit, beta isoform, mouse  EC 3.1.3.16   *Calcineurin. Clin Immunol. 2011 Mar;138(3):321-30
6-(3,4-dichlorophenyl)-4-(N,N-dimethylaminoethylthio)-2-phenylpyrimidine  0   *Pyrimidines Calcineurin/antagonists & inhibitors. J Biol Chem 2010 Jan 15;285(3):1888-98
PPP3R1 protein, human  EC 3.1.3.16   *Calcineurin.
PPP3CC protein, human  EC 3.1.3.16   *Calcineurin.
PPP3CB protein, human  EC 3.1.3.16   *Calcineurin.
PPP3CA protein, human  EC 3.1.3.16   *Calcineurin.
PPP3R2 protein, human  EC 3.1.3.16   *Calcineurin. Mol Biol Rep. 2005 Mar;32(1):41-5
Dscr1l1 protein, mouse  0   *Proteins Calcineurin.
RCN1 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *Intracellular Signaling Peptides and Proteins Calcineurin.
CBL protein, Arabidopsis  0   *Calcium-Binding Proteins *Arabidopsis Proteins Calcineurin. Plant Cell 1999 Dec;11(12):2393-405
pimecrolimus  0   Tacrolimus/*analogs & derivatives Peptidylprolyl Isomerase/antagonists & inhibitors Calcineurin/antagonists & inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Dermatologic Agents ; Immunosuppressive Agents 		J Pharmacol Exp Ther 1999 Feb;288(2):653-9ELIDEL
Cabin1 protein, mouse  0   *Phosphoproteins *Calcineurin. Immunity 1998 Jun;8(6):703-11
RCAN1 protein, human  0   *Muscle Proteins *Intracellular Signaling Peptides and Proteins Calcineurin/antagonists & inhibitors. Genomics 1997 Sep 15;44(3):358-61
RCAN2 protein, human  0   *Muscle Proteins Calcineurin/antagonists & inhibitors. J Biol Chem 1996 Jun 14;271(24):14567-71
calcineurin Balpha2  EC 3.1.3.-   *Calcineurin. Biochim Biophys Acta 1994 Mar 1;1217(2):174-80
Ppp3r2 protein, rat  143242-08-4   *Calcineurin. Biochem Biophys Res Commun 1991;179(3):1325
CMP2 protein, S cerevisiae  EC 3.1.3.16   *Calcineurin *Saccharomyces cerevisiae Proteins. Proc Natl Acad Sci USA 1991;88(16):7376
CNA1 protein, S cerevisiae  EC 3.1.3.16   *Calcineurin *Saccharomyces cerevisiae Proteins. Proc Natl Acad Sci USA 1991;88(16):7376

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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