Receptors (definition)

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Receptors, Chemokine

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Definition: Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.

DF: RECEPT CHEMOKINE
Examples Receptors, CCR; Receptors, CXCR

Other names Chemokine Receptors

Substance	Categories	Source
XC chemokine receptor 1, mouse	*Receptors, Chemokine.	FEBS Lett 1999 Sep 10;458(1):37-40
Evasin-1, Rhipicephalus sanguineus	*Receptors, Chemokine.	J Biol Chem 2007 Sep 14;282(37):27250-8
CXCR6 protein, rat	*Receptors, Chemokine.	Immunology 2007 Aug;121(4):555-64
CX3CR1 protein, rat	*Receptors, Chemokine.	Neurosci Lett 1994 Mar 14;169(1-2):85-9
Ccbp2 protein, rat	*Receptors, Chemokine.
Ccbp2 protein, mouse	*Receptors, Chemokine.
CCBP2 protein, human	*Receptors, Chemokine.
Gpr77 protein, mouse	*Receptors, Chemokine.	J Biol Chem 2005 Dec 2;280(48):39677-80
Gr-1 protein, mouse	*Receptors, Chemokine.	J Exp Med. 2005 Jun 6;201(11):1761-9
2-(N-methyl-N-(((4-(3-benzyl-1-ethyl-(1H)-pyrazol-5-yl)piperidin-1-yl)methyl)-4-(3-fluorophenyl)cyclopent-1-yl)amino)-3-methylbutanoic acid	Pyrazoles Valine/analogs & derivatives Receptors, Chemokine/antagonists & inhibitors.	J Pharmacol Exp Ther 2003 Mar;304(3):1161-71
Cx3cr1 protein, mouse	*Receptors, Chemokine.	J Clin Invest 2003 Feb;111(3):333-40
US27 protein, human cytomegalovirus	Viral Proteins Receptors, Chemokine.	Traffic 2002 Mar;3(3):218-32
UL33 protein, human cytomegalovirus	Viral Proteins Receptors, Chemokine.	Virology 1996 Nov 1;225(1):111-25
3-(1-(((3-(3,4-dichlorophenyl)propenoyl)amino)pentyl)piperidin-4-yl)-5-hydroxyindole	Indoles Piperidines Receptors, Chemokine/antagonists & inhibitors.	Bioorg Med Chem Lett 2000 Aug 21;10(16):1803-6
GPR77 protein, human	*Receptors, Chemokine.	Mol Immunol. 2000 Jun;37(8):407-12
UCB 35625	*Xanthenes Stereoisomerism Receptors, Chemokine/antagonists & inhibitors.	J Biol Chem 2000 Aug 25;275(34):25985-92
BX 471	Phenylurea Compounds Piperidines Receptors, Chemokine/antagonists & inhibitors.	J Biol Chem 2000 Jun 23;275(25):19000-8
US28 receptor, Cytomegalovirus	Viral Proteins Receptors, Chemokine.
U51 protein, human herpesvirus 6	Receptors, Virus Receptors, Chemokine Viral Proteins.	J Immunol 2000 Mar 1;164(5):2396-404
E1 protein, Equid herpesvirus 2	Viral Proteins Receptors, Chemokine.	J Virol 1999 Dec;73(12):9843-8
4-(4-chlorophenyl)-4-hydroxy-alpha,alpha-diphenyl-1-piperidinepentanenitrile	Nitriles Piperidines Receptors, Chemokine/antagonists & inhibitors.	J Med Chem 1999 Nov 4;42(22):4659-68
G protein-coupled receptor, Human herpesvirus 8	*Receptors, Chemokine Viral Proteins.	J Clin Invest 1998 Oct 15;102(8):1469-72
Ccrl2 protein, mouse	*Receptors, Chemokine.	FEBS letters 1998 Apr 3;425(3):490-4
Cmklr1 protein, rat	*Receptors, Chemokine.	Biochem Biophys Res Commun 1997 Dec 18;241(2):390-4
CXCR6 protein, human	Receptors, Virus Receptors, Chemokine.	J Exp Med 1997 Jun 2;185(11):2015-23
ORF74 protein, Human herpesvirus 8	Viral Proteins Receptors, Chemokine.	Virology 1997 Feb 17;228(2):371-8
CMKLR1 protein, human	*Receptors, Chemokine.	Cytogenet Cell Genet 1996;74(4):286-90; Eur J Immunol 1998 May;28(5):1689-700
CX3CR1 protein, human	*Receptors, Chemokine.	DNA Cell Biol 1995 Aug;14(8):673-80; Nephrol Dial Transplant 2002 May;17(5):734-44
macrophage inflammatory protein 1alpha receptor	*Receptors, Chemokine.	Cell Growth Differ 1993 Mar;4(3):137-46

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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