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Receptors, CXCR4

More information in Books or onNLM PubMed
Definition: CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.  DF: RECEPT CXCR4    Other names Receptor, CXCR4; Leukocyte Derived Seven Transmembrane Domain Recep; Receptor, LESTR; Leukocyte-Derived Seven-Transmembrane Domain Recep; LESTR Receptor; CXCR4 Receptor; Fusin; CXCR4 Receptors; CXC Chemokine Receptor 4
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AMD 11070  0   *Aminoquinolines *Benzimidazoles Receptors, CXCR4/antagonists & inhibitors. Mol Pharmacol 2008 Dec;74(6):1485-95
CXCR4a protein, zebrafish  0   *Receptors, CXCR4 *Zebrafish Proteins. Science 2008 Oct 3;322(5898):89-92
CXCR4 protein, human  0   *Receptors, CXCR4. J Immunol 1999 Sep 1;163(5):2368-72
N,N'-di-2-pyridinyl-1,4-benzenedimethanamine  0   *Aminopyridines *Benzylamines Receptors, CXCR4/antagonists & inhibitors. J Med Chem 2007 Nov 15;50(23):5655-64
1-pyridin-2-yl-N-(4-(1,4,7-triazacyclotetradecan-4-ylmethyl)benzyl)methanamine  0   *Pyridines Receptors, CXCR4/antagonists & inhibitors. FASEB J 2007 Oct;21(12):3219-30
cyclo(tyrosyl-methylarginyl-arginyl-3-(2-naphthyl)alanyl-glycyl)  0   *Peptides, Cyclic Receptors, CXCR4/antagonists & inhibitors. J Med Chem 2007 Jan 25;50(2):192-8
cyclo(tyrosyl-arginyl-arginyl-3-(2-naphthyl)alanyl-alanyl)  0   *Peptides, Cyclic Receptors, CXCR4/antagonists & inhibitors. J Med Chem 2007 Jan 25;50(2):192-8
POL2438 peptide  0   *Peptides, Cyclic Receptors, CXCR4/antagonists & inhibitors. Bioorg Med Chem 2006 Dec 15;14(24):8396-404
T22 peptide  0   *Peptides Receptors, CXCR4/antagonists & inhibitors. Mol Cancer Ther 2006 Oct;5(10):2592-9
5,5'-(1,4-phenylenebis(methylene))bis(1,5,8,12-tetraazabicyclo(10.2.2)hexadecane)  0   *Bicyclo Compounds, Heterocyclic Receptors, CXCR4/antagonists & inhibitors. J Med Chem 2006 Oct 19;49(21):6162-5
CXCR4 protein, mouse  0   *Receptors, CXCR4. J Biol Chem 2006 Sep 22;281(38):27765-72
N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylenebis(methylene))-2-(aminomethyl)- pyridine  0   *Pyridines Receptors, CXCR4/antagonists & inhibitors. Biochem Pharmacol 2005 Sep 1;70(5):752-61
cyclo(tyrosyl-arginyl-arginyl-3-(2-naphthyl)alanyl-glycyl)  0   *Peptides, Cyclic Receptors, CXCR4/antagonists & inhibitors. J Med Chem 2005 Jan 27;48(2):380-91
Cxcr4 protein, rat  0   *Receptors, CXCR4.
KRH 1636  0   *Pyridines Arginine/*analogs & derivatives Receptors, CXCR4/antagonists & inhibitors. Proc Natl Acad Sci U S A 2003 Apr 1;100(7):4185-90
odysseus protein, zebrafish  0   *Receptors, CXCR4 *Zebrafish Proteins. Nature 2003 Jan 16;421(6920):279-82
CGA 137053  0   *Amides *Imidazoles Receptors, CXCR4/antagonists & inhibitors. Chem Biol 2000 Sep;7(9):669-76
TW 70  0   *Peptides, Cyclic Receptors, CXCR4/antagonists & inhibitors. Bioorg Med Chem 1998 Feb;6(2):231-8
JM 3100  155148-31-5   *Heterocyclic Compounds Receptors, CXCR4/antagonists & inhibitors HIV Fusion Inhibitors.
Pharma Action Anti-HIV Agents 		Antimicrob Agents Chemother 1994 Apr;38(4):668-74MOZOBIL

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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