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Carbon-Oxygen Lyases

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Definition: Enzymes that catalyze the cleavage of a carbon-oxygen bond by means other than hydrolysis or oxidation. EC 4.2.  DF: C O LYASES   
Examples DNA-(Apurinic or Apyrimidinic Site) Lyase; Hydro-Lyases; Polysaccharide-Lyases
Other names Lyases, Carbon-Oxygen; Carbon Oxygen Lyases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tetraprenyl-beta-curcumene synthase, Bacillus megaterium  EC 4.2.-   *Carbon-Oxygen Lyases. J Am Chem Soc. 2011 Nov 9;133(44):17540-3.
MFE-2 protein, Drosophila  0   *Alcohol Oxidoreductases *Multienzyme Complexes *Carbon-Oxygen Lyases *Drosophila Proteins. Biochem J 2011 May 1;435(3):771-81
QueD protein, E coli  EC 4.2.-   *Carbon-Oxygen Lyases *Escherichia coli Proteins. Biochemistry 2009 Mar 24;48(11):2301-3
alpha-humulene synthase, Zingiber zerumbet  EC 4.2.-   *Carbon-Oxygen Lyases. Planta 2008 May;227(6):1291-9
phosphothreonine lyase, Salmonella enterica  EC 4.2.-   *Carbon-Oxygen Lyases. Nat Struct Mol Biol 2008 Jan;15(1):101-2
isochorismate pyruvate lyase, Nicotiana tabacum  EC 4.2.-   *Carbon-Oxygen Lyases. J Biotechnol 2007 Jan 30;128(1):72-9
fatty acid 9-, 13-hydroperoxide lyase, Oryza sativa  EC 4.2.-   *Cytochrome P-450 Enzyme System *Carbon-Oxygen Lyases. Biosci Biotechnol Biochem 2005 Aug;69(8):1545-54
O-phosphoserine sulfhydrylase, Aeropyrum pernix  EC 2.5.1.65   *Carbon-Oxygen Lyases. J Mol Biol 2005 Aug 12;351(2):334-44
geranyldiphosphate diphosphate lyase (pinene forming)  EC 4.2.3.14   *Carbon-Oxygen Lyases. Arch Biochem Biophys 2003 Mar 15;411(2):267-76
PsmI protein, Pseudomonas  EC 4.2.99.-   *Bacterial Proteins *Carbon-Oxygen Lyases. Appl Environ Microbiol 2001 Mar;67(3):1198-209
xanthan lyase  EC 4.2.2.12   *Carbon-Oxygen Lyases. Appl Environ Microbiol 1998 Oct;64(10):3765-68
serine sulfhydrolyase  EC 4.2.99.-   *Carbon-Oxygen Lyases. J Protozool 1985;32(1):32
triacetic acid lactone lyase  EC 4.2.99.-   *Carbon-Oxygen Lyases. Acta Biochim Biophys Acad Sci Hung 6(1):23;1971
threonine synthase  EC 4.2.99.2   *Carbon-Oxygen Lyases. J Biol Chem 248(3):1032;1973
O-succinylhomoserine (thiol)-lyase  EC 4.2.99.9   *Carbon-Oxygen Lyases. Biochemistry 18(9):1729;1979; J Bacteriol 133(3):1351;1978
methylglyoxal synthase  EC 4.2.99.11   *Carbon-Oxygen Lyases. Arch Biochem Biophys 183(1):1;1977; Biochem Biophys Res Commun 74(3):1007;1977; Biochem J 128(2):321;1972; J Am Chem Soc 99(13):4475;1977
ethanolaminephosphate phospho-lyase  EC 4.2.99.7 amino alcohol O-phosphate phospholyase (deaminating)  *Carbon-Oxygen Lyases. Arch Biochem Biophy 141(2):423;1970; Biochem J 134(4):959;1973; Scand J Clin Lab Invest 38(2):107;1978
carboxymethyloxysuccinic acid lyase  EC 4.2.99.12   *Carbon-Oxygen Lyases. Arch Biochem Biophys 162(1):135;1974
ADP-ribose-histone hydrolase  EC 4.2.99.-   *Carbon-Oxygen Lyases. Proc Natl Acad Sci USA 75(5):2554;1978
O-acetylhomoserine (thiol)-lyase  EC 2.5.1.47   *Carbon-Oxygen Lyases. FEBS Lett 101(1):97;1979; Genetics 71(4):542;1972; J Bacteriol 130(1):62;1977; J Biochem (Tokyo) 80:777;1976; J Biochem (Tokyo) 80:787;1976; J Biol Chem 245(7):1842;1970

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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