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Phosphatidylinositol 3-Kinases

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Definition: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.  note specifics including PHOSPHATIDYLINOSITOL 3-KINASE are available   
Examples Phosphatidylinositol 3-Kinase; Phosphatidylinositol-4-Phosphate 3-Kinase 		Other names PI-3K; PtdIns 3 Kinases; Phosphatidylinositol 3 Kinases; Kinases, PI3; 3-Kinases, PtdIns; PtdIns 3-Kinases; Phosphoinositide 3-Hydroxykinase; PI3-Kinase; PI3 Kinases; PI 3-Kinase; PtdIns 3-Kinase; Phosphatidylinositol-3-OH Kinase; PI-3 Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one  0   *Pyridones *Pyrimidines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Mol Cancer Ther. 2011 Nov;10(11):2189-99.
2,4-difluoro-N-(2-(methyloxy)-5-(4-(4-pyridazinyl)-6-quinolinyl)-3-pyridinyl)benzenesulfonamide  0   *Quinolines *Sulfonamides Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Cancer Biol Ther 2011 Jun 1;11(11):938-46
phosphoinositol-3 kinase regulatory subunit 2, human  EC 2.7.1.-   *Phosphatidylinositol 3-Kinases Protein Subunits. Mol Cell Biochem 2011 May;351(1-2):157-64
CAL 101  0   *Purines *Quinazolinones Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Blood 2010 Sep 2;116(9):1460-8
4-(2-(dimethylamino)vinyl)-2-(3-hydroxyphenyl)-6-morpholinopyrimidine-5-carbonitrile  0   *Morpholines *Pyrimidines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Sep 1;334(3):830-8
PKI 402  0   *Phenylurea Compounds *Pyrimidines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Mol Cancer Ther 2010 Apr;9(4):976-84
N-(2-(dimethylamino)ethyl)-N-methyl-4-(((4-(4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo(2,3-d)pyrimidin-2-yl)phenyl)carbamoyl)amino)benzamide  0   *Benzamides *Phenylurea Compounds Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2010 Apr 22;53(8):3169-82
PIK 75  0   *Hydrazones *Sulfonamides Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Am J Physiol Cell Physiol 2010 Apr;298(4):C929-41
LY 290042  0   *Chromones *Morpholines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Biochem Biophys Res Commun 2010 Apr 9;394(3):476-81
1-(4-((4-(Dimethylamino)piperidin-1-yl)carbonyl)phenyl)-3-(4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl)urea  0   *Morpholines *Triazines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2010 Mar 25;53(6):2636-45
Pik3cd protein, rat  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
Pik3cb protein, rat  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
Pik3cb protein, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
Pik3ca protein, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
Pik3c2g protein, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
Pik3c2g protein, rat  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
Pik3c2b protein, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
Pik3c2a protein, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
PIK3C2A protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
ETP 45658  0   *Pyrazoles *Pyrimidines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Biol Chem 2009 Oct 9;284(41):28392-400
PI 620  0   *Pyrimidines *Thiophenes Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Mol Cancer Ther 2009 Jul;8(7):1725-38
PI 540  0   *Pyrimidines *Thiophenes Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Mol Cancer Ther 2009 Jul;8(7):1725-38
3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol  0   *Phenols *Pteridines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Pharmacol Exp Ther 2009 Mar;328(3):758-65
N24 peptide, human  0   *Peptide Fragments *Phosphatidylinositol 3-Kinases. Mol Cancer Ther 2008 Dec;7(12):3719-28
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine  0   *Indazoles *Sulfonamides Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2008 Sep 25;51(18):5522-32
1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno(4,5-h)isochromene-5-yl acetate  0   *Benzopyrans *Indenes Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2008 Mar 13;51(5):1319-23
PIK3C2G protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Biochem Biophys Res Commun 2008 Jan 18;365(3):466-71
3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol  0   *Phenols *Pteridines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2007 Sep 6;50(18):4279-94
PIK3R3 protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases Protein Subunits. J Lipid Res 2007 Jul;48(7):1628-36
Pik3c2b protein, rat  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Adv Enzyme Regul. 2006;46():280-7
SMG1 protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Genes Dev 2001 Sep 1;15(17):2215-28
tor2 protein, S pombe  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases *Schizosaccharomyces pombe Proteins.
5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione  0   *Thiazolidinediones Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2006 Jun 29;49(13):3857-71
1-phosphatidylinositol 3-kinase p110 subunit, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. FASEB J 2006 Mar;20(3):455-65
pegylated 17-hydroxywortmannin  0   *Androstadienes *Polyethylene Glycols Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Med Chem 2006 Feb 23;49(4):1373-8
5-(2,2-difluorobenzo(1,3)dioxol-5-ylmethylene)thiazolidine-2,4-dione  0   *Dioxoles *Thiazolidinediones Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Nat Med 2005 Sep;11(9):936-43
5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione  0   *Quinoxalines *Thiazolidinediones Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Nat Med 2005 Sep;11(9):936-43
PIK3C2B protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Biochem Biophys Res Commun 1997 Apr 17;233(2):537-44
PIK3CB protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Circ Res 2004 Aug 20;95(4):380-8
PIKFYVE protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
IC 486068  0   *Quinazolines Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Cancer Res 2004 Jul 15;64(14):4893-9
p110delta protein, rat  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Hypertension 2004 Apr;43(4):885-90
PIK3CD protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases.
PIK3CA protein, human  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases Tumor Markers, Biological. Science 2004 Apr 23;304(5670):554
IC 87114  0   *Quinazolines Adenine/*analogs & derivatives Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Immunol 2003 Mar 1;170(5):2647-54
phosphatidyl-3-deoxy-3-aminoethyl-inositol  0   Inositol/*analogs & derivatives Phosphatidylinositol 3-Kinases. Bioorg Med Chem. 2001 Dec;9(12):3165-72
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol  0   *Inositol Phosphates Phosphatidylinositol 3-Kinases/antagonists & inhibitors. J Chromatogr A 2001 Apr 13;913(1-2):355-63
halenaquinone  86690-14-4   *Quinones Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Eur J Pharmacol 2001 Feb 9;413(1):37-45
Pik3cd protein, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Biochem Biophys Res Commun 2001 Feb 9;280(5):1328-32
KT 7692  0   *Androstadienes Myosin-Light-Chain Kinase/antagonists & inhibitors Phosphatidylinositol 3-Kinases. Life Sci 2000 Oct 13;67(21):2587-93
ATM protein, Arabidopsis  0   *Arabidopsis Proteins Phosphatidylinositol 3-Kinases. Nucleic Acids Res 2000 Apr 15;28(8):1692-9
Pi3K21B protein, Drosophila  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases *Drosophila Proteins. J Biol Chem 1997 Jun 6;272(23):14606-10
Pikfyve protein, mouse  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases. Mol Cell Biol 1999 Jan;19(1):623-34
PIK2 protein, Dictyostelium discoideum  EC 2.7.1.137   *Protozoan Proteins *Phosphatidylinositol 3-Kinases. J Cell Biol 1996 Mar 24;136(6):1271-86
PIK1 protein, Dictyostelium discoideum  EC 2.7.1.137   *Protozoan Proteins *Phosphatidylinositol 3-Kinases. J Cell Biol 1997 Mar 24;136(6):1271-86
AGE-1 protein, C elegans  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases *Caenorhabditis elegans Proteins. Nature 1996 Aug 8;382(6591):536-9
ataxia telangiectasia mutated protein  EC 2.7.11.1   *DNA-Binding Proteins *Protein-Serine-Threonine Kinases *Cell Cycle Proteins *Tumor Suppressor Proteins Ataxia Telangiectasia Leucine Zippers Phosphatidylinositol 3-Kinases. Hum Mol Genet 1996 Jan;5(1):145-9; Science 1995 Jun 23;268(5218):1749-53
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one  154447-36-6 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl  *Chromones *Morpholines Phosphatidylinositol 3-Kinases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Biol Chem 1994 Feb 18;269(7):5241-8
TOR1 protein, S cerevisiae  EC 2.7.1.137   *Phosphatidylinositol 3-Kinases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1993 Oct;13(10):6012-23
TOR2 protein, S cerevisiae  EC 2.7.1.137   *Cell Cycle Proteins *Phosphatidylinositol 3-Kinases *Saccharomyces cerevisiae Proteins. Cell 1993 May 7;73(3):585-96
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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