Anti-Glomerular Basement Membrane Disease (definition)

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Anti-Glomerular Basement Membrane Disease

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Definition: An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.

See Also Glomerular Basement Membrane

Other names Syndrome, Goodpasture's; Syndrome, Goodpasture; Goodpastures Syndrome; Anti Glomerular Basement Membrane Disease; Anti GBM Disease; Lung Purpura with Nephritis; Goodpasture's Syndrome; Goodpasture Syndrome; Anti-GBM Disease

Substance	CAS Registry & name	Categories	Source
type IV collagen alpha3 chain	0	Autoantigens Collagen Type IV Epitopes Anti-Glomerular Basement Membrane Disease.	J Biol Chem 1988;263(26):13374

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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