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Nitric Oxide Donors

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Definition: A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)     
See Also Nitric Oxide 		Other names Oxide Donors, Nitric; Donors, Nitric Oxide
Substances having this pharmacologic action: S-nitrosocysteine; isosorbide-5-mononitrate; S-nitrosomercaptoethanol; S-Nitrosothiols; S-Nitrosoglutathione; S-Nitroso-N-Acetylpenicillamine; 3-morpholino-sydnonimine; diethylenetriamine; Nitroprusside; Molsidomine; Isosorbide Dinitrate; S-nitro-N-acetylpenicillamine; naproxen-n-butyl nitrate; PAPA NONOate; 3-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-propanamine; spermine nitric oxide complex; NOC 18; 2,2'-(hydroxynitrosohydrazono)bis-ethanamine; GEA 3162; 1,1-diethyl-2-hydroxy-2-nitrosohydrazine; diethylamine dinitric oxide adduct; FK 409
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
O2-vinyl 1-(2-(carboxylato)pyrrolidin-1-yl)diazen-1-ium-1,2-diolate  0   *Pyrrolidines *Triazenes Nitric Oxide Donors. Chem Biol Interact 2011 Aug 15;193(1):88-96
3-(phenylsulfonyl)-4-(4-(1-(2-(3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoyl)pyrrolidine-2-carbonyloxy)but-2-ynyloxy)-1,2,5-oxadiazole-2-oxide  0   *Oxadiazoles Farnesol/*analogs & derivatives Nitric Oxide Donors. Biochem Biophys Res Commun 2011 Jun 17;409(4):752-7
NCX 434  0   *Nitrates Triamcinolone Acetonide/*analogs & derivatives Nitric Oxide Donors. J Ocul Pharmacol Ther 2011 Apr;27(2):115-21
3-(phenylsulfonyl)-4-(2-(4-(2-(3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoyl)piperazin-1-yl)ethoxy)-1,2,5-oxadiazole-2-oxide  0   *Oxadiazoles *Salicylic Acids Nitric Oxide Donors. J Med Chem 2011 May 12;54(9):3251-9
guaifenesin dinitrate  0   *Nitrates Guaifenesin/*analogs & derivatives Nitric Oxide Donors. Mol Pharm 2009 May-Jun;6(3):895-904
2-(dimethylamino)ethylputreanine-nitric oxide adduct  0   *Amino Acids, Diamino *Nitric Oxide Nitric Oxide Donors. J Appl Physiol 1997 Dec;83(6):1968-75
ethylputreanine-nitric oxide adduct  0   *Amino Acids, Diamino *Nitric Oxide Nitric Oxide Donors. J Appl Physiol 1997 Dec;83(6):1968-75
proline-nitric oxide  0   Proline/*analogs & derivatives Nitric Oxide Donors. J Med Chem 1996 Oct 25;39(22):4361-5

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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