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Topotecan

More information in Books or onNLM PubMed
Definition: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.     
Pharmacological Action Topoisomerase I Inhibitors 		Other names SKF104864A; SKF 104864 A; SK&F104864A; SK&F 104864 A; NSC609699; NSC 609699; Hydrochloride, Topotecan; Hydrochloride, Nogitecan; 9 Dimethylaminomethyl 10 hydroxycamptothecin; Topotecan Monohydrochloride, (S)-Isomer; Topotecan Hydrochloride; SmithKline Beecham Brand of Topotecan Hydrochlorid; SKF-104864-A; SK&F-104864-A; Nogitecan Hydrochloride; NSC-609699; Hycamtin; Hycamtamine; 9-Dimethylaminomethyl-10-hydroxycamptothecinDrugs* : TOPOTECAN; TOPOTECAN HYDROCHLORIDE; HYCAMTIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TVTG protocol  0   *Antineoplastic Combined Chemotherapy Protocols Deoxycytidine/analogs & derivatives Dexamethasone Thiotepa Vinblastine/analogs & derivatives Topotecan. Haematologica 2005 Dec;90(12):1701-3
topotecan-20-O-(4-fluorophenoxyacetate)  0   Topotecan/*analogs & derivatives. Tao Xue Xue Bao 2004 Aug;39(8):591-7
CAT-G protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Topotecan. Bone Marrow Transplant 2002 Dec;30(12):975-8
TMC regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Melphalan Topotecan. Gynecol Oncol 2001 Sep;82(3):420-6
CPT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Topotecan Taxoids. Br J Cancer 2001 May 4;84(9):1166-71
TA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Topotecan. Ann N Y Acad Sci 2000;922:326-9
TAM protocol  0   Mitoxantrone *Antineoplastic Combined Chemotherapy Protocols Cytarabine Topotecan. Ann N Y Acad Sci 2000;922:326-9
CAT combination  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Cytarabine Topotecan. Ann N Y Acad Sci 2000;922:247-59
T 0128  0   *Dextrans Topotecan/*analogs & derivatives. Cancer Res 2000 Jun 1;60(11):2988-95
T 2153  0   Topotecan/*analogs & derivatives. Cancer Res 2000 Jun 1;60(11):2988-95
N-desmethyltopotecan  0   Topotecan/*analogs & derivatives. Cancer Chemother Pharmacol 1997;39(6):498-504

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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