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Photoaffinity Labels

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Definition: Biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.      Other names Labels, Photoaffinity
Substances having this pharmacologic action: 3-(trifluoromethyl)-3-(3-iodophenyl)diazirine; 4-azidophenacyl bromide; 8-azidoadenosine-3',5'-monophosphate; benzoylphenylalanine; 4-nitrophenylgalactoside
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-azido-5-iodobenzyl fenpyroximate  0   *Azides *Benzoates Photoaffinity Labels. Biochemistry. 2012 Mar 6;51(9):1953-63.
4-azidophenyl fenpyroximate  0   *Azides *Benzoates Photoaffinity Labels. Biochemistry. 2012 Mar 6;51(9):1953-63.
4-(2-(diphenylmethoxy)ethyl)-1-benzyl piperidine  0   *Piperidines Photoaffinity Labels. Life Sci 2001 Mar 9;68(16):1839-49
N-(hydrocinchonidin-8'-yl)-4-azido-2-hydroxybenzamide  0   *Azides *Benzamides Photoaffinity Labels. Biochemistry 2000 May 23;39(20):6094-102
quinoylpropyl-trimethylammonium  0   *Quinones Photoaffinity Labels. Biochemistry 1999 Jun 8;38(23):7476-84
hydroquinoylpropyl-trimethylammonium  0   *Hydroquinones Photoaffinity Labels. Biochemistry 1999 Jun 8;38(23):7476-84
diazocyclohexadienoylpropyltrimethylammonium  0   *Diazonium Compounds Cholinergic Agents Photoaffinity Labels. Biochemistry 1999 Jun 8;38(23):7476-84
azidodantrolene  0   Dantrolene/*analogs & derivatives Ligands Tritium Photoaffinity Labels. J Med Chem 1999 Jun 3;42(11):1872-80
(trifluoromethyl)diazirinylpyridaben  0   *Azirines *Pyridazines Tritium Photoaffinity Labels. Proc Natl Acad Sci U S A 1999 Mar 30;96(7):4149-53
1-azidoanthracene  0   *Anthracenes *Azides Photoaffinity Labels. Chem Senses 1998 Dec;23(6):689-98
8-azidoadenosine 5'-triphosphate  53696-59-6 Adenosine 5'-(tetrahydrogen triphosphate), 8-azido  *Azides Adenosine Triphosphate/*analogs & derivatives Photoaffinity Labels.
Pharma Action Affinity Labels
Biochim Biophys Acta 1979;548(1):85; Eur J Biochem 88(1):253;1978; Eur J Biochem 93(1):141;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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