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Carbon-Carbon Ligases
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Definition
: Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.
DF: C C LIGASES
Examples
Acetyl-CoA Carboxylase
;
Polyketide Synthases
;
Pyruvate Carboxylase
Other names
Ligases, Carbon-
Carbon; Carbon Carbon Ligases
Substance
CAS Registry & name
Categories
Source
Drugs
*
3-
methylcrotonyl CoA carboxylase 2 deficiency
0
*Urea Cycle Disorders, Inborn
Carbon-Carbon Ligases/deficiency.
3-
methylcrotonyl CoA carboxylase 1 deficiency
0
*Urea Cycle Disorders, Inborn
Carbon-Carbon Ligases/deficiency.
naphthyl-
2-
methyl-
succinate synthase
EC 6.4.-
*Carbon-Carbon Ligases.
Appl Environ Microbiol 2000 Dec;66(12):5329-33
benzophenone synthase
EC 6.4.-
*Carbon-Carbon Ligases.
FEBS Lett 1996 Apr 1;383(3):264-6
3-
ketosphinganine synthetase
EC 6.4.-
*Carbon-Carbon Ligases.
J Biol Chem 251(6):1597;1976
propionyl CoA carboxylase (ATP-
hydrolyzing)
EC 6.4.1.3
*Carbon-Carbon Ligases.
Am J Hum Genet 1980;32(1):16; Am J Hum Genet 30(5):455;1978; Anal Biochem 52(1):305;1973; Biochem Genet 1979;17(7-8):703; Biochem Med 20(1):1;1978; Clin Chim Acta 100(2):183;1980; Clin Chim Acta 1980;101(2-3):217; Clin Chim Acta 76:321;1977; Clin Sci 1980;58(1):111; Enzyme 24(5):302;1979; J Biol Chem 252(23):8338;1977; J Biol Chem 254(13):5888;1979; J Biol Chem 255(1):236;1980; J Biol Chem 255(1):60;1980; J Clin Invest 64(6):1695;1979; J Inherit Metab Dis 1(1):3;1979; J Nutr 107(2):330;1977; Pediatr Res 9(7):559;1975; Pediatrics 1980;65(1):107; Postepy Biochem 25(2):141;1979
methylcrotonoyl-
CoA carboxylase
EC 6.4.1.4
*Carbon-Carbon Ligases.
Arch Biochem Biophys 1980;199(1):28; Biochem Biophys Res Commun 71(3):746;1976; Clin Chem Acta 1980;100(2):183; Clin Chim Acta 76:321;1977; Clin Chim Acta 84:399;1978; Clin Chimica Acta 73:513;1976; Clin Sci 1980;58(1):111; Enzyme 1979;24(5):302; Eur J Biochem 60:259;1975; J Clin Invest 64(6):1695;1979; Lancet 2(8134):118;1979; Lancet II (8095):901;1978; Pediatr Res 1979;13(11):1275; Pediatrics 49(5):726;1972; Proc Natl Acad Sci USA 76(1):214;1979
glutamyl carboxylase
EC 6.4.-
*Carbon-Carbon Ligases
Vitamin K.
Arch Biochem Biophys 191(2):571;1978; Biochem Biophys Res Commun 83(4):1488;1978; Biochem Biophys Res Commun 86(3):500;1979; Biochemistry 17(8):1371;1978; Biochim Biophys Acta 1980;627(3):225; Biochim Biophys Acta 499:181;1977; Calcif Tissue Int 1980;30(1):73; FEBS Lett 1980;109(2):267; J Biol Chem 1980;255(5):1808; J Biol Chem 251(9):2770;1976; J Biol Chem 254(4):1356;1979; Methods Enzymol 1980;67:165; Methods Enzymol 1980;67:180; Proc Natl Acad Sci USA 75(11):5413;1978; Proc Soc Exp Biol Med 161(4):498;1979; Recent Prog Blood Coag Thromb Res 44:55;1977
geranoyl-
CoA carboxylase
EC 6.4.1.5
*Carbon-Carbon Ligases.
Adv Enzymol 35(0):321;1971; Appl Environ Microbiol 1979; 38(4):715; Biochem Biophys Res Commun 71(3):746;1972
acyl-
CoA carboxylase
EC 6.4.1.-
*Carbon-Carbon Ligases.
Biochem Biophys Res Commun 82(3):834;1978; Biochemistry 17(10):1828;1978
