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Genistein

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Definition: An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.     
Pharmacological Action Anticarcinogenic Agents; Phytoestrogens; Protein Kinase Inhibitors 		Other names Genestein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ITB 301  0   *Glycosides Genistein/*analogs & derivatives. Cancer Chemother Pharmacol 2011 Oct;68(4):1033-44
3',8-dichlorogenistein  0   Genistein/*analogs & derivatives. J Agric Food Chem. 2011 Jul 13;59(13):7506-13
8-chlorogenistein  0   Genistein/*analogs & derivatives. J Agric Food Chem. 2011 Jul 13;59(13):7506-13
genistein-4',7-diglucuronide  0   Genistein/*analogs & derivatives. Anal Bioanal Chem. 2010 Jun;397(4):1563-72
genistein-7-glucuronide-4'-sulfate  0   Genistein/*analogs & derivatives. Anal Bioanal Chem. 2010 Jun;397(4):1563-72
7-O-(2,3,4,6-tetra-O-acetylgalactopyranosyl)-1-4-(6-O-acetylhex-2-enepyranosyl)genistein  0   *Disaccharides Genistein/*analogs & derivatives. Bioorg Med Chem Lett 2009 Sep 1;19(17):4939-43
7-difluoromethyl-5,4'-dimethoxygenistein  0   Genistein/*analogs & derivatives. Eur J Pharmacol 2009 Mar 1;605(1-3):31-5
genistein 7,4'-(nitrooxy)butyrate  0   *Nitrates Genistein/*analogs & derivatives. J Pharmacol Sci 2007 May;104(1):82-9
genistein 7,4'-(bromo)butyrate  0   *Butyrates Genistein/*analogs & derivatives. J Pharmacol Sci 2007 May;104(1):82-9
genistein 4'7-O-dioleate  0   *Oleic Acids Genistein/*analogs & derivatives. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):115-20
8-(1,1-dimethylallyl)genistein  0   Genistein/*analogs & derivatives. Biol Pharm Bull. 2004 Apr;27(4):548-53
2'-hydroxy-genistein  0   Genistein/*analogs & derivatives. Drug Metab Dispos. 2003 Jul;31(7):924-31
3'-hydroxy-genistein  0   Genistein/*analogs & derivatives. Drug Metab Dispos. 2003 Jul;31(7):924-31
genistein-17.1A immunoconjugate  0   *Antibodies, Monoclonal *Immunoconjugates Genistein/*analogs & derivatives. Int J Oncol 2003 May;22(5):955-9
genistein combined polysaccharide  0   *Polysaccharides *Genistein. Mutat Res 2003 Feb-Mar;523-524:55-62
6-carboxymethyl genistein  0   Genistein/*analogs & derivatives. J Endocrinol 2002 Jun;173(3):415-27
EGF-genistein  0   *Epidermal Growth Factor *Genistein. Methods Mol Biol 2001;166:193-218
genistein-8-c-glucoside  0   *Glucosides Genistein/*analogs & derivatives. Biochemistry (Mosc) 2000 Aug;65(8):946-51
6,8-diprenylgenistein  0   Genistein/*analogs & derivatives. Biol Pharm Bull 1999 Oct;22(10):1144-6
biochanin A  491-80-5 5,7-dihydroxy-4'-methoxyisoflavone  *Genistein.
Pharma Action Anticarcinogenic Agents ; Phytoestrogens 		Res Vet Sci 22:216;1977; Science 191(4222):98;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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