Receptors (definition)

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Receptors, CCR5

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Definition: CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells.

DF: RECEPT CCR5

Other names Receptor, CCR5; Receptors, CKR5; CKR5 Receptors; CCR5 Receptor; CC-CKR5; CD195 Antigens; CCR5 Receptors; CC Chemokine Receptor 5; Antigens, CD195

Substance	CAS Registry & name	Categories	Source	Drugs*
nifeviroc	0	Carbamates Pyrrolidines Receptors, CCR5/antagonists & inhibitors.	Bioorg Med Chem Lett. 2010 Jul 15;20(14):4012-4.
4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid	0	Benzoic Acids Diketopiperazines Receptors, CCR5/antagonists & inhibitors.	Bioorg Med Chem 2011 Jul 1;19(13):4028-42
GSK 163929	0	Piperidines Azabicyclo Compounds Receptors, CCR5/antagonists & inhibitors.	J Med Chem 2011 Jun 9;54(11):3756-67
2-(4-cyanophenyl)-N-(1-(1-(N,1-diphenylmethylsulfonamido)propan-2-yl)piperidin-4-yl)acetamide	0	Sulfonamides Benzeneacetamides Receptors, CCR5/agonists.	J Pharmacol Exp Ther 2011 Jun;337(3):655-62
N-(3-isopropyl-3-((4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)carbonyl)cyclopentyl)-3-methoxytetrahydro-2H-pyran-4-amine	0	Piperazines Pyrans Receptors, CCR5/antagonists & inhibitors Receptors, CCR2/antagonists & inhibitors.	Bioorg Med Chem Lett 2011 Mar 1;21(5):1442-6
N-(1-(3-(3,5-difluorophenyl)-3-(4-methanesulfonylphenyl)propyl)piperidin-4-yl)-N-ethyl-2-(4-methanesulfonylphenyl)acetamide	0	Sulfonamides Benzeneacetamides Receptors, CCR5/antagonists & inhibitors.	Arthritis Rheum 2010 Nov;62(11):3154-60
CCR5 receptor (222-240)	0	Peptide Fragments Receptors, CCR5.	J Pept Sci 2010 Apr;16(4):165-70
PF 232798	0	Imidazoles Azabicyclo Compounds Receptors, CCR5/antagonists & inhibitors.	TreatmentUpdate 2008 Mar;20(2):8
AD 101	0	Piperazines Niacinamide/analogs & derivatives Receptors, CCR5/antagonists & inhibitors.	Proc Natl Acad Sci U S A 2002 Jan 8;99(1):395-400
TAK-652	0	*Imidazoles Receptors, CCR5/antagonists & inhibitors Receptors, CCR2/antagonists & inhibitors.	Antimicrob Agents Chemother. 2005 Nov;49(11):4584-91
maraviroc	0	Cyclohexanes Triazoles Receptors, CCR5/antagonists & inhibitors HIV Fusion Inhibitors.	Drug Metab Dispos. 2005 Apr;33(4):587-95	SELZENTRY
UK 457,758	0	*Organic Chemicals Receptors, CCR5/antagonists & inhibitors.	Expert Opin Emerg Drugs 2004 May;9(1):1-7
RANTES, N(alpha)-(n-nonanoyl)-desSer(1)-(thioproline(2),cyclohexylglycine(3))	0	*Chemokine CCL5 Receptors, CCR5/antagonists & inhibitors.	Science 2004 Oct 15;306(5695):485-7
1-((4,6-dimethyl-5-pyrimidinyl)carbonyl)-4-(4-(2-methoxy-4-(trifluoromethyl)phenyl)ethyl-3-methyl-1-piperazinyl)-4-methylpiperidine	0	Piperazines Pyrimidines Receptors, CCR5/antagonists & inhibitors.	J Med Chem 2004 May 6;47(10):2405-8
(4,6-dimethyl-1-oxypyrimidin-5-yl)(4-diphenylamino-4'-methyl-(1,4')bipiperidinyl-1'-yl)methanone	0	Pyrimidinones Diphenylamine/analogs & derivatives Receptors, CCR5/antagonists & inhibitors.	J Med Chem 2004 Apr 8;47(8):1939-55
N-(3-(3-fluorophenyl)-4-((4-(3-benzyl-1-ethylpyrazol-5-yl)piperidin-1-yl)methyl)cyclopentyl)-N-methylvaline	0	Pyrazoles Valine/analogs & derivatives Receptors, CCR5/antagonists & inhibitors.	J Exp Med 2003 Nov 17;198(10):1551-62
4-((4-bromophenyl)-(ethoxyimino)methyl)-1'-((2,4-dimethyl-3-pyridinyl)carbonyl)-4'-methyl-1,4'-bipiperidine N-oxide	0	Cyclic N-Oxides Piperidines *Pyridines Receptors, CCR5/antagonists & inhibitors.	J Med Chem 2001 Oct 11;44(21):3339-42
PRO-140 monclonal antibody	0	HIV Antibodies Antibodies, Monoclonal, Humanized Anti-HIV Agents Receptors, CCR5 HIV Fusion Inhibitors.	Aids Patient Care STDS 2000 Dec;14(12):671; IDrugs. 2001 Sep;4(9):1068-71
TAK 779	229005-80-5	Amides Quaternary Ammonium Compounds Receptors, CCR5/antagonists & inhibitors HIV Fusion Inhibitors.	Proc Natl Acad Sci U S A 1999 May 11;96(10):5698-703

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

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