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Kanamycin Kinase

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Definition: A class of enzymes that inactivate aminocyclitol-aminoglycoside antibiotics (AMINOGLYCOSIDES) by regiospecific PHOSPHORYLATION of the 3' and/or 5' hydroxyl.      Other names Transferase, Kanamycin-Neomycin Phosphate; Phosphotransferase, Neomycin; Phosphotransferase, Aminoglycoside; Phosphotransferase, Aminocyclitol; Phosphotransferase II, Neomycin; Phosphate Transferase, Kanamycin-Neomycin; Kanamycin Neomycin Phosphate Transferase; Aminoglycoside 3' Phosphotransferase Type VIII; Kinase, Kanamycin; Amikacin 3' Phosphotransferase; APT 3' I and II; 3'-Phosphotransferase, Amikacin; aphVII Gene Product; Neomycin Phosphotransferase II; Kanamycin-Neomycin Phosphate Transferase; Aminoglycoside Phosphotransferase Type III; Aminoglycoside 3'-Phosphotransferases (I and II); Aminoglycoside 3'-Phosphotransferase Type VIII; Aminocyclitol Phosphotransferase; Amikacin 3'-Phosphotransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AacA-AphD protein, methicillin-resistant Staphylococcus aureus  EC 2.7.1.-   *Bacterial Proteins *Kanamycin Kinase. Med Dosw Mikrobiol. 2010;62(4):289-95

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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