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Simvastatin

More information in Books or onNLM PubMed
Definition: A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.     
Pharmacological Action Anticholesteremic Agents; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents 		Other names MK733; MK 733; Zocor; Synvinolin; MK-733Drugs* : ZOCOR; SIMVASTATIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Simcor  0   *Niacin *Simvastatin Drug Combinations Hypolipidemic Agents. Drugs R D. 2010;10(4):253-60SIMCOR
simvastatin hydroxyacid  0   Simvastatin/*analogs & derivatives. J Periodontol 2008 Aug;79(8):1457-64
simvaglyzin  0   *Glycyrrhizic Acid *Simvastatin. Biomed Khim. 2008 May-Jun;54(3):301-13
ezetimibe, simvastatin drug combination  0   *Azetidines *Simvastatin Drug Combinations. Med Lett Drugs Ther 2004 Sep 13;46(1191):73-4VYTORIN; EZETIMIBE; SIMVASTATIN
beta-hydroxy simvastatin acid  0   Simvastatin/*analogs & derivatives. Biopharm Drug Dispos. 2003 Jul;24(5):183-9
6-(2-(8-(2,2-dimethylbutyryl)oxy)-2,6-dimethyl-5-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one  0   Simvastatin/*analogs & derivatives. J Med Chem 1991;34(8):2489
simvastatin acid  121009-77-6 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta,8aalpha))  Simvastatin/*analogs & derivatives Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors. Exp Eye Res 1990;50(1):65

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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